scholarly journals Noninvasive Quantitative Imaging of Selective Microstructure Sizes via Magnetic Resonance

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Milena Capiglioni ◽  
Analia Zwick ◽  
Pablo Jiménez ◽  
Gonzalo A. Álvarez
Keyword(s):  
Magnetic Resonance ◽  
Quantitative Imaging

scholarly journals High field magnetic resonance microscopy of the human hippocampus in Alzheimer's disease: Quantitative imaging and correlation with iron

NeuroImage ◽  
2012 ◽  
Vol 59 (2) ◽  
pp. 1249-1260 ◽  
Author(s):  
Vijay Antharam ◽  
Joanna F. Collingwood ◽  
John-Paul Bullivant ◽  
Mark R. Davidson ◽  
Saurav Chandra ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
High Field ◽  
Quantitative Imaging ◽  
Magnetic Resonance Microscopy ◽  
Human Hippocampus

Clinical Application of Information Medicine Cardiac Magnetic Resonance Quantitative Imaging in Central Nervous System Cardiology Cardiomyopathy

2021 ◽  
Vol 11 (2) ◽  
pp. 623-629
Author(s):  
Jianhong Shen ◽  
Zanfei Li ◽  
Xianliang Ren
Keyword(s):  
Central Nervous System ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Systolic Function ◽  
Quantitative Imaging ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Diffuse Fibrosis ◽  
Ventricular Systolic Function ◽  
The Relationship

Objective: To study the left ventricular systolic function in patients with central nervous system endocarditis myocarditis by using information-based cardiac magnetic resonance quantitative imaging technique. LGE and T1 mapping techniques were used to evaluate myocardial localized fibrosis and diffuse fibrosis, respectively. The situation is to explore the limitations and the relationship between diffuse cardiomyopathy and cardiac function. Methods: A total of 44 patients with dilated cardiomyopathy and 23 healthy volunteers were scanned with a magnetic resonance imager to determine the occurrence of focal myocardial and diffuse fibrosis, and to analyze the relationship between left ventricular systolic function and left ventricular systolic function. Relationship. Results: The TML values (1335.23 ± 60.91 ms) and LGE (–) subgroups (1309.05 ± 55.02 ms) in the DCMLGE(+) subgroup were significantly different from those in the control group (P < 0.001); however, DCMLGE ( There was no significant difference in the myocardial T1 values between the + and LGE (–) groups (P > 0.05). Conclusion: Cardiac magnetic resonance quantitative imaging technology can reflect the diffuse fibrosis of patients with cardiomyopathy, and can detect early myocardial fibrosis early. In addition, patients with cardiomyopathy have myocardial limitations and diffuse fibrosis, which affects the contractile function of the left ventricle of the heart.

scholarly journals Quantitative imaging of tumour blood flow by contrast-enhanced magnetic resonance imaging

2001 ◽  
Vol 85 (11) ◽  
pp. 1655-1663 ◽  
Author(s):  
S Pahernik ◽  
J Griebel ◽  
A Botzlar ◽  
T Gneiting ◽  
M Brandl ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Magnetic Resonance ◽  
Quantitative Imaging ◽  
Resonance Imaging ◽  
Tumour Blood Flow ◽  
Contrast Enhanced ◽  
Tumour Blood

scholarly journals Feasibility of synthetic MRI in knee imaging in routine practice

2018 ◽  
Vol 7 (5) ◽  
pp. 205846011876968 ◽  
Author(s):  
Sana Boudabbous ◽  
Angeliki Neroladaki ◽  
Ilias Bagetakos ◽  
Marion Hamard ◽  
Bénédicte MA Delattre ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Cruciate Ligament ◽  
Quantitative Imaging ◽  
Proton Density ◽  
Routine Practice ◽  
Synthetic Sequence ◽  
Magnetic Resonance Imaging Mri ◽  
Anterior Cruciate ◽  
Knee Imaging ◽  
Synthetic Mri

Background Synthetic magnetic resonance (MR) is a method allowing reduction of examination time and access to quantitative imaging. Purpose This study sought to assess the image quality and diagnostic accuracy of synthetic magnetic resonance imaging (MRI) compared to standard MRI in patients with knee pain. Material and Methods In total, 22 patients underwent standard 1.5 knee MRI with an added synthetic sequence. Quantitative T1, T2, and proton density (PD) images were generated synthetically; T1, PD, and short tau inversion recovery (STIR) weighted images were created with chosen echo time (TE), repetition time (TR), and inversion time (TI). Two blinded musculoskeletal radiologists evaluated the overall sequence quality, visualization of anatomic structures, and presence of artifacts using a 3-point score. Results The synthetic sequence was acquired in 39% less time than the conventional MRI. Synthetic PD, T1, and STIR images were rated fair (2%, 5%, and 2%, respectively) or good quality (98%, 95%, and 98%, respectively), despite the presence of popliteal artery artifacts. Cartilage and meniscus were well visualized in all cases. Anterior cruciate ligament visualization was rated poor in 7%, 14%, and 30% of PD, STIR, and T1 images, respectively. Conclusion Our pilot study confirmed the feasibility of synthetic MRI in knee examinations, proving faster and achieving appropriate quality and good diagnostic confidence.

