scholarly journals Differential effects of opioid receptor modulators on motivational and stress-coping behaviors in the back-translational rat IFN-α depression model

2019 ◽  
Author(s):  
Charlotte K. Callaghan ◽  
Jennifer Rouine ◽  
Md Nurul Islam ◽  
David J. Eyerman ◽  
Karen L. Smith ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Partial Agonist ◽  
Forced Swim Test ◽  
Antidepressant Drug ◽  
Coping Behavior ◽  
Progressive Ratio ◽  
Hippocampal Neurogenesis ◽  
Stress Coping ◽  
Coping Behaviors ◽  
Assay Sensitivity

AbstractRationaleMany patients respond inadequately to antidepressant drug treatment; the search for alternate pharmacological treatment mechanisms is ongoing. Until the 1950’s, opium was sometimes used to treat depression, but eventually abandoned due to addiction risk. Recent insights into opioid biology have sparked a renewed interest in the potential antidepressant properties of opioids.ObjectiveWe studied how mu (MOR), kappa (KOR) and delta (DOR) opioid receptor ligands affect the dysregulation of motivated behavior (progressive ratio responding; PR), stress-coping behavior (forced swim test; FST) and hippocampal neurogenesis in rats, all induced by the back-translational interferon-alpha (IFN-α)-induced depression model.MethodsMale Wistar rats (3-months old, 8/group) were treated with recombinant human IFN-α (170,000 IU/kg, 3 times/week) or saline. Ligands of the MOR, KOR and DOR receptors were administered as follows: a single subcutaneous dose, 30min before PR and 1h before FST, of the MOR agonist morphine (full agonist; 5mg/kg), the partial agonist RDC 2944 (0.1mg/kg) and the antagonist, cyprodime (10mg/kg); of the KOR agonist, U50 488 (5mg/kg), the antagonist, DIPPA (10mg/kg); and the DOR agonist, SNC 80 (20mg/kg) and antagonist naltrindole (10mg/kg). After 4 days of treatment with the mitotic BrdU marker, hippocampi were harvested and analysed for neurogenesis. Fluoxetine (10 mg/kg/day for 4 weeks, orally) served as control for assay sensitivity in the FST.ResultsThe KOR antagonist, DIPPA, the DOR agonist SNC 80 and fluoxetine reversed the IFN-α-induced immobility increase in the FST. The MOR agonist, morphine, the KOR antagonist DIPPA, and the KOR agonist U50 488 reduced the IFN-α-induced increase in the breakpoint in the PR. The DOR agonist SNC 80 recovered the IFN-α-induced decrease in BrdU+ hippocampal cells.ConclusionOpioid receptors mediate different aspects of the IFN-α-induced dysregulation of motivational and stress-coping behaviors and hippocampal neurogenesis in a back-translational model of depression. KORs and DORs appear to play more prominent roles in torpor–inertia-type behaviors, whereas DORs appear more involved in the regulation of neurogenesis.

scholarly journals Mastication as a Stress-Coping Behavior

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Kin-ya Kubo ◽  
Mitsuo Iinuma ◽  
Huayue Chen
Keyword(s):  
Nervous System ◽  
Coping Behavior ◽  
Plasma Corticosterone ◽  
Ulcer Formation ◽  
Stress Coping ◽  
Coping Behaviors ◽  
Coping With Stress ◽  
Related Substances ◽  
Neuronal Mechanisms ◽  
Induced Changes

Exposure to chronic stress induces various physical and mental effects that may ultimately lead to disease. Stress-related disease has become a global health problem. Mastication (chewing) is an effective behavior for coping with stress, likely due to the alterations chewing causes in the activity of the hypothalamic-pituitary-adrenal axis and autonomic nervous system. Mastication under stressful conditions attenuates stress-induced increases in plasma corticosterone and catecholamines, as well as the expression of stress-related substances, such as neurotrophic factors and nitric oxide. Further, chewing reduces stress-induced changes in central nervous system morphology, especially in the hippocampus and hypothalamus. In rodents, chewing or biting on wooden sticks during exposure to various stressors reduces stress-induced gastric ulcer formation and attenuates spatial cognitive dysfunction, anxiety-like behavior, and bone loss. In humans, some studies demonstrate that chewing gum during exposure to stress decreases plasma and salivary cortisol levels and reduces mental stress, although other studies report no such effect. Here, we discuss the neuronal mechanisms that underline the interactions between masticatory function and stress-coping behaviors in animals and humans.

