Computational flow dynamics in patient specific model of cardiovascular system using CT and MRI

Author(s):  
S. Yamamoto ◽  
H. Bartsch ◽  
S. Maruyama ◽  
S. Yoneyama ◽  
S. Wada ◽  
...  
2019 ◽  
Author(s):  
Francesca Donadoni ◽  
Cesar Pichardo-Almarza ◽  
Shervanthi Homer-Vanniasinkam ◽  
Alan Dardik ◽  
Vanessa Díaz-Zuccarini

AbstractBypass occlusion due to neointimal hyperplasia (NIH) is among the major causes of peripheral graft failure. Its link to abnormal hemodynamics in the graft is complex, and isolated use of hemodynamic markers insufficient to fully capture its progression. Here, a computational model of NIH growth is presented, establishing a link between computational fluid dynamics (CFD) simulations of flow in the lumen, with a biochemical model representing NIH growth mechanisms inside the vessel wall. For all 3 patients analyzed, NIH at proximal and distal anastomoses was simulated by the model, with values of stenosis comparable to the computed tomography (CT) scans.


2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Gaoyang Li ◽  
Haoran Wang ◽  
Mingzi Zhang ◽  
Simon Tupin ◽  
Aike Qiao ◽  
...  

AbstractThe clinical treatment planning of coronary heart disease requires hemodynamic parameters to provide proper guidance. Computational fluid dynamics (CFD) is gradually used in the simulation of cardiovascular hemodynamics. However, for the patient-specific model, the complex operation and high computational cost of CFD hinder its clinical application. To deal with these problems, we develop cardiovascular hemodynamic point datasets and a dual sampling channel deep learning network, which can analyze and reproduce the relationship between the cardiovascular geometry and internal hemodynamics. The statistical analysis shows that the hemodynamic prediction results of deep learning are in agreement with the conventional CFD method, but the calculation time is reduced 600-fold. In terms of over 2 million nodes, prediction accuracy of around 90%, computational efficiency to predict cardiovascular hemodynamics within 1 second, and universality for evaluating complex arterial system, our deep learning method can meet the needs of most situations.


2021 ◽  
Vol 14 (3) ◽  
pp. e239192
Author(s):  
Jayanthi Parthasarathy ◽  
Eric A Sribnick ◽  
Mai-Lan Ho ◽  
Allan Beebe

3D-printed patient-specific models provide added value for initial clinical diagnosis, preoperative surgical and implant planning and patient and trainee education. 3D spine models are usually designed using CT data, due to the ability to rapidly image osseous structures with high spatial resolution. Combining CT and MRI to derive a composite model of bony and neurological anatomy can potentially provide even more useful information for complex cases. We describe such a case involving an adolescent with a grade V spondylolisthesis in which a composite model was manufactured for preoperative and intraoperative evaluation and guidance. We provide a detailed workflow for creating such models and outline their potential benefit in guiding a multidisciplinary team approach.


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