scholarly journals Implantable electrical stimulation bioreactor with liquid crystal polymer based electrodes for enhanced bone regeneration at mandibular large defects in rabbit

2018 ◽  
Author(s):  
Chaebin Kim ◽  
Hoon Joo Yang ◽  
Tae Hyung Cho ◽  
Beom Seok Lee ◽  
Tae Mok Gwon ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Liquid Crystal ◽  
Bone Regeneration ◽  
Bone Defects ◽  
Control Group ◽  
Sham Control ◽  
Crystal Polymer ◽  
Sham Control Group ◽  
Large Bone ◽  
Large Bone Defects

AbstractThe osseous regeneration of large bone defects is still a major clinical challenge in maxillofacial and orthopedic surgery. Our previous studies demonstrated that electrical stimulation (ES) with biphasic current pulse showed proliferative effects on bone cells and enhanced secretion of bone-forming growth factors. This study presents an implantable electrical stimulation bioreactor with electrodes based on liquid crystal polymer (LCP), which has excellent bone-binding property. The bioreactor was implanted into a critical sized bone defect and subjected to ES for one week, where bone regeneration was evaluated four weeks after surgery using micro-CT. The effect of ES via bioreactor was compared with a sham control group and positive control group that received recombinant human bone morphogenetic protein (rhBMP)-2 (20 μg). New bone volume per tissue volume (BV/TV) in the ES and rhBMP-2 groups increased to 171% (p< 0.001) and 210% (p < 0.001), respectively, compared to that in the sham control group. In the histological evaluation, there was no inflammation within bone defects and adjacent to LCP in all groups. This study showed that the ES bioreactor with LCP electrodes could enhance bone regeneration at large bone defects, where LCP can act as a mechanically resistant outer box without inflammation.

scholarly journals Treatment possibilities of jaws bone defects: A case report

2010 ◽  
Vol 57 (1) ◽  
pp. 49-53
Author(s):  
Nenad Tanaskovic ◽  
Sinisa Ristic ◽  
Miroslav Lucic
Keyword(s):  
Bone Regeneration ◽  
Bone Destruction ◽  
Bone Defects ◽  
Significant Loss ◽  
Bone Augmentation ◽  
Surrounding Soft Tissue ◽  
Prosthetic Reconstruction ◽  
Previous Trauma ◽  
Large Bone ◽  
Large Bone Defects

Large bone defects in the jaws can occur as a result of previous trauma, tumor or bone destruction caused by infection. Significant loss of bone volume also may be caused by premature loss of teeth, application of inadequate extraction technique, periodontitis or trauma caused by incorrect prosthetic reconstruction. Very few of these defects are treated using materials for bone augmentation or regeneration in order to preserve the total volume of bone. Depending on the size of a defect, spontaneous bone regeneration of untreated defects is limited by proliferation of surrounding soft tissue. Bone replacement by connective tissue leads to loss of stability, reduces function and disturbs anatomical form of the jaws. The aim of the study was to present a case from clinical praxis which demonstrates bone regeneration provided by bone substitute or its combination with bone grafts.

scholarly journals Femoral bone defect healing using two novel biocompatible degradable materials

2020 ◽  
Vol 89 (2) ◽  
pp. 163-169
Author(s):  
Robert Srnec ◽  
Andrea Nečasová ◽  
Pavel Proks ◽  
Miša Škorič ◽  
Zita Filipejová ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Marrow Cells ◽  
Plate Osteosynthesis ◽  
Bone Defects ◽  
Femoral Diaphysis ◽  
Control Group ◽  
Histological Assessment ◽  
Bone Defect Healing ◽  
Large Bone ◽  
Large Bone Defects

This study was conducted as an in vivo experiment in adult miniature pigs with the aim to test two new biomaterials. An iatrogenic defect was made into the central femoral diaphysis in the experimental animals and subsequently fixated by bridging plate osteosynthesis. Into the defect we implanted a cancellous autograft (control group), a pasty injectable scaffold (EXP A), and a porous 3D cylinder (EXP B). Radiological examination was performed in all animals at 0, 10, 20, 30 weeks after surgical procedure and histological assessment was performed. In the newly formed bone the osteoblastic activity was monitored. In terms of radiology, the most effective method was observed in the control group (completely healed 100%) compared to experimental groups EXP A (70.0%) and EXP B (62.5%). Histological assessment showed a higher cell count in the place of bone defect in the control group compared to experimental groups. Between the experimental groups, a higher count of bone marrow cells was found in group EXP B. Both newly developed biomaterials seem to be suitable as replacements for large bone defects, having good workability and applicability. However, compared to the control group treated with a cancellous autograft, the newly formed bone did not reach the same number of cells settling in and in some cases, full radiological healing was not reached. Nevertheless, the material was found to be grown into the original bone in all cases within the experimental groups. The new biomaterials have a great potential as a substitute in the treatment of large bone defects.

Strontium-calcium phosphate hybrid cement with enhanced osteogenic and angiogenic properties for vascularised bone regeneration

2021 ◽  
Author(s):  
Xiexing Wu ◽  
Ziniu Tang ◽  
Kang Wu ◽  
Yanjie Bai ◽  
X. LIN ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Calcium Phosphate Cement ◽  
Treatment Options ◽  
Bone Defects ◽  
Large Bone ◽  
Large Bone Defects ◽  
Vascularized Bone

Vascularized bone tissue engineering is regarded as one of the optimal treatment options for large bone defects. The lack of angiogenic property and unsatisfactory physicochemical performance restricts calcium phosphate cement...