scholarly journals Psychometric Properties of Behavioral Checklist for Coping with Stress in Patients with Mood Disorders

2021 ◽  
Vol 18 (2) ◽  
pp. 147-156
Author(s):  
Hyun Ju Lim ◽  
Eunsoo Moon ◽  
Hwagyu Suh ◽  
Sun Kyeong Yang ◽  
Je Min Park ◽  
...  
Keyword(s):  
Psychometric Properties ◽  
Depressive Disorders ◽  
Common Factor ◽  
Coping Behavior ◽  
Reliability And Validity ◽  
Principal Component ◽  
Stress Coping ◽  
Coping Behaviors ◽  
Coping With Stress ◽  
Behavioral Checklist

Objective Even though the importance of stress-coping, there is no reliable and valid scale to measure the stress-coping behavior yet. The purpose of this study is to explore the psychometric properties of Behavioral Checklist for Coping with Stress (BCCS).Methods A total of 458 subjects including healthy subjects and patients with bipolar or depressive disorders were analyzed. The reliability and validity of BCCS were examined by Chronbach’s alpha and exploratory factor analysis using Principal Component Analysis. In order to evaluate criterion-related validity, the Pearson’s correlation analyses between factors of BCCS and relevant scales were performed.Results BCCS showed good Chronobach’s alpha (0.695–0.833) and had acceptable validity. Factor 1 and factor 4 of BCCS were negatively correlated with depression, anxiety and positivity correlated with task and problem-solving, avoidance, tension-releasing copings in common. Factor 2 and 3 were positively correlated with impulsivity, emotionality, avoidance, behavioral and verbal aggression and tension-releasing copings in common. Different from factor 2, factor 3 was positively correlated with depression, anxiety and anger-suppression.Conclusion The results of this study suggest that this BCCS might be a reliable and valid scale for measuring stress-coping behaviors. This scale could facilitate research to investigate clinical implications related to behavioral stress-coping.

VULNERABILITY TO FLOODING AND COPING BEHAVIOR FOUND IN HOUSING CONDITION: A CASE STUDY IN VAN QUAT DONG VILLAGE, TAM GIANG LAGOON AREA, CENTRAL VIETNAM

2017 ◽  
Vol 126 (4B) ◽  
pp. 49
Author(s):  
Trần Thanh Đức
Keyword(s):  
Natural Disasters ◽  
Coping Behavior ◽  
Housing Condition ◽  
Local People ◽  
Coping Behaviors ◽  
Poverty Level ◽  
Livelihood Security ◽  
Central Vietnam ◽  
And Coping ◽  
The Village

