Neuronal architecture of the central complex in Drosophila melanogaster

1989 ◽  
Vol 257 (2) ◽  
pp. 343-366 ◽  
Author(s):  
U. Hanesch ◽  
K. -F. Fischbach ◽  
M. Heisenberg
Keyword(s):  
Drosophila Melanogaster ◽  
Central Complex

scholarly journals Protocerebral bridge neurons that regulate sleep in Drosophila melanogaster

2020 ◽  
Author(s):  
Jun Tomita ◽  
Gosuke Ban ◽  
Yoshiaki S. Kato ◽  
Kazuhiko Kume
Keyword(s):  
Drosophila Melanogaster ◽  
Brain Regions ◽  
Central Complex ◽  
Neuronal Circuit ◽  
Sleep Regulation ◽  
Synaptic Contacts ◽  
Protocerebral Bridge ◽  
Dopamine Signaling

AbstractThe central complex is one of the major brain regions that control sleep in Drosophila, but the circuitry details of sleep regulation have yet to be elucidated. Here, we show a novel sleep-regulating neuronal circuit in the protocerebral bridge (PB) of the central complex. Activation of the PB interneurons labeled by the R59E08-Gal4 and the PB columnar neurons in the R52B10-Gal4 promoted sleep and wakefulness, respectively. A targeted GFP reconstitution across synaptic partners (t-GRASP) analysis demonstrated synaptic contacts between these two groups of sleep-regulating PB neurons. Furthermore, we found that activation of a pair of dopaminergic (DA) neurons projecting to the PB (T1 DA neurons) decreased sleep. The wake-promoting T1 DA neurons and the sleep-promoting PB interneurons formed close associations. Dopamine 2-like receptor (Dop2R) knockdown in the sleep-promoting PB interneurons increased sleep. These results indicated that the neuronal circuit in the PB regulated by dopamine signaling mediates sleep-wakefulness.

No-Bridge of Drosophila Melanogaster: Portrait of a Structural Brain Mutant of the Central Complex

1992 ◽  
Vol 8 (3) ◽  
pp. 125-155 ◽  
Author(s):  
Roland Strauss ◽  
Ulrike Hanesch ◽  
Martin Kinkelin ◽  
Reinhard Wolf ◽  
Martin Heisenberg
Keyword(s):  
Drosophila Melanogaster ◽  
Central Complex ◽  
Structural Brain

scholarly journals Neuronal control of locomotor handedness in Drosophila

2014 ◽  
Author(s):  
Sean M Buchanan ◽  
Jamey S Kain ◽  
Benjamin L de Bivort
Keyword(s):  
Drosophila Melanogaster ◽  
Choice Behavior ◽  
Model Organism ◽  
Model System ◽  
Central Complex ◽  
Hand Dominance ◽  
Walking Behavior ◽  
General Body ◽  
Left Handed ◽  
Neuronal Control

Handedness in humans–better performance using either the left or right hand–is personally familiar, moderately heritable, and regulated by many genes, including those involved in general body symmetry. But behavioral handedness, i.e. lateralization, is a multifaceted phenomenon. For example, people display clockwise or counter- clockwise biases in their walking behavior that is uncorrelated to their hand dominance, and lateralized behavioral biases have been shown in species as disparate as mice (paw usage), octopi (eye usage), and tortoises (side rolled on during righting). However, the mechanisms by which asymmetries are instilled in behavior are unknown, and a system for studying behavioral handedness in a genetically tractable model system is needed. Here we show that Drosophila melanogaster flies exhibit striking variability in their left-right choice behavior during locomotion. Very strongly biased "left-handed" and "right-handed" individuals are common in every line assayed. The handedness of an individual persists for its lifetime, but is not passed on to progeny, suggesting that mechanisms other than genetics determine individual handedness. We use the Drosophila transgenic toolkit to map a specific set of neurons within the central complex that regulates the strength of behavioral handedness within a line. These findings give insights into choice behaviors and laterality in a simple model organism, and demonstrate that individuals from isogenic populations reared under experimentally identical conditions nevertheless display idiosyncratic behaviors.

scholarly journals Protocerebral Bridge Neurons That Regulate Sleep in Drosophila melanogaster

2021 ◽  
Vol 15 ◽  
Author(s):  
Jun Tomita ◽  
Gosuke Ban ◽  
Yoshiaki S. Kato ◽  
Kazuhiko Kume
Keyword(s):  
Drosophila Melanogaster ◽  
Synaptic Contact ◽  
Brain Regions ◽  
Central Complex ◽  
Neuronal Circuit ◽  
Sleep Regulation ◽  
Protocerebral Bridge ◽  
Dopamine Signaling

