scholarly journals Erratum: Conceptualization and validation of an open-source closed-loop deep brain stimulation system in rat

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Hemmings Wu ◽  
Hartwin Ghekiere ◽  
Dorien Beeckmans ◽  
Tim Tambuyzer ◽  
Kris van Kuyck ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Open Source ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Stimulation System ◽  
Deep Brain

scholarly journals Conceptualization and validation of an open-source closed-loop deep brain stimulation system in rat

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Hemmings Wu ◽  
Hartwin Ghekiere ◽  
Dorien Beeckmans ◽  
Tim Tambuyzer ◽  
Kris van Kuyck ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Deep Brain Stimulation ◽  
Open Source ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Symptom Control ◽  
Theta Oscillations ◽  
Open Source Hardware ◽  
Hippocampal Theta ◽  
Deep Brain

Abstract Conventional deep brain stimulation (DBS) applies constant electrical stimulation to specific brain regions to treat neurological disorders. Closed-loop DBS with real-time feedback is gaining attention in recent years, after proved more effective than conventional DBS in terms of pathological symptom control clinically. Here we demonstrate the conceptualization and validation of a closed-loop DBS system using open-source hardware. We used hippocampal theta oscillations as system input and electrical stimulation in the mesencephalic reticular formation (mRt) as controller output. It is well documented that hippocampal theta oscillations are highly related to locomotion, while electrical stimulation in the mRt induces freezing. We used an Arduino open-source microcontroller between input and output sources. This allowed us to use hippocampal local field potentials (LFPs) to steer electrical stimulation in the mRt. Our results showed that closed-loop DBS significantly suppressed locomotion compared to no stimulation and required on average only 56% of the stimulation used in open-loop DBS to reach similar effects. The main advantages of open-source hardware include wide selection and availability, high customizability and affordability. Our open-source closed-loop DBS system is effective and warrants further research using open-source hardware for closed-loop neuromodulation.

scholarly journals Algorithmic design of a noise-resistant and efficient closed-loop deep brain stimulation system: A computational approach

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0171458 ◽  
Author(s):  
Sofia D. Karamintziou ◽  
Ana Luísa Custódio ◽  
Brigitte Piallat ◽  
Mircea Polosan ◽  
Stéphan Chabardès ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Computational Approach ◽  
System A ◽  
Algorithmic Design ◽  
Stimulation System ◽  
Deep Brain

Closed-loop wearable ultrasound deep brain stimulation system based on EEG in mice

2021 ◽  
Author(s):  
Yongsheng Zhong ◽  
YiBo Wang ◽  
Zhuoyi He ◽  
Zhengrong Lin ◽  
Na Pang ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Stimulation System ◽  
Deep Brain

Closed-loop programming using external responses for deep brain stimulation in Parkinson's disease

2021 ◽  
Vol 84 ◽  
pp. 47-51
Author(s):  
Fuyuko Sasaki ◽  
Genko Oyama ◽  
Satoko Sekimoto ◽  
Maierdanjiang Nuermaimaiti ◽  
Hirokazu Iwamuro ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Deep Brain
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