Simulated annealing search through general structure floorplans using sequence-pair

2002 ◽  
Author(s):  
K. Kiyota ◽  
K. Fujiyoshi
Keyword(s):  
Simulated Annealing ◽  
General Structure ◽  
Sequence Pair

Cloning of the Rat Tissue Factor cDNA and Promoter: Identification of a Serum-response Region

1996 ◽  
Vol 76 (05) ◽  
pp. 697-702 ◽  
Author(s):  
Olivier Taby ◽  
Claire-Lise Rosenfield ◽  
Vladimir Bogdanov ◽  
Yale Nemerson ◽  
Mark B Taubman
Keyword(s):  
Tissue Factor ◽  
General Structure ◽  
Amino Acid Sequences ◽  
Proximal Promoter ◽  
Striking Similarity ◽  
Upstream Sequence ◽  
Tf Gene ◽  
Rat Tissue ◽  
High Degree ◽  
Transcriptional Elements

SummaryTissue factor (TF) initiates coagulation and its expression in vascular smooth muscle cells (VSMC) likely plays a role in the propagation of arterial thrombosis. We report cloning the cDNA and proximal promoter region of the rat TF gene. While maintaining the general structure and organization of the TF molecule, there is a surprising divergence (≈ 18%) between the derived amino acid sequences of the rat and mouse TF. In contrast, there is striking similarity (90%) in the 5’ untranslated regions. High levels of basal promoter activity were seen in rat VSMC with constructs containing 106 bp of sequence downstream from the putative transcription start site and 426 to 103 bp of upstream sequence. Deletion of the sequence from −103 to −79, containing a single SP1 site, removed virtually all of the basal and serum-induced activity. Removal of the NFkB site or two additional upstream SP1 sites had little effect on serum responsiveness. Removal of the 5’ untranslated region abolished most of the basal activity of the TF promoter, suggesting that its high degree of conservation may be due to the presence of transcriptional elements critical for TF expression in rodent VSMC.

Penjadwalan Produksi Menggunakan Metode Simulated Annealing pada Unit Produksi Daun Pintu di PT. ML

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Rosnani Ginting ◽  
Chairul Rahmadsyah Manik
Keyword(s):  
Simulated Annealing ◽  
Problem Solving ◽  
Production Scheduling ◽  
Production Control ◽  
Delivery Time ◽  
Production Schedule ◽  
A Company ◽  
Predetermined Time ◽  
Factory Floor

Penjadwalan merupakan aspek yang sangat penting karena didalamnya terdapat elemen perencanaan dan pengendalian produksi bagi suatu perusahaan yang dapat mengirim barang sesuai dengan waktu yang telah ditentukan, untuk memperoleh waktu total penyelesaian yang minimum. Masalah utama yang dihadapi oleh PT. ML adalah keterlambatan penyelesaian order yang mempengaruhi delivery time ke tangan costumer karena pelaksanaan penjadwalan produksi dilantai pabrik belum menghasilkan makespan yang sesuai dengan order yang ada. Oleh kaena itu dituntut untuk mencari solusi pemecahan masalah optimal dalam penentuan jadwal produksi untuk meminimisasi total waktu penyelessaian (makespan) semua order. Dalam penelitian ini, penjadwalan menggunakan metode Simulated Annealing (SA) diharapkan dapat menghasilkan waktu total penyelesaian lebih cepat dari penjadwalan yang ada pada perusahaan.   Scheduling is a very important aspect because in it there are elements of planning and production control for a company that can send goods in accordance with a predetermined time, to obtain a minimum total time of completion. The main problem faced by PT. ML is the delay in completing orders that affect delivery time to customer because the implementation of production scheduling on the factory floor has not produced the makespan that matches the existing order. Therefore, it is required to find optimal problem solving solutions in determining the production schedule to minimize the total time of elimination (makespan) of all orders. In this study, scheduling using the Simulated Annealing (SA) method is expected to produce a total time of completion faster than the existing scheduling in the company.

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