Application of structural allogenous bone graft in two-stage exchange arthroplasty for knee periprosthetic joint infection: a case control study

2021 ◽  
Author(s):  
ChiehAn Chuang ◽  
Sheng-Hsun Lee ◽  
Chih-Hsiang Chang ◽  
Chih-Chien Hu ◽  
Hsin-Nung Shih ◽  
...  
Keyword(s):  
Survival Rate ◽  
Bone Graft ◽  
Joint Infection ◽  
Bone Defects ◽  
Control Group ◽  
Study Group ◽  
Free Survival ◽  
Fresh Frozen ◽  
Large Bone ◽  
Large Bone Defects

Abstract Background: Knee prosthetic joint infection (PJI) is a common but devastating complication after knee arthroplasty. The revision surgeries for knee PJI may become more challenging when it is associated with large bone defects. The application of structural bone allograft in knee revision surgeries with large bone defects is not a new technique. However, there is a lack of literature reporting its efficacy in PJI cases. This study aimed to investigate the outcome of structural fresh frozen allogenous bone grafts in treating patients in knee PJI with large bone defects. Methods: We performed a retrospective cohort analysis of knee PJI cases treated with two-stage exchange arthroplasty at our institution from 2010 to 2016. 12 patients with structural allogenous bone graft reconstructions were identified as the study group. 24 patients without structural allograft reconstructions matched with the study group by age, gender, and Charlson comorbidity index were enrolled as the control group. The functional outcome of the study group was evaluated with the Knee Society Score (KSS). Treatment success was assessed according to the Delphi-based consensus definition. The infection relapse rate and implant survivorship were compared between groups. Results: Revision knees with structural allograft presented excellent improvement in the KSS (33.1 to 75.4). There was no significant difference between infection relapse-free survival rate and prosthesis survival rate in two groups. The 8-year prosthesis survival rate was 90.9% in the study group and 91% in the control group (p = 0.913). The 8-year infection relapse-free survival rate was 80% and 83.3% in the study group and control group, respectively (p = 0.377). Conclusion: The structural fresh frozen allogenous bone graft provided an effective way for bone defect reconstruction in knee PJI with accountable survival rate. Meanwhile, using structural allografts did not increase the relapse rate of infection.

scholarly journals Combining electrical stimulation and tissue engineering to treat large bone defects in a rat model

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Liudmila Leppik ◽  
Han Zhihua ◽  
Sahba Mobini ◽  
Vishnu Thottakkattumana Parameswaran ◽  
Maria Eischen-Loges ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Electrical Stimulation ◽  
Rat Model ◽  
Bone Defects ◽  
Large Bone ◽  
Large Bone Defects

scholarly journals Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Bei Yin ◽  
Qingge Ma ◽  
Chenghao Song ◽  
Lingyi Zhao ◽  
Fanyuan Yu ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Noncoding Rnas ◽  
Bone Defects ◽  
Paracrine Factors ◽  
Bioactive Materials ◽  
Allogenic Bone ◽  
Promising Treatment ◽  
Large Bone ◽  
Great Focus ◽  
Large Bone Defects

The reconstruction of large bone defects remains a crucial challenge in orthopedic surgery. The current treatments including autologous and allogenic bone grafting and bioactive materials have their respective drawbacks. While mesenchymal stem cell (MSC) therapy may address these limitations, growing researches have demonstrated that the effectiveness of MSC therapy depends on paracrine factors, particularly exosomes. This aroused great focus on the exosome-based cell-free therapy in the treatment of bone defects. Exosomes can transfer various cargoes, and noncoding RNAs are the most widely studied cargo through which exosomes exert their ability of osteoinduction. Here, we review the research status of the exosome-derived noncoding RNAs in bone regeneration, the potential application of exosomes, and the existing challenges.

scholarly journals In vitroandin vivocharacterization of strontium-containing calcium sulfate/poly(amino acid) composite as a novel bioactive graft for bone regeneration

RSC Advances ◽  
2017 ◽  
Vol 7 (86) ◽  
pp. 54306-54312 ◽  
Author(s):  
Wu Jun ◽  
Wang Peng ◽  
Jiang Dianming ◽  
Li Hong ◽  
Luo Cong ◽  
...  
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Bone Regeneration ◽  
Calcium Sulfate ◽  
Bone Defects ◽  
Large Bone ◽  
Large Bone Defects

Doped strontium enhanced the biological activity of CS/PAA composites for repairing large bone defects.

3D-printed magnetic Fe3O4/MBG/PCL composite scaffolds with multifunctionality of bone regeneration, local anticancer drug delivery and hyperthermia

2014 ◽  
Vol 2 (43) ◽  
pp. 7583-7595 ◽  
Author(s):  
Jianhua Zhang ◽  
Shichang Zhao ◽  
Min Zhu ◽  
Yufang Zhu ◽  
Yadong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bone Regeneration ◽  
Tumor Resection ◽  
Bone Defects ◽  
Composite Scaffolds ◽  
Anticancer Drug Delivery ◽  
3D Printed ◽  
Large Bone ◽  
Large Bone Defects ◽  
Magnetic Fe3o4

The 3D-printed Fe3O4/MBG/PCL scaffolds with potential multifunctionality would be promising for use in the treatment and regeneration of large bone defects after tumor resection.

Sign in / Sign up

Export Citation Format

Share Document