scholarly journals Nuclear Microscopy: A Novel Technique for Quantitative Imaging of Gadolinium Distribution within Tissue Sections

2009 ◽  
Vol 15 (4) ◽  
pp. 338-344 ◽  
Author(s):  
Reshmi Rajendran ◽  
John A. Ronald ◽  
Tao Ye ◽  
Ren Minqin ◽  
John W. Chen ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
Rutherford Backscattering Spectrometry ◽  
Ion Beam ◽  
Quantitative Imaging ◽  
High Energy ◽  
Nuclear Microscopy ◽  
Scanning Transmission ◽  
Magnetic Resonance Imaging Mri

AbstractAll clinically-approved and many novel gadolinium (Gd)-based contrast agents used to enhance signal intensity in magnetic resonance imaging (MRI) are optically silent. To verify MRI results, a “gold standard” that can map and quantify Gd down to the parts per million (ppm) levels is required. Nuclear microscopy is a relatively new technique that has this capability and is composed of a combination of three ion beam techniques: scanning transmission ion microscopy, Rutherford backscattering spectrometry, and particle induced X-ray emission used in conjunction with a high energy proton microprobe. In this proof-of-concept study, we show that in diseased aortic vessel walls obtained at 2 and 4 h after intravenous injection of the myeloperoxidase-senstitive MRI agent, bis-5-hydroxytryptamide-diethylenetriamine-pentaacetate gadolinium, there was a time-dependant Gd clearance (2 h = 18.86 ppm, 4 h = 8.65 ppm). As expected, the control animal, injected with the clinically-approved conventional agent diethylenetriamine-pentaacetate gadolinium and sacrificed 1 week after injection, revealed no significant residual Gd in the tissue. Similar to known in vivo Gd pharmacokinetics, we found that Gd concentration dropped by a factor of 2 in vessel wall tissue in 1.64 h. Further high-resolution studies revealed that Gd was relatively uniformly distributed, consistent with random agent diffusion. We conclude that nuclear microscopy is potentially very useful for validation studies involving Gd-based magnetic resonance contrast agents.

scholarly journals Quantitative Imaging of Cell-Permeable Magnetic Resonance Contrast Agents Using X-Ray Fluorescence

2006 ◽  
Vol 5 (4) ◽  
pp. 7290.2006.00026 ◽  
Author(s):  
Paul J. Endres ◽  
Keith W. MacRenaris ◽  
Stefan Vogt ◽  
Matthew J. Allen ◽  
Thomas J. Meade
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
Quantitative Imaging ◽  
X Ray ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast

scholarly journals Direct magnetic resonance detection of myelin and prospects for quantitative imaging of myelin density

2012 ◽  
Vol 109 (24) ◽  
pp. 9605-9610 ◽  
Author(s):  
M. J. Wilhelm ◽  
H. H. Ong ◽  
S. L. Wehrli ◽  
C. Li ◽  
P.-H. Tsai ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Quantitative Imaging ◽  
Resonance Detection

scholarly journals Metabolic Imaging in Non-Alcoholic Fatty Liver Disease: Applications of Magnetic Resonance Spectroscopy

2021 ◽  
Vol 10 (4) ◽  
pp. 632
Author(s):  
Prarthana Thiagarajan ◽  
Stephen J. Bawden ◽  
Guruprasad P. Aithal
Keyword(s):  
Liver Disease ◽  
Magnetic Resonance ◽  
Natural History ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Quantitative Imaging ◽  
Imaging Biomarkers ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is poised to dominate the landscape of clinical hepatology in the 21st century. Its complex, interdependent aetiologies, non-linear disease progression and uncertain natural history have presented great challenges to the development of effective therapies. Progress will require an integrated approach to uncover molecular mediators, key pathogenic milestones and response to intervention at the metabolic level. The advent of precision imaging has yielded unprecedented insights into these processes. Quantitative imaging biomarkers such as magnetic resonance imaging (MRI), spectroscopy (MRS) and elastography (MRE) present robust, powerful tools with which to probe NAFLD metabolism and fibrogenesis non-invasively, in real time. Specific advantages of MRS include the ability to quantify static metabolite concentrations as well as dynamic substrate flux in vivo. Thus, a vast range of key metabolic events in the natural history of NAFLD can be explored using MRS. Here, we provide an overview of MRS for the clinician, as well as key pathways exploitable by MRS in vivo. Development, optimisation and validation of multinuclear MRS, in combination with other quantitative imaging techniques, may ultimately provide a robust, non-invasive alternative to liver biopsy for observational and longitudinal studies. Through enabling deeper insight into inflammatory and fibrogenic cascades, MRS may facilitate identification of novel therapeutic targets and clinically meaningful endpoints in NAFLD. Its widespread use in future could conceivably accelerate study design, data acquisition and availability of disease-modifying therapies at a population level.

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