A probabilistic analysis method for functional qualification under Mutation Analysis

2012 ◽  
Author(s):  
Hsiu-Yi Lin ◽  
Chun-Yao Wang ◽  
Shih-Chieh Chang ◽  
Yung-Chih Chen ◽  
Hsuan-Ming Chou ◽  
...  
Keyword(s):  
Mutation Analysis ◽  
Probabilistic Analysis ◽  
Analysis Method

scholarly journals Design and Generation of MLPA Probe Sets for Combined Copy Number and Small-Mutation Analysis of Human Genes: EGFR as an Example

2010 ◽  
Vol 10 ◽  
pp. 2003-2018 ◽  
Author(s):  
Malgorzata Marcinkowska ◽  
Kwok-Kin Wong ◽  
David J. Kwiatkowski ◽  
Piotr Kozlowski
Keyword(s):  
Mutation Analysis ◽  
Copy Number ◽  
Analysis Method ◽  
Copy Number Analysis ◽  
Short Oligonucleotide ◽  
Human Genes ◽  
Simple Protocol ◽  
Commercial Kits ◽  
Genomic Regions ◽  
Dependent Probe

Multiplex ligation-dependent probe amplification (MLPA) is a multiplex copy number analysis method that is routinely used to identify large mutations in many clinical and research labs. One of the most important drawbacks of the standard MLPA setup is a complicated, and therefore expensive, procedure of generating long MLPA probes. This drawback substantially limits the applicability of MLPA to those genomic regions for which ready-to-use commercial kits are available. Here we present a simple protocol for designing MLPA probe sets that are composed entirely of short oligonucleotide half-probes generated through chemical synthesis. As an example, we present the design and generation of an MLPA assay for parallel copy number and small-mutation analysis of theEGFRgene.

Probabilistic Analysis of Local Ice Pressures

1993 ◽  
Vol 115 (1) ◽  
pp. 83-89 ◽  
Author(s):  
I. J. Jordaan ◽  
M. A. Maes ◽  
P. W. Brown ◽  
I. P. Hermans
Keyword(s):  
Contact Area ◽  
Probabilistic Analysis ◽  
Exceedance Probability ◽  
Analysis Method ◽  
Expected Number ◽  
Ice Loads ◽  
Probability Plots ◽  
Nominal Contact Area ◽  
Exposure Length

Extensive work in recent years has been carried out on the calculation of global ice loads on a probabilistic basis. An analysis method is presented for local ice pressures, which yields values of pressure for specific values of exceedance probability. In developing this method, particular attention has been paid to problems of exposure (length, position and number of impacts), as well as the area of exposure (area within area versus nominal contact area). The solution has been formulated for a series of discrete impacts, e.g., rams by a vessel, or a series of periods of continuous interactions. Data for the MV CANMAR Kigoriak and USCGC Polar Sea were ranked and curves were fitted through the tail of probability plots for three panel sizes. This allowed determination of exceedance probabilities of the design coefficients for pressure as a function of area. The method developed was then applied to an example for a ship based on the data and expected number of rams per year. Formulas useful in the design of structures in ice are presented.

DIELECTRON PRODUCTION IN C+C AT 1 AGeV WITH HADES

2007 ◽  
Vol 22 (02n03) ◽  
pp. 600-603 ◽  
Author(s):  
◽  
TASSILO CHRIST
Keyword(s):  
Cross Sections ◽  
Probabilistic Analysis ◽  
Beam Energy ◽  
Mass Spectra ◽  
Production Cross ◽  
Analysis Method ◽  
Invariant Pair

The production of e+e- - pairs has been measured for C + C collisions at a beam energy of 1 AGeV. Preliminary invariant pair mass spectra are constructed utilizing a probabilistic analysis method for the identification of single e+/e- tracks. The results are compared to predictions based on sources with known production cross sections, and to earlier measurements.

Probabilistic Fracture Analysis of Functionally Graded Materials—Part I: Uncertainty and Probabilistic Analysis Method

2008 ◽  
Author(s):  
Junho Song ◽  
Tam H. Nguyen ◽  
Glaucio H. Paulino ◽  
Glaucio H. Paulino ◽  
Marek-Jerzy Pindera ◽  
...  
Keyword(s):  
Functionally Graded Materials ◽  
Probabilistic Analysis ◽  
Fracture Analysis ◽  
Functionally Graded ◽  
Analysis Method ◽  
Graded Materials

scholarly journals A genome-wide mutation analysis method enabling high-throughput identification of chemical mutagen signatures

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Shoji Matsumura ◽  
Yurika Fujita ◽  
Masayuki Yamane ◽  
Osamu Morita ◽  
Hiroshi Honda
Keyword(s):  
Mutation Analysis ◽  
High Throughput ◽  
Chemical Mutagen ◽  
Analysis Method ◽  
Genome Wide ◽  
A Genome
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