scholarly journals The Intracellular Immune Receptor Sw-5b Confers Broad-Spectrum Resistance to Tospoviruses through Recognition of a Conserved 21-Amino Acid Viral Effector Epitope

2017 ◽  
Vol 29 (9) ◽  
pp. 2214-2232 ◽  
Author(s):  
Min Zhu ◽  
Lei Jiang ◽  
Baohui Bai ◽  
Wenyang Zhao ◽  
Xiaojiao Chen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Broad Spectrum ◽  
Immune Receptor ◽  
Broad Spectrum Resistance

scholarly journals In70 of Plasmid pAX22, ablaVIM-1-Containing Integron Carrying a New Aminoglycoside Phosphotransferase Gene Cassette

2001 ◽  
Vol 45 (4) ◽  
pp. 1249-1253 ◽  
Author(s):  
Maria Letizia Riccio ◽  
Lucia Pallecchi ◽  
Roberta Fontana ◽  
Gian Maria Rossolini
Keyword(s):  
Amino Acid ◽  
Broad Spectrum ◽  
Gene Cassette ◽  
Amino Acid Identity ◽  
University Hospital ◽  
Acid Identity ◽  
Aminoglycoside Phosphotransferase ◽  
Broad Spectrum Resistance ◽  
Class 1

ABSTRACT An Achromobacter xylosoxydans strain showing broad-spectrum resistance to β-lactams (including carbapenems) and aminoglycosides was isolated at the University Hospital of Verona (Verona, Italy). This strain was found to produce metallo-β-lactamase activity and to harbor a 30-kb nonconjugative plasmid, named pAX22, carrying abla VIM-1 determinant inserted into a class 1 integron. Characterization of this integron, named In70, revealed an original array of four gene cassettes containing, respectively, thebla VIM-1 gene and three different aminoglycoside resistance determinants, including an aacA4allele, a new aph-like gene named aphA15, and an aadA1 allele. The aphA15 gene is the first example of an aph-like gene carried on a mobile gene cassette, and its product exhibits close similarity to the APH(3′)-IIa aminoglycoside phosphotransferase encoded by Tn5 (36% amino acid identity) and to an APH(3′)-IIb enzyme fromPseudomonas aeruginosa (38% amino acid identity). Expression of the cloned aphA15 gene in Escherichia coli reduced the susceptibility to kanamycin and neomycin as well as (slightly) to amikacin, netilmicin, and streptomycin. Characterization of the 5′ and 3′ conserved segments of In70 and of their flanking regions showed that In70 belongs to the group of class 1 integrons associated with defective transposon derivatives originating from Tn402-like elements. The structure of the 3′ conserved segment indicates the closest ancestry with members of the In0-In2 lineage. In70, with its array of cassette-borne resistance genes, can mediate broad-spectrum resistance to most β-lactams and aminoglycosides.

scholarly journals A new amino acid substitution (Ala-205-Phe) in acetolactate synthase (ALS) confers broad spectrum resistance to ALS-inhibiting herbicides

Planta ◽  
2015 ◽  
Vol 243 (1) ◽  
pp. 149-159 ◽  
Author(s):  
James T. Brosnan ◽  
Jose J. Vargas ◽  
Gregory K. Breeden ◽  
Logan Grier ◽  
Raphael A. Aponte ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Substitution ◽  
Broad Spectrum ◽  
Acetolactate Synthase ◽  
Broad Spectrum Resistance

scholarly journals RNAi‐mediated stable silencing of TaCSN5 confers broad‐spectrum resistance to Puccinia striiformis f. sp. tritici

2021 ◽  
Author(s):  
Xingxuan Bai ◽  
Xueling Huang ◽  
Shuxin Tian ◽  
Huan Peng ◽  
Gangming Zhan ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Puccinia Striiformis ◽  
Broad Spectrum Resistance

scholarly journals Engineering broad-spectrum resistance to cotton leaf curl disease by CRISPR-Cas9 based multiplex editing in plants

2021 ◽  
pp. 1-12
Author(s):  
Muhammad Salman Mubarik ◽  
Xiukang Wang ◽  
Sultan Habibullah Khan ◽  
Aftab Ahmad ◽  
Zulqurnain Khan ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Cotton Leaf ◽  
Broad Spectrum Resistance ◽  
Cotton Leaf Curl Disease ◽  
Leaf Curl Disease ◽  
Leaf Curl
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