The central complex is one of the major brain regions that control sleep in Drosophila. However, the circuitry details of sleep regulation have not been elucidated yet. Here, we show a novel sleep-regulating neuronal circuit in the protocerebral bridge (PB) of the central complex. Activation of the PB interneurons labeled by the R59E08-Gal4 and the PB columnar neurons with R52B10-Gal4 promoted sleep and wakefulness, respectively. A targeted GFP reconstitution across synaptic partners (t-GRASP) analysis demonstrated synaptic contact between these two groups of sleep-regulating PB neurons. Furthermore, we found that activation of a pair of dopaminergic (DA) neurons projecting to the PB (T1 DA neurons) decreased sleep. The wake-promoting T1 DA neurons and the sleep-promoting PB interneurons formed close associations. Dopamine 2-like receptor (Dop2R) knockdown in the sleep-promoting PB interneurons increased sleep. These results indicated that the neuronal circuit in the PB, regulated by dopamine signaling, mediates sleep-wakefulness.

scholarly journals Neuronal control of locomotor handedness in Drosophila

2015 ◽  
Vol 112 (21) ◽  
pp. 6700-6705 ◽  
Author(s):  
Sean M. Buchanan ◽  
Jamey S. Kain ◽  
Benjamin L. de Bivort
Keyword(s):  
Drosophila Melanogaster ◽  
Exploratory Behavior ◽  
Motor Planning ◽  
Central Complex ◽  
Leg Length ◽  
Neuronal Control ◽  
Significant Bias ◽  
Locomotor Behaviors ◽  
The Brain ◽  
Wing Folding

Genetically identical individuals display variability in their physiology, morphology, and behaviors, even when reared in essentially identical environments, but there is little mechanistic understanding of the basis of such variation. Here, we investigated whether Drosophila melanogaster displays individual-to-individual variation in locomotor behaviors. We developed a new high-throughout platform capable of measuring the exploratory behavior of hundreds of individual flies simultaneously. With this approach, we find that, during exploratory walking, individual flies exhibit significant bias in their left vs. right locomotor choices, with some flies being strongly left biased or right biased. This idiosyncrasy was present in all genotypes examined, including wild-derived populations and inbred isogenic laboratory strains. The biases of individual flies persist for their lifetime and are nonheritable: i.e., mating two left-biased individuals does not yield left-biased progeny. This locomotor handedness is uncorrelated with other asymmetries, such as the handedness of gut twisting, leg-length asymmetry, and wing-folding preference. Using transgenics and mutants, we find that the magnitude of locomotor handedness is under the control of columnar neurons within the central complex, a brain region implicated in motor planning and execution. When these neurons are silenced, exploratory laterality increases, with more extreme leftiness and rightiness. This observation intriguingly implies that the brain may be able to dynamically regulate behavioral individuality.

Étude de l'inhibition sexuelle acquise chez un mutant neurologique, no-bridgeKS49, appartenant à l'espèce Drosophila melanogaster

1994 ◽  
Vol 72 (8) ◽  
pp. 1376-1382
Author(s):  
A. Bouhouche ◽  
M. K. Choulli
Keyword(s):  
Drosophila Melanogaster ◽  
Conditioned Inhibition ◽  
Motor Behavior ◽  
Behavior Pattern ◽  
Central Complex ◽  
Wild Type ◽  
Descending Inhibition ◽  
Brain Hemispheres ◽  
Sequential Organization ◽  
Brain Center

The conditioned inhibition of courtship in male was quantitatively and sequentially studied in the Drosophila melanogaster neurological mutant no-bridgeKS49 (nob). After being paired first with a previously fertilized (unreceptive) female, wild-type Berlin males court virgin, receptive females less vigorously (if not at all) then naive wild-type males do. This conditioned inhibition is characterized by the latency of the first contact, the frequency and duration of the courtship acts, and the sequential organization of the kinetograph. In contrast, when presented with the same sequence, the nob males were not inhibited, as reflected in all courtship parameters; their courtship performance with virgin females was similar to that of naive nob males. This behavior pattern could be due to the disorganization of their protocerebral bridge interrupting inhibitory interactions between the two brain hemispheres, thereby causing uncoordinated descending inhibition of the motor behavior. The results suggest that the central complex could be the high brain center controlling this kind of learning.

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