scholarly journals A one-step biofunctionalization strategy of electrospun scaffolds enables spatially selective presentation of biological cues

2019 ◽  
Author(s):  
Paul Wieringa ◽  
Andre Girao ◽  
Roman Truckenmuller ◽  
Alexander Welle ◽  
Silvestro Micera ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Regenerative Medicine ◽  
Dorsal Root ◽  
Neurite Growth ◽  
Electrospun Scaffolds ◽  
Selective Functionalization ◽  
Promising Strategy ◽  
Reactive Groups ◽  
Spatial Domains ◽  
One Step

AbstractTo recapitulate the heterogeneous complexity of tissues in our body with synthetic mimics of the extracellular matrix (ECM), it is important to develop methods that can easily allow the selective functionalization of defined spatial domains. Here, we introduce a facile method to functionalize microfibrillar meshes with different reactive groups able to bind biological moieties in a one-step reaction. The resulting scaffolds proved to selectively support a differential neurite growth after being seeded with dorsal root ganglia. Considering the general principles behind the method developed, this is a promising strategy to realize enhanced biomimicry of native ECM for different regenerative medicine applications.

scholarly journals A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

2017 ◽  
Vol 2 (1) ◽  
pp. 46-61 ◽  
Author(s):  
Kevin P. Feltz ◽  
Emily A. Growney Kalaf ◽  
Chengpeng Chen ◽  
R. Scott Martin ◽  
Scott A. Sell
Keyword(s):  
Magnetic Field ◽  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Regenerative Medicine ◽  
Electrospinning Process ◽  
Electrospun Scaffolds ◽  
Alternative Techniques ◽  
Fiber Deposition ◽  
Medicine Community ◽  
Field Manipulation

Abstract Electrospinning has been widely accepted for several decades by the tissue engineering and regenerative medicine community as a technique for nanofiber production. Owing to the inherent flexibility of the electrospinning process, a number of techniques can be easily implemented to control fiber deposition (i.e. electric/ magnetic field manipulation, use of alternating current, or air-based fiber focusing) and/or porosity (i.e. air impedance, sacrificial porogen/sacrificial fiber incorporation, cryo-electrospinning, or alternative techniques). The purpose of this review is to highlight some of the recent work using these techniques to create electrospun scaffolds appropriate for mimicking the structure of the native extracellular matrix, and to enhance the applicability of advanced electrospinning techniques in the field of tissue engineering.

scholarly journals Porous scaffolds with the structure of an interpenetrating polymer network made by gelatin methacrylated nanoparticle-stabilized high internal phase emulsion polymerization targeted for tissue engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (37) ◽  
pp. 22544-22555
Author(s):  
Atefeh Safaei-Yaraziz ◽  
Shiva Akbari-Birgani ◽  
Nasser Nikfarjam
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Cell Growth ◽  
Polymer Network ◽  
Synthetic Polymers ◽  
Tissue Scaffolds ◽  
Interpenetrating Polymer Network ◽  
Porous Scaffolds ◽  
Promising Strategy ◽  
Internal Phase

The interlacing of biopolymers and synthetic polymers is a promising strategy to fabricate hydrogel-based tissue scaffolds to biomimic a natural extracellular matrix for cell growth.

scholarly journals Special Issue: Application of Extracellular Matrix in Regenerative Medicine

2021 ◽  
Vol 11 (7) ◽  
pp. 3262
Author(s):  
Neill J. Turner
Keyword(s):  
Extracellular Matrix ◽  
Regenerative Medicine ◽  
Wound Repair ◽  
Three Dimensional ◽  
Dynamic Structure ◽  
Scaffold Material ◽  
Special Issue ◽  
Organ Regeneration ◽  
Scaffold Materials ◽  
The Many

The present Special Issue comprises a collection of articles addressing the many ways in which extracellular matrix (ECM), or its components parts, can be used in regenerative medicine applications. ECM is a dynamic structure, composed of a three-dimensional architecture of fibrous proteins, proteoglycans, and glycosaminoglycans, synthesized by the resident cells. Consequently, ECM can be considered as nature’s ideal biologic scaffold material. The articles in this Special Issue cover a range of topics from the use of ECM components to manufacture scaffold materials, understanding how changes in ECM composition can lead to the development of disease, and how decellularization techniques can be used to develop tissue-derived ECM scaffolds for whole organ regeneration and wound repair. This editorial briefly summarizes the most interesting aspects of these articles.

