3D-printed magnetic Fe3O4/MBG/PCL composite scaffolds with multifunctionality of bone regeneration, local anticancer drug delivery and hyperthermia

2014 ◽  
Vol 2 (43) ◽  
pp. 7583-7595 ◽  
Author(s):  
Jianhua Zhang ◽  
Shichang Zhao ◽  
Min Zhu ◽  
Yufang Zhu ◽  
Yadong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bone Regeneration ◽  
Tumor Resection ◽  
Bone Defects ◽  
Composite Scaffolds ◽  
Anticancer Drug Delivery ◽  
3D Printed ◽  
Large Bone ◽  
Large Bone Defects ◽  
Magnetic Fe3o4

The 3D-printed Fe3O4/MBG/PCL scaffolds with potential multifunctionality would be promising for use in the treatment and regeneration of large bone defects after tumor resection.

Composite Scaffolds for Large Bone Defects

2019 ◽  
pp. 250-257
Author(s):  
Evangelos Daskalakis ◽  
Enes Aslan ◽  
Fengyuan Liu ◽  
Glen Cooper ◽  
Andrew Weightman ◽  
...  
Keyword(s):  
Bone Defects ◽  
Composite Scaffolds ◽  
Large Bone ◽  
Large Bone Defects

scholarly journals Treatment possibilities of jaws bone defects: A case report

2010 ◽  
Vol 57 (1) ◽  
pp. 49-53
Author(s):  
Nenad Tanaskovic ◽  
Sinisa Ristic ◽  
Miroslav Lucic
Keyword(s):  
Bone Regeneration ◽  
Bone Destruction ◽  
Bone Defects ◽  
Significant Loss ◽  
Bone Augmentation ◽  
Surrounding Soft Tissue ◽  
Prosthetic Reconstruction ◽  
Previous Trauma ◽  
Large Bone ◽  
Large Bone Defects

Large bone defects in the jaws can occur as a result of previous trauma, tumor or bone destruction caused by infection. Significant loss of bone volume also may be caused by premature loss of teeth, application of inadequate extraction technique, periodontitis or trauma caused by incorrect prosthetic reconstruction. Very few of these defects are treated using materials for bone augmentation or regeneration in order to preserve the total volume of bone. Depending on the size of a defect, spontaneous bone regeneration of untreated defects is limited by proliferation of surrounding soft tissue. Bone replacement by connective tissue leads to loss of stability, reduces function and disturbs anatomical form of the jaws. The aim of the study was to present a case from clinical praxis which demonstrates bone regeneration provided by bone substitute or its combination with bone grafts.

Bone Transport Osteogenesis for Limb Salvage

2000 ◽  
Vol 13 (01) ◽  
pp. 18-22 ◽  
Author(s):  
M. Degna ◽  
A. Feretti ◽  
P. Buracco ◽  
Nicole Ehrhart
Keyword(s):  
Surgical Technique ◽  
Limb Salvage ◽  
Tumor Resection ◽  
Bone Defects ◽  
Bone Transport ◽  
Successful Outcome ◽  
Strict Adherence ◽  
Initial Learning ◽  
Large Bone ◽  
Large Bone Defects

Six dogs with osteosarcoma of the radius were treated by local resection and limb salvage using bone transport osteogenesis. One case is described in detail. Although the initial learning curve is steep for this technique, strict adherence to oncologic surgical technique and the principles of Ilizarov can lead to a successful outcome. Bone transport shows promise as an alternative to cortical allografts for reconstruction of large bone defects after tumor resection in the canine radius.

scholarly journals Improved Bone Regeneration in Rabbit Bone Defects Using 3D Printed Composite Scaffolds Functionalized with Osteoinductive Factors

2020 ◽  
Vol 12 (43) ◽  
pp. 48340-48356
Author(s):  
Arun Kumar Teotia ◽  
Kasper Dienel ◽  
Irfan Qayoom ◽  
Bas van Bochove ◽  
Sneha Gupta ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defects ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Rabbit Bone

scholarly journals The Current and Future Therapies of Bone Regeneration to Repair Bone Defects

