scholarly journals Vision affects mushroom bodies and central complex in Drosophila melanogaster.

1997 ◽  
Vol 4 (2) ◽  
pp. 219-229 ◽  
Author(s):  
M Barth ◽  
M Heisenberg
Keyword(s):  
Drosophila Melanogaster ◽  
Central Complex ◽  
Mushroom Bodies

scholarly journals Protocerebral bridge neurons that regulate sleep in Drosophila melanogaster

2020 ◽  
Author(s):  
Jun Tomita ◽  
Gosuke Ban ◽  
Yoshiaki S. Kato ◽  
Kazuhiko Kume
Keyword(s):  
Drosophila Melanogaster ◽  
Brain Regions ◽  
Central Complex ◽  
Neuronal Circuit ◽  
Sleep Regulation ◽  
Synaptic Contacts ◽  
Protocerebral Bridge ◽  
Dopamine Signaling

AbstractThe central complex is one of the major brain regions that control sleep in Drosophila, but the circuitry details of sleep regulation have yet to be elucidated. Here, we show a novel sleep-regulating neuronal circuit in the protocerebral bridge (PB) of the central complex. Activation of the PB interneurons labeled by the R59E08-Gal4 and the PB columnar neurons in the R52B10-Gal4 promoted sleep and wakefulness, respectively. A targeted GFP reconstitution across synaptic partners (t-GRASP) analysis demonstrated synaptic contacts between these two groups of sleep-regulating PB neurons. Furthermore, we found that activation of a pair of dopaminergic (DA) neurons projecting to the PB (T1 DA neurons) decreased sleep. The wake-promoting T1 DA neurons and the sleep-promoting PB interneurons formed close associations. Dopamine 2-like receptor (Dop2R) knockdown in the sleep-promoting PB interneurons increased sleep. These results indicated that the neuronal circuit in the PB regulated by dopamine signaling mediates sleep-wakefulness.

No-Bridge of Drosophila Melanogaster: Portrait of a Structural Brain Mutant of the Central Complex

1992 ◽  
Vol 8 (3) ◽  
pp. 125-155 ◽  
Author(s):  
Roland Strauss ◽  
Ulrike Hanesch ◽  
Martin Kinkelin ◽  
Reinhard Wolf ◽  
Martin Heisenberg
Keyword(s):  
Drosophila Melanogaster ◽  
Central Complex ◽  
Structural Brain

scholarly journals Neuronal control of locomotor handedness in Drosophila

2014 ◽  
Author(s):  
Sean M Buchanan ◽  
Jamey S Kain ◽  
Benjamin L de Bivort
Keyword(s):  
Drosophila Melanogaster ◽  
Choice Behavior ◽  
Model Organism ◽  
Model System ◽  
Central Complex ◽  
Hand Dominance ◽  
Walking Behavior ◽  
General Body ◽  
Left Handed ◽  
Neuronal Control

Handedness in humans–better performance using either the left or right hand–is personally familiar, moderately heritable, and regulated by many genes, including those involved in general body symmetry. But behavioral handedness, i.e. lateralization, is a multifaceted phenomenon. For example, people display clockwise or counter- clockwise biases in their walking behavior that is uncorrelated to their hand dominance, and lateralized behavioral biases have been shown in species as disparate as mice (paw usage), octopi (eye usage), and tortoises (side rolled on during righting). However, the mechanisms by which asymmetries are instilled in behavior are unknown, and a system for studying behavioral handedness in a genetically tractable model system is needed. Here we show that Drosophila melanogaster flies exhibit striking variability in their left-right choice behavior during locomotion. Very strongly biased "left-handed" and "right-handed" individuals are common in every line assayed. The handedness of an individual persists for its lifetime, but is not passed on to progeny, suggesting that mechanisms other than genetics determine individual handedness. We use the Drosophila transgenic toolkit to map a specific set of neurons within the central complex that regulates the strength of behavioral handedness within a line. These findings give insights into choice behaviors and laterality in a simple model organism, and demonstrate that individuals from isogenic populations reared under experimentally identical conditions nevertheless display idiosyncratic behaviors.

The interruptive effect of electric shock on odor response requires mushroom bodies in Drosophila melanogaster

2018 ◽  
Vol 18 (2) ◽  
pp. e12488
Author(s):  
W. Song ◽  
L. Zhao ◽  
Y. Tao ◽  
X. Guo ◽  
J. Jia ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Electric Shock ◽  
Mushroom Bodies

scholarly journals Protocerebral Bridge Neurons That Regulate Sleep in Drosophila melanogaster

2021 ◽  
Vol 15 ◽  
Author(s):  
Jun Tomita ◽  
Gosuke Ban ◽  
Yoshiaki S. Kato ◽  
Kazuhiko Kume
Keyword(s):  
Drosophila Melanogaster ◽  
Synaptic Contact ◽  
Brain Regions ◽  
Central Complex ◽  
Neuronal Circuit ◽  
Sleep Regulation ◽  
Protocerebral Bridge ◽  
Dopamine Signaling

The central complex is one of the major brain regions that control sleep in Drosophila. However, the circuitry details of sleep regulation have not been elucidated yet. Here, we show a novel sleep-regulating neuronal circuit in the protocerebral bridge (PB) of the central complex. Activation of the PB interneurons labeled by the R59E08-Gal4 and the PB columnar neurons with R52B10-Gal4 promoted sleep and wakefulness, respectively. A targeted GFP reconstitution across synaptic partners (t-GRASP) analysis demonstrated synaptic contact between these two groups of sleep-regulating PB neurons. Furthermore, we found that activation of a pair of dopaminergic (DA) neurons projecting to the PB (T1 DA neurons) decreased sleep. The wake-promoting T1 DA neurons and the sleep-promoting PB interneurons formed close associations. Dopamine 2-like receptor (Dop2R) knockdown in the sleep-promoting PB interneurons increased sleep. These results indicated that the neuronal circuit in the PB, regulated by dopamine signaling, mediates sleep-wakefulness.

Neuronal architecture of the central complex in Drosophila melanogaster

1989 ◽  
Vol 257 (2) ◽  
pp. 343-366 ◽  
Author(s):  
U. Hanesch ◽  
K. -F. Fischbach ◽  
M. Heisenberg
Keyword(s):  
Drosophila Melanogaster ◽  
Central Complex
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