A semi-automated patient specific CFD analysis framework for cardiovascular system simulations

2011 ◽  
Author(s):  
E. Makris ◽  
P. Neofytou ◽  
S. Tsagaris ◽  
C. Housiadas
Keyword(s):  
Cardiovascular System ◽  
Patient Specific ◽  
Cfd Analysis ◽  
Analysis Framework

scholarly journals A Novel Patient-Specific Human Cardiovascular System Phantom (HCSP) for Reconstructions of Pulsatile Blood Hemodynamic Inside Abdominal Aortic Aneurysm

IEEE Access ◽  
2018 ◽  
Vol 6 ◽  
pp. 61896-61903 ◽  
Author(s):  
Andrzej Polanczyk ◽  
Michal Podgorski ◽  
Maciej Polanczyk ◽  
Aleksandra Piechota-Polanczyk ◽  
Christoph Neumayer ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Cardiovascular System ◽  
Patient Specific ◽  
Abdominal Aortic ◽  
Human Cardiovascular System

From Non-Invasive Hemodynamic Measurements towards Patient-Specific Cardiovascular Diagnosis

2012 ◽  
pp. 1-25
Author(s):  
Stefan Bernhard ◽  
Kristine Al Zoukra ◽  
Christof Schtte
Keyword(s):  
Inverse Problem ◽  
Bayesian Inference ◽  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Clinical Application ◽  
Patient Specific ◽  
The Novel ◽  
Physiological Models ◽  
Lack Of Information ◽  
Clinical Diagnoses

The past two decades have seen impressive success in medical technology, generating novel experimental data at an unexpected rate. However, current computational methods cannot sufficiently manage the data analysis for interpretation, so clinical application is hindered, and the benefit for the patient is still small. Even though numerous physiological models have been developed to describe complex dynamical mechanisms, their clinical application is limited, because parameterization is crucial, and most problems are ill-posed and do not have unique solutions. However, this information deficit is imminent to physiological data, because the measurement process always contains contamination like artifacts or noise and is limited by a finite measurement precision. The lack of information in hemodynamic data measured at the outlet of the left ventricle, for example, induces an infinite number of solutions to the hemodynamic inverse problem (possible vascular morphologies that can represent the hemodynamic conditions) (Quick, 2001). Within this work, we propose that, despite these problems, the assimilation of morphological constraints, and the usage of statistical prior knowledge from clinical observations, reveals diagnostically useful information. If the morphology of the vascular network, for example, is constrained by a set of time series measurements taken at specific places of the cardiovascular system, it is possible to solve the hemodynamic inverse problem by a carefully designed mathematical forward model in combination with a Bayesian inference technique. The proposed cardiovascular system identification procedure allows us to deduce patient-specific information that can be used to diagnose a variety of cardiovascular diseases in an early state. In contrast to traditional inversion approaches, the novel method produces a distribution of physiologically interpretable models (patient-specific parameters and model states) that allow the identification of disease specific patterns that correspond to clinical diagnoses, enabling a probabilistic assessment of human health condition on the basis of a broad patient population. In the ongoing work we use this technique to identify arterial stenosis and aneurisms from anomalous patterns in signal and parameter space. The novel data mining procedure provides useful clinical information about the location of vascular defects like aneurisms and stenosis. We conclude that the Bayesian inference approach is able to solve the cardiovascular inverse problem and to interpret clinical data to allow a patient-specific model-based diagnosis of cardiovascular diseases. We think that the information-based approach provides a useful link between mathematical physiology and clinical diagnoses and that it will become constituent in the medical decision process in near future.

From Non-Invasive Hemodynamic Measurements towards Patient-Specific Cardiovascular Diagnosis

Data Mining ◽  
2013 ◽  
pp. 2069-2093
Author(s):  
Stefan Bernhard ◽  
Kristine Al Zoukra ◽  
Christof Schtte
Keyword(s):  
Inverse Problem ◽  
Bayesian Inference ◽  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Clinical Application ◽  
Patient Specific ◽  
The Novel ◽  
Physiological Models ◽  
Lack Of Information ◽  
Clinical Diagnoses