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Eijiro Jimi ◽  
Shizu Hirata ◽  
Kenji Osawa ◽  
Masamichi Terashita ◽  
Chiaki Kitamura ◽  
...  
Keyword(s):  
Stem Cell ◽  
Bone Regeneration ◽  
Effective Treatment ◽  
Surgical Stress ◽  
Tumor Resection ◽  
Bone Defects ◽  
Current Therapy ◽  
Autogenous Bone ◽  
Clinical Method ◽  
Large Bone

Bone defects often result from tumor resection, congenital malformation, trauma, fractures, surgery, or periodontitis in dentistry. Although dental implants serve as an effective treatment to recover mouth function from tooth defects, many patients do not have the adequate bone volume to build an implant. The gold standard for the reconstruction of large bone defects is the use of autogenous bone grafts. While autogenous bone graft is the most effective clinical method, surgical stress to the part of the bone being extracted and the quantity of extractable bone limit this method. Recently mesenchymal stem cell-based therapies have the potential to provide an effective treatment of osseous defects. In this paper, we discuss both the current therapy for bone regeneration and the perspectives in the field of stem cell-based regenerative medicine, addressing the sources of stem cells and growth factors used to induce bone regeneration effectively and reproducibly.

scholarly journals 3D printed scaffold combined to 2D osteoinductive coatings to repair a critical-size mandibular bone defect

2020 ◽  
Author(s):  
Michael Bouyer ◽  
Charlotte Garot ◽  
Paul Machillot ◽  
Julien Vollaire ◽  
Vincent Fitzpatrick ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Repair ◽  
Critical Size ◽  
Bone Defects ◽  
Dose Dependence ◽  
Mandibular Bone ◽  
3D Printed ◽  
Bone Autograft ◽  
Large Bone ◽  
Large Bone Defects

Abstractthe reconstruction of large bone defects (12 cm3) remains a challenge for clinicians. We developed a new critical-size mandibular bone defect model on a mini-pig, close to human clinical issues. We analyzed the bone reconstruction obtained by a 3D printed scaffold made of clinical-grade PLA, coated with a polyelectrolyte film delivering an osteogenic bioactive molecule (BMP-2). We compared the results (CT-scan, μCT, histology) to the gold standard solution, bone autograft. We demonstrated that the dose of BMP-2 delivered from the scaffold significantly influenced the amount of regenerated bone and the repair kinetics, with a clear BMP-2 dose-dependence. Bone was homogeneously formed inside the scaffold without ectopic bone formation. The bone repair was as good as for the bone autograft. The BMP-2 doses applied in our study were reduced 20 to 75-fold compared to the commercial collagen sponges used in the current clinical applications, without any adverse effects. 3D printed PLA scaffolds loaded with reduced doses of BMP-2 can be a safe and simple solution for large bone defects faced in the clinic.

In situ mineralized PLGA/zwitterionic hydrogel composite scaffolds enable high-efficiency rhBMP‑2 release for critical-sized bone healing

2022 ◽  
Author(s):  
Peiming Liu ◽  
Tianyi Bao ◽  
Lian Sun ◽  
Zeyi Wang ◽  
Jin Sun ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
High Efficiency ◽  
Ammonium Hydroxide ◽  
Bone Defects ◽  
Functional Restoration ◽  
Composite Scaffolds ◽  
Hydrogel Composite ◽  
Large Bone ◽  
Large Bone Defects

Seeking an osteoconductive and osteoinductive scaffold is highly desirable for functional restoration of large bone defects. Here, we report an in situ mineralized poly(lactic-co-glycolic acid)/poly[2-(methacryloyloxy)ethyl] dimethyl-(3-sulfopropyl)ammonium hydroxide hydrogel (PLGA/PSBMA) scaffolds...

Strontium-calcium phosphate hybrid cement with enhanced osteogenic and angiogenic properties for vascularised bone regeneration

2021 ◽  
Author(s):  
Xiexing Wu ◽  
Ziniu Tang ◽  
Kang Wu ◽  
Yanjie Bai ◽  
X. LIN ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Calcium Phosphate Cement ◽  
Treatment Options ◽  
Bone Defects ◽  
Large Bone ◽  
Large Bone Defects ◽  
Vascularized Bone

Vascularized bone tissue engineering is regarded as one of the optimal treatment options for large bone defects. The lack of angiogenic property and unsatisfactory physicochemical performance restricts calcium phosphate cement...

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