Andreev scattering, Josephson currents, and coupling energy in clean superconductor-semiconductor-superconductor junctions

1993 ◽  
Vol 47 (5) ◽  
pp. 2754-2759 ◽  
Author(s):  
U. Schüssler ◽  
R. Kümmel
Keyword(s):  
Coupling Energy ◽  
Andreev Scattering

scholarly journals Horndeski genesis: consistency of classical theory

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Yulia Ageeva ◽  
Pavel Petrov ◽  
Valery Rubakov
Keyword(s):  
Strong Coupling ◽  
Dimensional Analysis ◽  
Classical Theory ◽  
Arbitrary Order ◽  
Specific Model ◽  
Power Counting ◽  
Coupling Energy ◽  
Classical Description ◽  
Higher Order Terms ◽  
The Universe

Abstract Genesis within the Horndeski theory is one of possible scenarios for the start of the Universe. In this model, the absence of instabilities is obtained at the expense of the property that coefficients, serving as effective Planck masses, vanish in the asymptotics t → −∞, which signalizes the danger of strong coupling and inconsistency of the classical treatment. We investigate this problem in a specific model and extend the analysis of cubic action for perturbations (arXiv:2003.01202) to arbitrary order. Our study is based on power counting and dimensional analysis of the higher order terms. We derive the latter, find characteristic strong coupling energy scales and obtain the conditions for the validity of the classical description. Curiously, we find that the strongest condition is the same as that obtained in already examined cubic case.

Molecular packing in crystals of the aromatic hydrocarbons

1965 ◽  
Vol 286 (1404) ◽  
pp. 98-116 ◽  
Keyword(s):  
Van Der Waals ◽  
Equilibrium Structure ◽  
Group Symmetry ◽  
Structural Variations ◽  
Angular Variation ◽  
Coupling Energy ◽  
Quadrupole Interactions ◽  
Quadrupole Coupling ◽  
Cell Dimensions ◽  
Unit Cell Dimensions

The van der Waals energy, quadrupole-quadrupole coupling energy, and hydrogen-hydrogen repulsions have been calculated for the equilibrium structure of crystalline naphthalene and for several displaced structures. The displacements are small rotations of the molecules about their symmetry axes, phased so that the space-group symmetry and unit-cell dimensions are preserved. For structural variations of this type the hydrogen-hydrogen repulsions have a strong minimum within a few degrees angular variation from equilibrium, indicating that these repulsions are dominant and determine the crystal structure for this class of displacement. The attractive van der Waals and quadrupole interactions on the other hand are not minimized at the equilibrium structure; they vary slowly (by a few wavenumbers per degree rotation) and approximately linearly.

scholarly journals Acetylcholine Receptor Gating at Extracellular Transmembrane Domain Interface: the “Pre-M1” Linker

2007 ◽  
Vol 130 (6) ◽  
pp. 559-568 ◽  
Author(s):  
Prasad Purohit ◽  
Anthony Auerbach
Keyword(s):  
Acetylcholine Receptors ◽  
State Energy ◽  
Transmembrane Domain ◽  
Salt Bridge ◽  
Side Chain ◽  
Coupling Energy ◽  
And Function ◽  
Loop 2 ◽  
Α Subunits ◽  
Α1 Subunit

Charged residues in the β10–M1 linker region (“pre-M1”) are important in the expression and function of neuromuscular acetylcholine receptors (AChRs). The perturbation of a salt bridge between pre-M1 residue R209 and loop 2 residue E45 has been proposed as being a principle event in the AChR gating conformational “wave.” We examined the effects of mutations to all five residues in pre-M1 (positions M207–P211) plus E45 in loop 2 in the mouse α1-subunit. M207, Q208, and P211 mutants caused small (approximately threefold) changes in the gating equilibrium constant (Keq), but the changes for R209, L210, and E45 were larger. Of 19 different side chain substitutions at R209 on the wild-type background, only Q, K, and H generated functional channels, with the largest change in Keq (67-fold) from R209Q. Various R209 mutants were functional on different E45 backgrounds: H, Q, and K (E45A), H, A, N, and Q (E45R), and K, A, and N (E45L). Φ values for R209 (on the E45A background), L210, and E45 were 0.74, 0.35, and 0.80, respectively. Φ values for R209 on the wt and three other backgrounds could not be estimated because of scatter. The average coupling energy between 209/45 side chains (six different pairs) was only −0.33 kcal/mol (for both α subunits, combined). Pre-M1 residues are important for expression of functional channels and participate in gating, but the relatively modest changes in closed- vs. open-state energy caused mutations, the weak coupling energy between these residues and the functional activity of several unmatched-charge pairs are not consistent with the perturbation of a salt bridge between R209 and E45 playing the principle role in gating.

scholarly journals Angle dependence of Andreev scattering at semiconductor–superconductor interfaces

1999 ◽  
Vol 59 (15) ◽  
pp. 10176-10182 ◽  
Author(s):  
Niels Asger Mortensen ◽  
Karsten Flensberg ◽  
Antti-Pekka Jauho
Keyword(s):  
Angle Dependence ◽  
Andreev Scattering

Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1

FEBS Journal ◽  
2010 ◽  
Vol 277 (19) ◽  
pp. 3974-3985 ◽  
Author(s):  
Emily Crowley ◽  
Megan L. O’Mara ◽  
Ian D. Kerr ◽  
Richard Callaghan
Keyword(s):  
Transmembrane Helix ◽  
Drug Binding ◽  
Pivotal Role ◽  
Coupling Energy ◽  
Helix 12

scholarly journals Andreev scattering in nanoscopic junctions in a magnetic field

2000 ◽  
Vol 50 (6) ◽  
pp. 749-755 ◽  
Author(s):  
H Suderow ◽  
E Bascones ◽  
W Belzig ◽  
F Guinea ◽  
S Vieira
Keyword(s):  
Magnetic Field ◽  
Andreev Scattering

scholarly journals The transcription factors TFEB and TFE3 link the FLCN-AMPK signaling axis to innate immune response and pathogen resistance

2018 ◽  
Author(s):  
Leeanna El-Houjeiri ◽  
Elite Possik ◽  
Tarika Vijayaraghavan ◽  
Mathieu Paquette ◽  
José A Martina ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Mammalian Cells ◽  
Pathogen Resistance ◽  
Innate Immune ◽  
Negative Regulator ◽  
Energy Status ◽  
Rapid Reduction ◽  
Coupling Energy ◽  
Mtorc1 Signaling

AbstractTFEB and TFE3 are transcriptional regulators of the innate immune response, but the mechanisms regulating their activation upon pathogen infection are poorly elucidated. UsingC. elegansand mammalian models, we report that the master metabolic modulator 5’-AMP-activated protein kinase (AMPK) and its negative regulator Folliculin (FLCN) act upstream of TFEB/TFE3 in the innate immune response, independently of the mTORC1 signaling pathway. In nematodes, loss of FLCN or overexpression of AMPK conferred pathogen resistanceviaactivation of TFEB/TFE3-dependent antimicrobial genes, while ablation of total AMPK activity abolished this phenotype. Similarly, in mammalian cells, loss of FLCN or pharmacological activation of AMPK induced TFEB/TFE3-dependent pro-inflammatory cytokine expression. Importantly, a rapid reduction in cellular ATP levels in murine macrophages was observed upon lipopolysaccharide (LPS) treatment accompanied by an acute AMPK activation and TFEB nuclear localization. These results uncover an ancient, highly conserved and pharmacologically actionable mechanism coupling energy status with innate immunity.

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