Quantitative Imaging Metrics Derived from Magnetic Resonance Fingerprinting using ISMRM/NIST MRI System Phantom: An International Multi‐Center Repeatability and Reproducibility Study

2021 ◽  
Author(s):  
Amaresha Shridhar Konar ◽  
Enlin Qian ◽  
Sairam Geethanath ◽  
Guido Buonincontri ◽  
Nancy A. Obuchowski ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Quantitative Imaging ◽  
Reproducibility Study ◽  
Repeatability And Reproducibility

scholarly journals Noninvasive Quantitative Imaging of Selective Microstructure Sizes via Magnetic Resonance

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Milena Capiglioni ◽  
Analia Zwick ◽  
Pablo Jiménez ◽  
Gonzalo A. Álvarez
Keyword(s):  
Magnetic Resonance ◽  
Quantitative Imaging

scholarly journals High field magnetic resonance microscopy of the human hippocampus in Alzheimer's disease: Quantitative imaging and correlation with iron

NeuroImage ◽  
2012 ◽  
Vol 59 (2) ◽  
pp. 1249-1260 ◽  
Author(s):  
Vijay Antharam ◽  
Joanna F. Collingwood ◽  
John-Paul Bullivant ◽  
Mark R. Davidson ◽  
Saurav Chandra ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
High Field ◽  
Quantitative Imaging ◽  
Magnetic Resonance Microscopy ◽  
Human Hippocampus

scholarly journals Assessment of the Adequacy of Gauge Repeatability and Reproducibility Study Using a Monte Carlo Simulation

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Chunghun Ha ◽  
David S. Kim ◽  
SeJoon Park
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
System Analysis ◽  
Performance Metrics ◽  
Repeated Measurements ◽  
Percentage Error ◽  
Nested Design ◽  
Reproducibility Study ◽  
Measurement System Analysis ◽  
Repeatability And Reproducibility

ANOVA gauge repeatability and reproducibility study is the most popular tool for measurement system analysis. Two experimental designs can be applied depending on the durability of the objects. If repeated measurements are possible or sufficient homogeneous nonrepeatable samples are available, crossed design is appropriate; otherwise, nested design should be used. In this paper, we investigated the adequacy of ANOVA gauge repeatability and reproducibility study from the perspective of practitioners. We proposed a Monte Carlo simulation that is close to the realistic procedure to evaluate the adequacy of both structures. During the evaluation, we considered the average performance metrics, percentage of correct decision, histogram shape, and symmetric mean absolute percentage error for the four popular performance metrics, namely, % Study Variation, % Contribution, % Tolerance, and the number of distinct categories. The experimental results show that the nested design fails to judge the precision of the gauge while the crossed design succeeds.

scholarly journals Fick versus flow: a real-time invasive cardiovascular magnetic resonance (iCMR) reproducibility study

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Yousef Arar ◽  
Tarique Hussain ◽  
Riad Abou Zahr ◽  
Vasu Gooty ◽  
Joshua S. Greer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiovascular Magnetic Resonance ◽  
Magnetic Resonance ◽  
Real Time ◽  
Correlation Coefficients ◽  
Flow Quantification ◽  
Heart Catheterization ◽  
Saturation Pulse ◽  
Fick Principle ◽  
Reproducibility Study

Abstract Background Cardiac catheterization and cardiovascular magnetic resonance (CMR) imaging have distinct diagnostic roles in the congenital heart disease (CHD) population. Invasive CMR (iCMR) allows for a more thorough assessment of cardiac hemodynamics at the same time under the same conditions. It is assumed but not proven that iCMR gives an incremental value by providing more accurate flow quantification. Methods Subjects with CHD underwent real-time 1.5 T iCMR using a passive catheter tracking technique with partial saturation pulse of 40° to visualize the gadolinium-filled balloon, CMR-conditional guidewire, and cardiac structures simultaneously to aid in completion of right (RHC) and left heart catheterization (LHC). Repeat iCMR and catheterization measurements were performed to compare reliability by the Pearson (PCC) and concordance correlation coefficients (CCC). Results Thirty CHD (20 single ventricle and 10 bi-ventricular) subjects with a median age and weight of 8.3 years (2–33) and 27.7 kg (9.2–80), respectively,  successfully underwent iCMR RHC and LHC. No catheter related complications were encountered. Time taken for first pass RHC and LHC/aortic pull back was 5.1, and 2.9 min, respectively. Total success rate to obtain required data points to complete Fick principle calculations for all patients was 321/328 (98%). One patient with multiple shunts was an outlier and excluded from further analysis. The PCC for catheter-derived pulmonary blood flow (Qp) (0.89, p < 0.001) is slightly lower than iCMR-derived Qp (0.96, p < 0.001), whereas catheter-derived systemic blood flow (Qs) (0.62, p = < 0.001) was considerably lower than iCMR-derived Qs (0.94, p < 0.001). CCC agreement for Qp at baseline (C1-CCC = 0.65, 95% CI 0.41–0.81) and retested conditions (C2-CCC = 0.78, 95% CI 0.58–0.89) were better than for Qs at baseline (C1-CCC = 0.22, 95% CI − 0.15–0.53) and retested conditions (C2-CCC = 0.52, 95% CI 0.17–0.76). Conclusion This study further validates hemodynamic measurements obtained via iCMR. iCMR-derived flows have considerably higher test–retest reliability for Qs. iCMR evaluations allow for more reproducible hemodynamic assessments in the CHD population.

