A Novel Method for Fabricating Graphene Sensors in Channel for Biomedical Applications

2018 ◽  
Author(s):  
Prabhat Vashishth ◽  
Prosenjit Sen
Keyword(s):  
Biomedical Applications ◽  
Novel Method

Localized Microstructures Fabrication Through Standing Surface Acoustic Wave and User-Defined Waveguides

2019 ◽  
Author(s):  
Yancheng Wang ◽  
Chenyang Han ◽  
Deqing Mei ◽  
Chengyao Xu
Keyword(s):  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Structural Design ◽  
Acoustic Waves ◽  
Biomedical Applications ◽  
Cell Interaction ◽  
Experimental Setup ◽  
Acoustic Waveguides ◽  
Novel Method ◽  
Patterned Microstructure

Abstract Polymer-based substrates with patterned microstructure on the surfaces, e.g., cell culturing scaffolds, have been utilized in biomedical applications. This paper develops a novel method to fabricate the localized microstructure on the polymer-based substrate with the assistance of standing surface acoustic wave (SAW) and user-defined acoustic waveguides. The specific designed acoustic waveguides can localize the standing acoustic waves and transmit to the liquid film and excite patterned microstructures on the surface, then using ultraviolet (UV) to solidify the substrate with patterned microstructures. The structural design and fabrication of the SAW device and three different shaped acoustic waveguides are presented. Then, experimental setup and procedures to verify the polymer-substrate with localized microstructures fabrication are performed. By using the different shape of the acoustic waveguides, several types of patterned microstructures with different morphologies are successfully fabricated. Results demonstrated that the proposed fabrication method is an effective way to fabricate polymer-based substrate with localized patterned microstructures, which may have potential in the research on tissue engineering, cell-cell interaction, and other biomedical applications.

In Situ Growth of Carbon Nanotubes in Hydroxyapatite Matrix by Chemical Vapor Deposition

2009 ◽  
Vol 79-82 ◽  
pp. 1671-1674 ◽  
Author(s):  
Xiao Ying Lu ◽  
Hao Wang ◽  
Sheng Yi Xia ◽  
Jian Xin Wang ◽  
Jie Weng
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanotubes ◽  
Chemical Vapor Deposition ◽  
Vapor Deposition ◽  
Biomedical Applications ◽  
Chemical Vapor ◽  
Novel Method ◽  
Biomedical Fields ◽  
Walled Cnts

Carbon nanotubes (CNTs)/hydroxyapatite (HA) nanocomposites have been successfully fabricated by a novel method for the biomedical applications, which is in situ growing CNTs in HA matrix in a chemical vapor deposition (CVD) system. The results show that it is feasible to in situ grow CNTs in HA matrix by CVD for the fabrication of CNTs/HA nanocomposites. Multi-walled CNTs with 50-80 nm in diameter have been grown in situ from HA matrix with the pretreatment of sintering at 1473K in air. The nanocomposites are composed with carbon crystals in CNTs form, HA crystallites and calcium phosphate crystallites, one of most important CaP bioceramics. And the CNTs content is about 1% proportion by weight among the composites in our experiments, which can enhance the HA mechanical properties and the CNTs content does not affect the HA performances. These CNTs/HA nanocomposites have the potential application in the biomedical fields.

Fullerene Based Nanomaterials for Biomedical Applications: Engineering, Functionalization and Characterization

2013 ◽  
Vol 633 ◽  
pp. 224-238 ◽  
Author(s):  
Lidija Matija ◽  
Roumiana Tsenkova ◽  
Jelena Munćan ◽  
Mari Miyazaki ◽  
Kyoko Banba ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Biomedical Applications ◽  
Near Infrared ◽  
Biological Properties ◽  
Cage Structure ◽  
Carbon Cage ◽  
Novel Method ◽  
Medicine Analysis ◽  
New Skin

Since their discovery in 1985, fullerenes have attracted considerable attention. Their unique carbon cage structure provides numerous opportunities for functionalization, giving this nanomaterial great potential for applications in the field of medicine. Analysis of the chemical, physical, and biological properties of fullerenes and their derivatives showed promising results. In this study, functionalized fullerene based nanomaterials were characterized using near infrared spectroscopy, and a novel method - Aquaphotomics. These nanomaterials were then used for engineering a new skin cream formula for their application in cosmetics and medicine. In this paper, results of nanocream effects on the skin (using near infrared spectroscopy and aquaphotomics), and existing results of biocompatibility and cytotoxicity of fullerene base nanomaterials, are presented.