<p>Vietnam is a country that is suffered from frequent natural disasters. The most common types of natural disasters experienced are typhoon and flood. From 1951 to 2010, there were 166 typhoons come to Vietnam, of which 67 % hit the central region, 25 % to the north and 8 % to the south of the country. Typhoons bring heavy rains and high tides which accelerate floods, particularly in the coastal and lagoon areas of Central Vietnam. Identification of vulnerability to flooding and coping behavior of local people is required in the efforts to strengthen local capacity related to livelihood security in the study area. This study aims at characterizing the vulnerability of housing condition to flooding and the coping behaviors of local people after experienced big floods in Tam Giang lagoon area, Central Vietnam. Measurement of house’s foundation, observation of types of housing, interview to collect information about the water level during the events of big floods, year of construction and change of people’s behavior after the 1999’s flood were conducted with 427 households in Van Quat Dong village where four big flooding occurred in 1983, 1999, 2007 and 2009 during the last 30 years. The study shows that the 1999’s flood was the biggest flood with water height reached to 148.7 ± 23.9 cmfrom house floor and 222.6 ± 15.4 cmfrom ground level. The households located in the eastern part of the village are recognized more vulnerable to flood due to the lower altitude. The temporary and semi-permanent houses, which share 77.0 % to the entire houses, are considered to be relatively vulnerable to flooding due to weak housing materials and low height of foundation. The houses which categorized to permanent and semi-permanent types constructed after the 1999’s flood have higher foundation than the other houses constructed before the 1999’s flood. The raising of foundation height of permanent and semi-permanent houses, as well as an increase in numbers of two-storey houses, are recognized to be a behavior of local people to cope with flooding. The study also shows the relationship between the poverty level and the coping behaviors of households. Some of poor households in the village are still not in good preparedness to flooding. It suggests that poverty level of household concerns to the vulnerability to flooding and, therefore, rural development assistance to improve household economy for poverty alleviation is required in the efforts to strengthen local capacity related to livelihood security.<strong></strong></p>

scholarly journals Risk Perception and Coping Behavior of Construction Workers on Occupational Health Risks—A Case Study of Nanjing, China

2021 ◽  
Vol 18 (13) ◽  
pp. 7040
Author(s):  
Hui Liu ◽  
Jie Li ◽  
Hongyang Li ◽  
He Li ◽  
Peng Mao ◽  
...  
Keyword(s):  
Risk Perception ◽  
Occupational Health ◽  
Health Risks ◽  
Coping Behavior ◽  
Education Level ◽  
Construction Workers ◽  
Personal Knowledge ◽  
Coping Behaviors ◽  
And Coping ◽  
Health Risk Perception

To reduce harm caused by occupational health risks of construction workers exposed to working environments, especially those for interior decoration, it is crucial for them to actively recognize and prevent these risks. Therefore, how to improve their occupational health risks perception and regulate their coping behaviors should be of great concern. However, most prior studies target construction worker safety, and little research focuses on risk analysis from the psychological level of workers. Hence, construction workers’ occupational health risk perception level and coping behavior level in Nanjing and the influencing factors were analyzed through statistical analysis with 341 valid questionnaires. Bootstrapping was applied to test the mediating effects of risk perception on the proposed factors and coping behaviors. This study revealed that construction workers have a high-level of occupational health risk perception, yet low-level coping behavior. Gender, age, education level, and unit qualification cause differences in individual risk perception level. Personal knowledge and group effects significantly affect the level of risk perception, which subsequently affect coping behavior. Education level, monthly income, and personal knowledge influence the coping behavior through risk perception. Recommendations were put forward for risk perception and coping behavior improvement from the perspectives of construction workers themselves, enterprises, and governments. This study sheds new light for research areas of occupational health and risk management and provides beneficial practice for improving construction workers’ responses to occupational health risks.

scholarly journals Loss of mGluR5 in D1 Receptor-Expressing Neurons Improves Stress Coping

2021 ◽  
Vol 22 (15) ◽  
pp. 7826
Author(s):  
Luca Zangrandi ◽  
Claudia Schmuckermair ◽  
Hussein Ghareh ◽  
Federico Castaldi ◽  
Regine Heilbronn ◽  
...  
Keyword(s):  
Stress Responses ◽  
Metabotropic Glutamate Receptor ◽  
Forced Swim Test ◽  
Functional Integration ◽  
D1 Receptor ◽  
Conditional Knockout ◽  
Stress Coping ◽  
Metabotropic Glutamate ◽  
Internal States