Clinical Application of Information Medicine Cardiac Magnetic Resonance Quantitative Imaging in Central Nervous System Cardiology Cardiomyopathy

2021 ◽  
Vol 11 (2) ◽  
pp. 623-629
Author(s):  
Jianhong Shen ◽  
Zanfei Li ◽  
Xianliang Ren
Keyword(s):  
Central Nervous System ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Systolic Function ◽  
Quantitative Imaging ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Diffuse Fibrosis ◽  
Ventricular Systolic Function ◽  
The Relationship

Objective: To study the left ventricular systolic function in patients with central nervous system endocarditis myocarditis by using information-based cardiac magnetic resonance quantitative imaging technique. LGE and T1 mapping techniques were used to evaluate myocardial localized fibrosis and diffuse fibrosis, respectively. The situation is to explore the limitations and the relationship between diffuse cardiomyopathy and cardiac function. Methods: A total of 44 patients with dilated cardiomyopathy and 23 healthy volunteers were scanned with a magnetic resonance imager to determine the occurrence of focal myocardial and diffuse fibrosis, and to analyze the relationship between left ventricular systolic function and left ventricular systolic function. Relationship. Results: The TML values (1335.23 ± 60.91 ms) and LGE (–) subgroups (1309.05 ± 55.02 ms) in the DCMLGE(+) subgroup were significantly different from those in the control group (P < 0.001); however, DCMLGE ( There was no significant difference in the myocardial T1 values between the + and LGE (–) groups (P > 0.05). Conclusion: Cardiac magnetic resonance quantitative imaging technology can reflect the diffuse fibrosis of patients with cardiomyopathy, and can detect early myocardial fibrosis early. In addition, patients with cardiomyopathy have myocardial limitations and diffuse fibrosis, which affects the contractile function of the left ventricle of the heart.

Measuring Uncertainty Using Different Approaches: A Case Study for Acetaminophen Quantification

2016 ◽  
Vol 99 (3) ◽  
pp. 612-617 ◽  
Author(s):  
Fabiane Lacerda Francisco ◽  
Alessandro Morais Saviano ◽  
Felipe Rebello Lourenço
Keyword(s):  
Measurement Uncertainty ◽  
Uncertainty Estimation ◽  
Pharmaceutical Drug ◽  
Drug Products ◽  
Pharmaceutical Equivalence ◽  
Reproducibility Study ◽  
Repeatability And Reproducibility ◽  
Analytical Result ◽  
Measurement Uncertainty Estimation

Abstract Investigation of out-of-specification analytical results is laborious, time-consuming, and costly and must be well documented. However, an analytical result is not complete unless reported with its measurement uncertainty. Here, we compare four different approaches for measurement uncertainty estimation used in acetaminophen quantification in pharmaceutical drug products. Measurement uncertainties were estimated using a repeatability and reproducibility study, Eurachem/Citac guidelines, Monte Carlo simulations, and a spreadsheet method. These different approaches provided similar results. However, they differed by the sources of uncertainties considered, by the procedures of calculation, and by the effort required in routine applications. Nevertheless, all four approaches were successful in assessing conformity of acetaminophen content in pharmaceutical drug products and may be used in assessing pharmaceutical equivalence.

Magnetic resonance transverse relaxation time T2 of knee cartilage in osteoarthritis at 3-T: a cross-sectional multicentre, multivendor reproducibility study

2012 ◽  
Vol 42 (4) ◽  
pp. 511-520 ◽  
Author(s):  
Sharon Balamoody ◽  
Tomos G. Williams ◽  
Chris Wolstenholme ◽  
John C. Waterton ◽  
Michael Bowes ◽  
...  
Keyword(s):  
Relaxation Time ◽  
Magnetic Resonance ◽  
Transverse Relaxation Time ◽  
Knee Cartilage ◽  
Cross Sectional ◽  
Transverse Relaxation ◽  
Reproducibility Study

scholarly journals Quantitative imaging of tumour blood flow by contrast-enhanced magnetic resonance imaging

2001 ◽  
Vol 85 (11) ◽  
pp. 1655-1663 ◽  
Author(s):  
S Pahernik ◽  
J Griebel ◽  
A Botzlar ◽  
T Gneiting ◽  
M Brandl ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Magnetic Resonance ◽  
Quantitative Imaging ◽  
Resonance Imaging ◽  
Tumour Blood Flow ◽  
Contrast Enhanced ◽  
Tumour Blood
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