A New Mutation Analysis Method for Testing Java Exception Handling

Author(s):  
Changbing Ji ◽  
Zhenyu Chen ◽  
Baowen Xu ◽  
Ziyuan Wang
Author(s):  
Hasan Akduman ◽  
Dilek Dilli ◽  
Serdar Ceylaner

AbstractCongenital glucose-galactose malabsorption (CGGM) is an autosomal recessive disorder originating from an abnormal transporter mechanism in the intestines. It was sourced from a mutation in the SLC5A1 gene, which encodes a sodium-dependent glucose transporter. Here we report a 2-day-old girl with CGGM who presented with severe hypernatremic dehydration due to diarrhea beginning in the first hours of life. Mutation analysis revealed a novel homozygous mutation NM_000343.3 c.127G > A (p.Gly43Arg) in the SLC5A1 gene. Since CGGM can cause fatal diarrhea in the early neonatal period, timely diagnosis of the disease seems to be essential.


2010 ◽  
Vol 10 ◽  
pp. 2003-2018 ◽  
Author(s):  
Malgorzata Marcinkowska ◽  
Kwok-Kin Wong ◽  
David J. Kwiatkowski ◽  
Piotr Kozlowski

Multiplex ligation-dependent probe amplification (MLPA) is a multiplex copy number analysis method that is routinely used to identify large mutations in many clinical and research labs. One of the most important drawbacks of the standard MLPA setup is a complicated, and therefore expensive, procedure of generating long MLPA probes. This drawback substantially limits the applicability of MLPA to those genomic regions for which ready-to-use commercial kits are available. Here we present a simple protocol for designing MLPA probe sets that are composed entirely of short oligonucleotide half-probes generated through chemical synthesis. As an example, we present the design and generation of an MLPA assay for parallel copy number and small-mutation analysis of theEGFRgene.


2005 ◽  
Vol 14 (1) ◽  
pp. 23-25 ◽  
Author(s):  
Myriam Chaabouni ◽  
Nizar Smaoui ◽  
Neila Benneji ◽  
Ridha M??rad ◽  
Lamia Ben Jemaa ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Monalisa Sarma

In general, modern programs are large and complex and it is essential that they should be highly reliable in applications. In order to develop highly reliable software, Java programming language developer provides a rich set of exceptions and exception handling mechanisms. Exception handling mechanisms are intended to help developers build robust programs. Given a program with exception handling constructs, for an effective testing, we are to detect whether all possible exceptions are raised and caught or not. However, complex exception handling constructs make it tedious to trace which exceptions are handled and where and which exceptions are passed on. In this paper, we address this problem and propose a mutation analysis approach to develop reliable object-oriented programs. We have applied a number of mutation operators to create a large set of mutant programs with different type of faults. We then generate test cases and test data to uncover exception related faults. The test suite so obtained is applied to the mutant programs measuring the mutation score and hence verifying whether mutant programs are effective or not. We have tested our approach with a number of case studies to substantiate the efficacy of the proposed mutation analysis technique.


Author(s):  
Hsiu-Yi Lin ◽  
Chun-Yao Wang ◽  
Shih-Chieh Chang ◽  
Yung-Chih Chen ◽  
Hsuan-Ming Chou ◽  
...  

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Shoji Matsumura ◽  
Yurika Fujita ◽  
Masayuki Yamane ◽  
Osamu Morita ◽  
Hiroshi Honda

Haemophilia ◽  
2001 ◽  
Vol 7 (1) ◽  
pp. 20-25 ◽  
Author(s):  
S. Oranwiroon ◽  
V. Akkarapatumwong ◽  
P. Pung-Amritt ◽  
A. Treesucon ◽  
G. Veerakul ◽  
...  

1998 ◽  
Vol 5 (1) ◽  
pp. 140A-140A ◽  
Author(s):  
J STELLING ◽  
B BHAGAVATH ◽  
M GRAY ◽  
R REINDOLLAR
Keyword(s):  

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