Polymer Based Micro Sensors Arrays for Ph and Glucose Monitoring

2010 ◽  
Vol 437 ◽  
pp. 354-358
Author(s):  
Olga Korostynska ◽  
Khalil Arshak ◽  
Arousian Arshak ◽  
Edric Gill ◽  
Padraig Creedon ◽  
...  
Keyword(s):  
Glucose Oxidase ◽  
Biomedical Applications ◽  
Point Of Care ◽  
Glucose Monitoring ◽  
Diagnostic System ◽  
Glucose Sensing ◽  
Electrical Characteristics ◽  
Dry Process ◽  
Sensors Array ◽  
Novel Method

Novel method of manufacturing micro sensors arrays for biomedical applications using BioForce NanoeNablerTM is reported. The operation of pH and glucose sensing elements is based on the properties of polymers, which exhibit a change in their electrical characteristics (such as resistance or capacitance) on exposure to solutions with different concentrations of pH or glucose. A sensor for glucose was successfully fabricated using the enzyme glucose oxidase immobilized within the polymer poly (o-phenylenediamine). This sensor was then successfully miniaturized utilizing immobilization for a dry process. The concentrations used for the microsensor were between 1 mM and 6 mM. Samples containing different concentrations of glucose were applied to the sensor while the system was being monitored for variances in either current or conductance. The resulting changes in the electrical characteristics of the sensor monitored in real time were found to be proportional to the different concentrations of glucose applied. Microscaled interdigitated electrodes were used for sensors array, with 48 sensors places on one chip. It is envisaged that findings of this work would form the basis for miniaturised point-of-care diagnostic system.

Fabrication of Polymeric Nano-Valve Array for Biomedical Applications

2010 ◽  
Author(s):  
Kuang-Fu Chang ◽  
Wen-Pin Shih ◽  
Chuin-Shan Chen
Keyword(s):  
Aluminum Oxide ◽  
Biomedical Applications ◽  
Anodic Aluminum Oxide ◽  
Sodium Ions ◽  
Constant Voltage ◽  
Small Power ◽  
Short Response Time ◽  
Anodic Aluminum ◽  
Close Time ◽  
Novel Method

Electro-active polymer working in aqueous medium has short response time and small power consumption. Polypyrrole is one of such electro-active polymers. Due to its stability, incorruptibility and micromachining compatibility, polypyrrole plays an important role in developing micro/nano-actuators for biological and chemical applications. This paper presents a flexible and reusable polypyrrole nano-valve array for biomedical applications. The nano-valves are formed by depositing polypyrrole on the anodic aluminum oxide (AAO) film by a novel method to ensure the integrity of the AAO film. The valves are actuated through the oxidation and reduction of the polypyrrole. The oxidation state of the polypyrrole makes sodium ions leaving the polypyrrole and hence contracts the polypyrrole. So the gold/polypyrrole bilayer was bended and the valves blocked. Conversely, the valve is opened as the reduction state. By controlling the open/close time with constant voltage, the diffusive quantity of the nano-valves can be easily changed.

scholarly journals Surface Engineered Iron Oxide Nanoparticles Generated by Inert Gas Condensation for Biomedical Applications

2021 ◽  
Vol 8 (3) ◽  
pp. 38
Author(s):  
Aver Hemben ◽  
Iva Chianella ◽  
Glenn John Thomas Leighton
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Physical Vapor Deposition ◽  
Biomedical Applications ◽  
Inert Gas ◽  
Oxide Nanoparticles ◽  
Free Standing ◽  
Gas Condensation ◽  
Inert Gas Condensation ◽  
Novel Method

