scholarly journals Quantitative imaging of tumour blood flow by contrast-enhanced magnetic resonance imaging

2001 ◽  
Vol 85 (11) ◽  
pp. 1655-1663 ◽  
Author(s):  
S Pahernik ◽  
J Griebel ◽  
A Botzlar ◽  
T Gneiting ◽  
M Brandl ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Magnetic Resonance ◽  
Quantitative Imaging ◽  
Resonance Imaging ◽  
Tumour Blood Flow ◽  
Contrast Enhanced ◽  
Tumour Blood

scholarly journals Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Jessica Buck ◽  
James R. Larkin ◽  
Manon A. Simard ◽  
Alexandre A. Khrapitchev ◽  
Michael A. Chappell ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Blood Vessels ◽  
Arterial Spin Labelling ◽  
Resonance Imaging ◽  
Tumour Blood Flow ◽  
Tumour Perfusion ◽  
Tumour Blood

Brain and tumour blood flow can be measured noninvasively using arterial spin labelling (ASL) magnetic resonance imaging (MRI), but reliable quantification in mouse models remains difficult. Pseudocontinuous ASL (pCASL) is recommended as the clinical standard for ASL and can be improved using multiphase labelling (MP pCASL). The aim of this study was to optimise and validate MP pCASL MRI for cerebral blood flow (CBF) measurement in mice and to assess its sensitivity to tumour perfusion. Following optimization of the MP pCASL sequence, CBF data were compared with gold-standard autoradiography, showing close agreement. Subsequently, MP pCASL data were acquired at weekly intervals in models of primary and secondary brain tumours, and tumour microvessel density was determined histologically. MP pCASL measurements in a secondary brain tumour model revealed a significant reduction in blood flow at day 35 after induction, despite a higher density of blood vessels. Tumour core regions also showed reduced blood flow compared with the tumour rim. Similarly, significant reductions in CBF were found in a model of glioma 28 days after tumour induction, together with an increased density of blood vessels. These findings indicate that MP pCASL MRI provides accurate and robust measurements of cerebral blood flow in naïve mice and is sensitive to changes in tumour perfusion.

Myocardial blood flow estimates from dynamic contrast-enhanced magnetic resonance imaging: three quantitative methods

2018 ◽  
Vol 63 (3) ◽  
pp. 035008 ◽  
Author(s):  
Cristian Borrazzo ◽  
Nicola Galea ◽  
Massimiliano Pacilio ◽  
Luisa Altabella ◽  
Enrico Preziosi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Magnetic Resonance ◽  
Myocardial Blood Flow ◽  
Quantitative Methods ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced
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