scholarly journals Methionine epimerization in cyclic peptides

RSC Advances ◽  
2021 ◽  
Vol 11 (34) ◽  
pp. 20859-20864
Author(s):  
Pramodkumar D. Jadhav ◽  
Jianheng Shen ◽  
Peta-Gaye Burnett ◽  
Jian Yang ◽  
Ramaswami Sammynaiken ◽  
...  
Keyword(s):  
Cyclic Peptides ◽  
Selective Functionalization ◽  
One Step

One step regioselective methionine epimerization in cyclic peptides followed by selective functionalization leads to chemical novelty.

scholarly journals Development of novel apoptosis-assisted lung tissue decellularization methods

2021 ◽  
Author(s):  
Young Hye Song ◽  
Mark Maynes ◽  
Nora Hlavac ◽  
Daniel Visosevic ◽  
Kaitlyn Daramola ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Regenerative Medicine ◽  
Lung Tissue ◽  
Disease Modeling

Decellularized tissues hold great potential for both regenerative medicine and disease modeling applications. The acellular extracellular matrix (ECM)-enriched scaffolds can be recellularized with patient-derived cells prior to transplantation, or digested...

scholarly journals Harnessing the Topography of 3D Spongy-Like Electrospun Bundled Fibrous Scaffold via a Sharply Inclined Array Collector

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1444 ◽  
Author(s):  
Sun Hee Cho ◽  
Jeong In Kim ◽  
Cheol Sang Kim ◽  
Chan Hee Park ◽  
In Gi Kim
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Three Dimensional ◽  
Living System ◽  
Pivotal Role ◽  
Skin Tissue ◽  
Target Tissue ◽  
Fibrous Scaffold ◽  
Electrospun Scaffolds ◽  
Directional Change

To date, many researchers have studied a considerable number of three-dimensional (3D) cotton-like electrospun scaffolds for tissue engineering, including the generation of bone, cartilage, and skin tissue. Although numerous 3D electrospun fibrous matrixes have been successfully developed, additional research is needed to produce 3D patterned and sophisticated structures. The development of 3D fibrous matrixes with patterned and sophisticated structures (FM-PSS) capable of mimicking the extracellular matrix (ECM) is important for advancing tissue engineering. Because modulating nano to microscale features of the 3D fibrous scaffold to control the ambient microenvironment of target tissue cells can play a pivotal role in inducing tissue morphogenesis after transplantation in a living system. To achieve this objective, the 3D FM-PSSs were successfully generated by the electrospinning using a directional change of the sharply inclined array collector. The 3D FM-PSSs overcome the current limitations of conventional electrospun cotton-type 3D matrixes of random fibers.

scholarly journals Cyclic Strain Affects Macrophage Cytokine Secretion and Extracellular Matrix Turnover in Electrospun Scaffolds

2019 ◽  
Vol 25 (17-18) ◽  
pp. 1310-1325 ◽  
Author(s):  
Valentina Bonito ◽  
Bente J. de Kort ◽  
Carlijn V.C. Bouten ◽  
Anthal I.P.M. Smits
Keyword(s):  
Extracellular Matrix ◽  
Cyclic Strain ◽  
Cytokine Secretion ◽  
Electrospun Scaffolds ◽  
Macrophage Cytokine

Random and aligned PLLA : PRGF electrospun scaffolds for regenerative medicine

2014 ◽  
Vol 132 (5) ◽  
pp. n/a-n/a ◽  
Author(s):  
Luis Díaz-Gómez ◽  
Florencia Montini Ballarin ◽  
Gustavo A. Abraham ◽  
Angel Concheiro ◽  
Carmen Alvarez-Lorenzo
Keyword(s):  
Regenerative Medicine ◽  
Electrospun Scaffolds
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