Despite the lifesaving medical discoveries of the last century, there is still an urgent need to improve the curative rate and reduce mortality in many fatal diseases such as cancer. One of the main requirements is to find new ways to deliver therapeutics/drugs more efficiently and only to affected tissues/organs. An exciting new technology is nanomaterials which are being widely investigated as potential nanocarriers to achieve localized drug delivery that would improve therapy and reduce adverse drug side effects. Among all the nanocarriers, iron oxide nanoparticles (IONPs) are one of the most promising as, thanks to their paramagnetic/superparamagnetic properties, they can be easily modified with chemical and biological functions and can be visualized inside the body by magnetic resonance imaging (MRI), while delivering the targeted therapy. Therefore, iron oxide nanoparticles were produced here with a novel method and their properties for potential applications in both diagnostics and therapeutics were investigated. The novel method involves production of free standing IONPs by inert gas condensation via the Mantis NanoGen Trio physical vapor deposition system. The IONPs were first sputtered and deposited on plasma cleaned, polyethylene glycol (PEG) coated silicon wafers. Surface modification of the cleaned wafer with PEG enabled deposition of free-standing IONPs, as once produced, the soft-landed IONPs were suspended by dissolution of the PEG layer in water. Transmission electron microscopic (TEM) characterization revealed free standing, iron oxide nanoparticles with size < 20 nm within a polymer matrix. The nanoparticles were analyzed also by Atomic Force Microscope (AFM), Dynamic Light Scattering (DLS) and NanoSight Nanoparticle Tacking Analysis (NTA). Therefore, our work confirms that inert gas condensation by the Mantis NanoGen Trio physical vapor deposition sputtering at room temperature can be successfully used as a scalable, reproducible process to prepare free-standing IONPs. The PEG- IONPs produced in this work do not require further purification and thanks to their tunable narrow size distribution have potential to be a powerful tool for biomedical applications.

scholarly journals Decimation-Free Directional Filter Banks for Classification and Numbering on Posterior Dental Radiography Using Mesiodistal Neck Detection

2014 ◽  
Vol 18 (4) ◽  
pp. 649-657
Author(s):  
Agus Zainal Arifin ◽  
◽  
Anny Yuniarti ◽  
Wijayanti Nurul Khotimah ◽  
Arya Yudhi Wijaya ◽  
...  
Keyword(s):  
Support Vector Machine ◽  
Classification Accuracy ◽  
Biomedical Applications ◽  
Filter Bank ◽  
Dental Radiography ◽  
Support Vector ◽  
Segmentation Method ◽  
Accuracy Rate ◽  
Directional Filter ◽  
Novel Method

Dental classification and numbering on posterior dental radiography are important tasks for forensic and biomedical applications. This paper proposed a novel method of classification and numbering on posterior dental radiography using Decimation-Free Directional Filter Bank (DDFB) and mesiodistal neck detection. The method was started by a segmentation method for decomposing dental image into directional images using DDFB. Detection of mesiodistal neck tooth separated the crown and the root of teeth. Finally we used support vector machine for classification and numbering. The experimental results achieved a classification accuracy rate of 91%. It approved the robustness of the proposed method for solving the problem of dental classification and numbering.

scholarly journals Synthesis of Sub 3 nm-Sized Uniform Magnetite Nanoparticles Using Reverse Micelle Method for Biomedical Application

Materials ◽  
2019 ◽  
Vol 12 (23) ◽  
pp. 3850 ◽  
Author(s):  
Euiyoung Jung ◽  
Sung-Won Kim ◽  
Ahyoung Cho ◽  
Yu-Jin Kim ◽  
Gun-Jae Jeong ◽  
...  
Keyword(s):  
Magnetite Nanoparticles ◽  
Fe3o4 Nanoparticles ◽  
Reverse Micelles ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Experimental Conditions ◽  
Air Atmosphere ◽  
Size Uniformity ◽  
Novel Method ◽  
Apoptotic Activity

We report a synthetic method for small and uniform Fe3O4 (magnetite) nanoparticles under mild conditions. Spherical sub-3 nm-sized magnetite nanoparticles were prepared via reverse micelles composed of oleylamine, F127, xylene, and water for the reaction of iron(III) stearate with hydrazine at a reaction temperature of 90 °C in air atmosphere. These synthesized magnetite nanoparticles exhibited good size uniformity. By controlling experimental conditions, we could easily control both size and size uniformity of these magnetite nanoparticles. We further investigated whether Fe3O4 could be used in biomedical applications. Cytotoxicity of Fe3O4 was evaluated with human adipose-derived stem cells (hADSCs). Our results showed that the number of hADSCs did not significantly decrease when these cells were treated with Fe3O4 nanoparticles at a concentration of up to 9 μg/mL. Apoptotic activity and cell proliferation of hADSCs treated with Fe3O4 nanoparticles were similar to those of hADSCs without any treatment. This novel method could be used for synthesizing uniform and biocompatible Fe3O4 nanoparticles with further biomedical applications.

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