High resolution OCT imaging using a spectrally broadened femtosecond Nd:glass laser

2003 ◽  
Author(s):  
I. Hartl ◽  
R. Hsiung ◽  
T.H. Ko ◽  
J.G. Fujimoto ◽  
T.A. Birks ◽  
...  
Keyword(s):  
High Resolution ◽  
Oct Imaging ◽  
High Resolution Oct ◽  
Nd:Glass Laser

High-speed high-resolution OCT imaging of the retina with frequency swept lasers at 850 nm

2007 ◽  
Author(s):  
V. J. Srinivasan ◽  
R. Huber ◽  
I. Gorczynska ◽  
D. Adler ◽  
J. Y. Jiang ◽  
...  
Keyword(s):  
High Resolution ◽  
High Speed ◽  
Oct Imaging ◽  
High Resolution Oct

scholarly journals Light-Induced Thickening of Photoreceptor Outer Segment Layer Detected by Ultra-High Resolution OCT Imaging

2016 ◽  
Vol 57 (9) ◽  
pp. OCT105 ◽  
Author(s):  
Yichao Li ◽  
Robert N. Fariss ◽  
Jennifer W. Qian ◽  
Ethan D. Cohen ◽  
Haohua Qian
Keyword(s):  
High Resolution ◽  
Outer Segment ◽  
Photoreceptor Outer Segment ◽  
Oct Imaging ◽  
High Resolution Oct

scholarly journals Three-dimensional high resolution OCT imaging of macular pathology

2009 ◽  
Vol 17 (5) ◽  
pp. 4037 ◽  
Author(s):  
C. Ahlers ◽  
U. Schmidt-Erfurth
Keyword(s):  
High Resolution ◽  
Three Dimensional ◽  
Oct Imaging ◽  
High Resolution Oct

scholarly journals High-Resolution Quantitative Mapping of Macaque Cervicovaginal Epithelial Thickness: Implications for Mucosal Vaccine Delivery

2021 ◽  
Vol 12 ◽  
Author(s):  
Kathleen L. Vincent ◽  
Patrice A. Frost ◽  
Massoud Motamedi ◽  
Edward J. Dick ◽  
Jingna Wei ◽  
...  
Keyword(s):  
High Resolution ◽  
Immune Responses ◽  
Real Time ◽  
Basal Layer ◽  
Mucosal Vaccine ◽  
P Value ◽  
Mechanical Abrasion ◽  
Mucosal Vaccination ◽  
Epithelial Thickness ◽  
Oct Imaging

Vaginal mucosal surfaces naturally offer some protection against sexually transmitted infections (STIs) including Human Immunodeficiency Virus-1, however topical preventative medications or vaccine designed to boost local immune responses can further enhance this protection. We previously developed a novel mucosal vaccine strategy using viral vectors integrated into mouse dermal epithelium to induce virus-specific humoral and cellular immune responses at the site of exposure. Since vaccine integration occurs at the site of cell replication (basal layer 100-400 micrometers below the surface), temporal epithelial thinning during vaccine application, confirmed with high resolution imaging, is desirable. In this study, strategies for vaginal mucosal thinning were evaluated noninvasively using optical coherence tomography (OCT) to map reproductive tract epithelial thickness (ET) in macaques to optimize basal layer access in preparation for future effective intravaginal mucosal vaccination studies. Twelve adolescent female rhesus macaques (5-7kg) were randomly assigned to interventions to induce vaginal mucosal thinning, including cytobrush mechanical abrasion, the chemical surfactant spermicide nonoxynol-9 (N9), the hormonal contraceptive depomedroxyprogesterone acetate (DMPA), or no intervention. Macaques were evaluated at baseline and after interventions using colposcopy, vaginal biopsies, and OCT imaging, which allowed for real-time in vivo visualization and measurement of ET of the mid-vagina, fornices, and cervix. P value ≤0.05 was considered significant. Colposcopy findings included pink, rugated tissue with variable degrees of white-tipped, thickened epithelium. Baseline ET of the fornices was thinner than the cervix and vagina (p<0.05), and mensing macaques had thinner ET at all sites (p<0.001). ET was decreased 1 month after DMPA (p<0.05) in all sites, immediately after mechanical abrasion (p<0.05) in the fornix and cervix, and after two doses of 4% N9 (1.25ml) applied over 14 hrs in the fornix only (p<0.001). Histological assessment of biopsied samples confirmed OCT findings. In summary, OCT imaging allowed for real time assessment of macaque vaginal ET. While varying degrees of thinning were observed after the interventions, limitations with each were noted. ET decreased naturally during menses, which may provide an ideal opportunity for accessing the targeted vaginal mucosal basal layers to achieve the optimum epithelial thickness for intravaginal mucosal vaccination.

Slit-Lamp–Adapted Ultra-High Resolution OCT for Imaging the Posterior Segment of the Eye

2012 ◽  
Vol 43 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Hong Jiang ◽  
Fawzi Abukhalil ◽  
Meixiao Shen ◽  
Giovanni Gregori ◽  
Byron L. Lam ◽  
...  
Keyword(s):  
High Resolution ◽  
Posterior Segment ◽  
Slit Lamp ◽  
High Resolution Oct

scholarly journals Advanced analysis of domain walls in Mg doped LiNbO_3 crystals with high resolution OCT

2017 ◽  
Vol 25 (13) ◽  
pp. 14871 ◽  
Author(s):  
Lars Kirsten ◽  
Alexander Haußmann ◽  
Christian Schnabel ◽  
Sebastian Schmidt ◽  
Peter Cimalla ◽  
...  
Keyword(s):  
High Resolution ◽  
Domain Walls ◽  
Advanced Analysis ◽  
High Resolution Oct ◽  
Mg Doped

scholarly journals P2271Super high-resolution OCT for endothelial cell visualization in the coronary arteries

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
K Nishimiya ◽  
B Yin ◽  
Z Piao ◽  
H Osman ◽  
J Ryu ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
High Resolution ◽  
Coronary Arteries ◽  
High Resolution Oct

scholarly journals Reliability of manual segmentation of cornea, contact lens and tear film using a high-resolution OCT

2015 ◽  
Vol 62 (21) ◽  
pp. 1808-1815 ◽  
Author(s):  
Patrícia Rodrigues ◽  
Daniela Lopes-Ferreira ◽  
Andreia Catarino ◽  
Alejandro Cervino ◽  
Antonio Queirós ◽  
...  
Keyword(s):  
High Resolution ◽  
Contact Lens ◽  
Tear Film ◽  
Manual Segmentation ◽  
High Resolution Oct
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