A closed loop PRF stimulation system for sympathetic nerve with an implantable micro-stimulator

2015 ◽  
Author(s):  
Mu-Lien Lin ◽  
Chin-Hong Guo ◽  
Xin-Zhu Lin ◽  
Zih-Rong Huang ◽  
Shen-Chieh Lin ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Closed Loop ◽  
Stimulation System

scholarly journals Effect of Closed-Loop Vibration Stimulation on Heart Rhythm during Naps

Sensors ◽  
2019 ◽  
Vol 19 (19) ◽  
pp. 4136 ◽  
Author(s):  
Sang Ho Choi ◽  
Heenam Yoon ◽  
Hyung Won Jin ◽  
Hyun Bin Kwon ◽  
Seong Min Oh ◽  
...  
Keyword(s):  
High Frequency ◽  
Closed Loop ◽  
Low Frequency ◽  
Heart Rhythm ◽  
Quality Of Sleep ◽  
Stimulation Condition ◽  
Term Basis ◽  
Stimulation System

Sleep plays a primary function for health and sustains physical and cognitive performance. Although various stimulation systems for enhancing sleep have been developed, they are difficult to use on a long-term basis. This paper proposes a novel stimulation system and confirms its feasibility for sleep. Specifically, in this study, a closed-loop vibration stimulation system that detects the heart rate (HR) and applies −n% stimulus beats per minute (BPM) computed on the basis of the previous 5 min of HR data was developed. Ten subjects participated in the evaluation experiment, in which they took a nap for approximately 90 min. The experiment comprised one baseline and three stimulation conditions. HR variability analysis showed that the normalized low frequency (LF) and LF/high frequency (HF) parameters significantly decreased compared to the baseline condition, while the normalized HF parameter significantly increased under the −3% stimulation condition. In addition, the HR density around the stimulus BPM significantly increased under the −3% stimulation condition. The results confirm that the proposed stimulation system could influence heart rhythm and stabilize the autonomic nervous system. This study thus provides a new stimulation approach to enhance the quality of sleep and has the potential for enhancing health levels through sleep manipulation.

Effective Relief of Pain and Associated Symptoms With Closed-Loop Spinal Cord Stimulation System: Preliminary Results of the Avalon Study

2017 ◽  
Vol 21 (1) ◽  
pp. 38-47 ◽  
Author(s):  
Marc Russo ◽  
Michael J. Cousins ◽  
Charles Brooker ◽  
Nathan Taylor ◽  
Tillman Boesel ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
Closed Loop ◽  
Preliminary Results ◽  
Associated Symptoms ◽  
Stimulation System

scholarly journals Erratum: Conceptualization and validation of an open-source closed-loop deep brain stimulation system in rat

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Hemmings Wu ◽  
Hartwin Ghekiere ◽  
Dorien Beeckmans ◽  
Tim Tambuyzer ◽  
Kris van Kuyck ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Open Source ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Stimulation System ◽  
Deep Brain

Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity

2006 ◽  
Vol 291 (1) ◽  
pp. H318-H326 ◽  
Author(s):  
Daisaku Michikami ◽  
Atsunori Kamiya ◽  
Toru Kawada ◽  
Masashi Inagaki ◽  
Toshiaki Shishido ◽  
...  
Keyword(s):  
Pulse Duration ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Closed Loop ◽  
Equilibrium Diagram ◽  
Threshold Current ◽  
Operating Point ◽  
Arterial Baroreflex ◽  
Short Term ◽  
Nerve Activity

Although electroacupuncture reduces sympathetic nerve activity (SNA) and arterial pressure (AP), the effects of electroacupuncture on the arterial baroreflex remain to be systematically analyzed. We investigated the effects of electroacupuncture of Zusanli on the arterial baroreflex using an equilibrium diagram comprised of neural and peripheral arcs. In anesthetized, vagotomized, and aortic-denervated rabbits, we isolated carotid sinuses and changed intra-carotid sinus pressure (CSP) from 40 to 160 mmHg in increments of 20 mmHg/min while recording cardiac SNA and AP. Electroacupuncture of Zusanli was applied with a pulse duration of 5 ms and a frequency of 1 Hz. An electric current 10 times the minimal threshold current required for visible muscle twitches was used and was determined to be 4.8 ± 0.3 mA. Electroacupuncture for 8 min decreased SNA and AP ( n = 6). It shifted the neural arc (i.e., CSP-SNA relationship) to lower SNA but did not affect the peripheral arc (i.e., SNA-AP relationship) ( n = 8). SNA and AP at the closed-loop operating point, determined by the intersection of the neural and peripheral arcs, decreased from 100 ± 4 to 80 ± 9 arbitrary units and from 108 ± 9 to 99 ± 8 mmHg (each P < 0.005), respectively. Peroneal denervation eliminated the shift of neural arc by electroacupuncture ( n = 6). Decreasing the pulse duration to <2.5 ms eliminated the effects of SNA and AP reduction. In conclusion, short-term electroacupuncture resets the neural arc to lower SNA, which moves the operating point toward lower AP and SNA under baroreflex closed-loop conditions.

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