The past two decades have seen impressive success in medical technology, generating novel experimental data at an unexpected rate. However, current computational methods cannot sufficiently manage the data analysis for interpretation, so clinical application is hindered, and the benefit for the patient is still small. Even though numerous physiological models have been developed to describe complex dynamical mechanisms, their clinical application is limited, because parameterization is crucial, and most problems are ill-posed and do not have unique solutions. However, this information deficit is imminent to physiological data, because the measurement process always contains contamination like artifacts or noise and is limited by a finite measurement precision. The lack of information in hemodynamic data measured at the outlet of the left ventricle, for example, induces an infinite number of solutions to the hemodynamic inverse problem (possible vascular morphologies that can represent the hemodynamic conditions) (Quick, 2001). Within this work, we propose that, despite these problems, the assimilation of morphological constraints, and the usage of statistical prior knowledge from clinical observations, reveals diagnostically useful information. If the morphology of the vascular network, for example, is constrained by a set of time series measurements taken at specific places of the cardiovascular system, it is possible to solve the hemodynamic inverse problem by a carefully designed mathematical forward model in combination with a Bayesian inference technique. The proposed cardiovascular system identification procedure allows us to deduce patient-specific information that can be used to diagnose a variety of cardiovascular diseases in an early state. In contrast to traditional inversion approaches, the novel method produces a distribution of physiologically interpretable models (patient-specific parameters and model states) that allow the identification of disease specific patterns that correspond to clinical diagnoses, enabling a probabilistic assessment of human health condition on the basis of a broad patient population. In the ongoing work we use this technique to identify arterial stenosis and aneurisms from anomalous patterns in signal and parameter space. The novel data mining procedure provides useful clinical information about the location of vascular defects like aneurisms and stenosis. We conclude that the Bayesian inference approach is able to solve the cardiovascular inverse problem and to interpret clinical data to allow a patient-specific model-based diagnosis of cardiovascular diseases. We think that the information-based approach provides a useful link between mathematical physiology and clinical diagnoses and that it will become constituent in the medical decision process in near future.

Abstract P304: A Novel Method for Modeling Flow in Cerebral Vasculature Diagnostics

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Huy Dinh
Keyword(s):  
Cfd Simulation ◽  
Fluid Dynamic ◽  
Physiological Saline ◽  
Patient Specific ◽  
Cfd Analysis ◽  
Velocity Data ◽  
Flow Measurements ◽  
Flow Parameters ◽  
Flow Pressure ◽  
Dependent Flow

Introduction: We examined the viability of pairing wire-obtained flow pressure data with computational fluid dynamic (CFD) analysis for accurate patient-specific 3D reconstruction of flow through cerebral vessels—an approach that provides comprehensive velocity data and other flow parameters to assist the preventative diagnosis of cerebral stenosis. Methods: Two physical phantom models of a cerebral stenosis—differing in regard to vascular morphology at and around the stenosis—were prepared, filled with physiological saline and connected individually to a flow pump (Vascular Simulations LLC Left Heart Replicator) applying pulsatile flow. Pressure measurements were taken upstream of the stenosis by microcatheter-guided wires to define an inlet boundary condition for CFD analysis. Pressure and velocity at 2 cm proximal to stenosis, the stenosis inlet, the stenosis outlet, and 2 cm distal to stenosis were measured to validate the CFD simulated flow. Results: Excellent agreement was observed between CFD and wire-measured time-dependent flow pressure, with the expected pulsatile behavior observed at each location. Between the two methods, differences in maximum systolic pressures ranged between |0.73±0.72|% and |3.90±0.74|%. Differences in minimum diastolic pressures ranged between |1.79±1.33|% and |9.08±1.42|%. Velocity data from wire measurements lacked pulsatile behavior and showed differences ranging between |2.93±5.20|% and |120.10±2.91|% from CFD-obtained measurements, which did show correct pulsatile behavior. Larger discrepancies were strongly associated with areas of higher CFD predicted velocities (r=0.86). Conclusion: Guidewire flow measurements provided CFD analysis with accurate inlet boundary conditions and validated CFD simulation results. CFD analysis allowed for detailed visualization of key flow parameters that may be difficult to physically measure—such as velocity—that are relevant for understanding risk factors associated with cerebral stenosis on a case-by-case basis.

Development of a Numerical Method for Patient-Specific Cerebral Circulation Using 1D–0D Simulation of the Entire Cardiovascular System with SPECT Data

2015 ◽  
Vol 44 (8) ◽  
pp. 2351-2363 ◽  
Author(s):  
Hao Zhang ◽  
Naoya Fujiwara ◽  
Masaharu Kobayashi ◽  
Shigeki Yamada ◽  
Fuyou Liang ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Numerical Method ◽  
Cerebral Circulation ◽  
Patient Specific

CFD Analysis of a Human Lung

2010 ◽  
Author(s):  
S. Taherian ◽  
H. R. Rahai ◽  
Tom Waddington
Keyword(s):  
Particle Deposition ◽  
Human Lung ◽  
Patient Specific ◽  
Cfd Analysis ◽  
Image Transfer ◽  
Respiratory Problems ◽  
Numerical Investigations ◽  
Airway Diseases ◽  
Treatment Procedures ◽  
Central Airway

Understanding the characteristic of airflow, and the amount of particle deposition in different sections of respiratory system provides information for treatment procedures and processes. Results of preliminary numerical investigations for development of a system of image transfer and simulation to identify patient specific respiratory problem are presented. The system is a non-intrusive approach for evaluation of central airway diseases which could also be used for development of methods for reviving and recovery of damaged lung, especially at the onset of respiratory problems.

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