The metabotropic glutamate receptor type 5 (mGluR5) has been proposed to play a crucial role in the selection and regulation of cognitive, affective, and emotional behaviors. However, the mechanisms by which these receptors mediate these effects remain largely unexplored. Here, we studied the role of mGluR5 located in D1 receptor-expressing (D1) neurons in the manifestation of different behavioral expressions. Mice with conditional knockout (cKO) of mGluR5 in D1 neurons (mGluR5D1 cKO) and littermate controls displayed similar phenotypical profiles in relation to memory expression, anxiety, and social behaviors. However, mGluR5D1 cKO mice presented different coping mechanisms in response to acute escapable or inescapable stress. mGluR5D1 cKO mice adopted an enhanced active stress coping strategy upon exposure to escapable stress in the two-way active avoidance (TWA) task and a greater passive strategy upon exposure to inescapable stress in the forced swim test (FST). In summary, this work provides evidence for a functional integration of the dopaminergic and glutamatergic system to mediate control over internal states upon stress exposure and directly implicates D1 neurons and mGluR5 as crucial mediators of behavioral stress responses.

scholarly journals Prefrontal/Amygdalar System Determines Stress Coping Behavior Through 5-HT/GABA Connection

2013 ◽  
Vol 38 (10) ◽  
pp. 2057-2067 ◽  
Author(s):  
Diego Andolina ◽  
Dario Maran ◽  
Alessandro Valzania ◽  
David Conversi ◽  
Stefano Puglisi-Allegra
Keyword(s):  
Coping Behavior ◽  
Stress Coping

scholarly journals A stress-coping model of mental illness stigma: II. Emotional stress responses, coping behavior and outcome

2009 ◽  
Vol 110 (1-3) ◽  
pp. 65-71 ◽  
Author(s):  
Nicolas Rüsch ◽  
Patrick W. Corrigan ◽  
Karina Powell ◽  
Anita Rajah ◽  
Manfred Olschewski ◽  
...  
Keyword(s):  
Mental Illness ◽  
Emotional Stress ◽  
Stress Responses ◽  
Coping Behavior ◽  
Mental Illness Stigma ◽  
Stress Coping ◽  
Coping Model

scholarly journals Glucoregulation and coping behavior after chronic stress: sex differences across the lifespan

2021 ◽  
Author(s):  
Carley Dearing ◽  
Rachel Morano ◽  
Elaine Ptaskiewicz ◽  
Parinaz Mahbod ◽  
Jessie R Scheimann ◽  
...  
Keyword(s):  
Sex Differences ◽  
Chronic Stress ◽  
Life Stress ◽  
Forced Swim Test ◽  
Coping Behavior ◽  
Early Life Stress ◽  
Tolerance Test ◽  
Sprague Dawley ◽  
Late Adolescent ◽  
Passive Coping

AbstractExposure to prolonged stress during adolescence taxes adaptive and homeostatic processes leading to deleterious behavioral and metabolic outcomes. Although previous pre-clinical studies found effects of early life stress on cognition and stress hormone reactivity, these studies largely focused on males. The purpose of the current study was to determine how biological sex shapes behavioral coping and metabolic health across the lifespan after chronic stress. We hypothesized that examining chronic stress-induced behavioral and endocrine outcomes would reveal sex differences in the biological basis of susceptibility. During the late adolescent period, male and female Sprague-Dawley rats experienced chronic variable stress (CVS). Following completion of CVS, all rats experienced a forced swim test (FST) followed 3 days later by a fasted glucose tolerance test (GTT). The FST was used to determine coping in response to a stressor. Endocrine metabolic function was evaluated in the GTT by measuring glucose and corticosterone, the primary rodent glucocorticoid. Animals then aged to 15 months when the FST and GTT were repeated. In young animals, chronically stressed females exhibited more passive coping and corticosterone release in the FST. Additionally, chronically stressed females had elevated corticosterone and impaired glucose clearance in the GTT. Aging affected all measurements as behavioral and endocrine outcomes were sex specific. Furthermore, regression analysis between hormonal and behavioral responses identified associations depending on sex and stress. Collectively, these data indicate female susceptibility to the effects of chronic stress during adolescence. Further, translational investigation of coping style and glucose homeostasis may identify biomarkers for stress-related disorders.

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