scholarly journals ITHANET: Information and database community portal for haemoglobinopathies

2017 ◽  
Author(s):  
Petros Kountouris ◽  
Coralea Stephanou ◽  
Celeste Bento ◽  
Pavlos Fanis ◽  
Jacques Elion ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Clinical Data ◽  
Health Professionals ◽  
Epidemiological Data ◽  
Online Resources ◽  
The Public ◽  
Genetic Complexity ◽  
Monogenic Diseases ◽  
The World ◽  
Community Portal

ABSTRACTHaemoglobinopathies are the commonest monogenic diseases, with millions of carriers and patients worldwide. Online resources for haemoglobinopathies are largely divided into specialised sites catering for patients, researchers and clinicians separately. However, the severity, ubiquity and surprising genetic complexity of the haemoglobinopathies call for an integrated website to serve as a free and comprehensive repository and tool for patients, scientists and health professionals alike. This paper presents the ITHANET community portal, an expanding resource for clinicians and researchers dealing with haemoglobinopathies. It integrates information on news, events, publications, clinical trials and haemoglobinopathy-related organisations and experts and, most importantly, databases of variations, epidemiology and diagnostic and clinical data. Specifically, ITHANET provides annotation for 2690 haemoglobinopathy-related variations, epidemiological data for more than 180 countries and information for more than 600 HPLC diagnostic reports. The ITHANET portal accepts and incorporates contributions to its content by local experts from any country in the world and is freely available for the public at http://www.ithanet.eu.

scholarly journals Virus Eradication and Synthetic Biology: Changes with SARS-CoV-2?

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 569
Author(s):  
Jean-Nicolas Tournier ◽  
Joseph Kononchik
Keyword(s):  
Clinical Trials ◽  
Synthetic Biology ◽  
Viral Disease ◽  
Virus Eradication ◽  
Disease Eradication ◽  
The Public ◽  
The Past ◽  
The World ◽  
Significant Effort

The eradication of infectious diseases has been achieved only once in history, in 1980, with smallpox. Since 1988, significant effort has been made to eliminate poliomyelitis viruses, but eradication is still just out of reach. As the goal of viral disease eradication approaches, the ability to recreate historically eradicated viruses using synthetic biology has the potential to jeopardize the long-term sustainability of eradication. However, the emergence of the severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 pandemic has highlighted our ability to swiftly and resolutely respond to a potential outbreak. This virus has been synthetized faster than any other in the past and is resulting in vaccines before most attenuated candidates reach clinical trials. Here, synthetic biology has the opportunity to demonstrate its truest potential to the public and solidify a footing in the world of vaccines.

scholarly journals Pancreatic Cancers: A Review of Studies from Pakistan and Comparison with Global Trends

2021 ◽  
Vol 11 (2) ◽  
pp. 120-127
Author(s):  
Saleema Mehboob Ali ◽  
Yumna Adnan ◽  
S. M. Adnan Ali
Keyword(s):  
Pancreatic Cancer ◽  
Clinical Data ◽  
Association Studies ◽  
Epidemiological Data ◽  
Review Article ◽  
Diagnostic Tools ◽  
Global Trends ◽  
Pancreatic Cancers ◽  
The World ◽  
Prediction Of Prognosis

The objective of this review article is to discuss clinical data from studies on Pakistani pancreatic cancer population and its comparison with international data. This review article will allow researchers to identify gaps in the data and hence to design further research in order to address these gaps accordingly. Search was carried out via Google Scholar, PubMed and PakMediNet search engines using keywords “Pancreatic cancers”, “Pancreatic adenocarcinoma” and “Pakistan”. Pancreatic cancers are one of the most lethal cancers globally. Statistics show that 97.8% of cases of pancreatic cancers in Pakistan have led to mortality. For various cancers around the world, epidemiological data has been used for development of diagnostic tools and therapies. Despite the alarming situation of pancreatic cancers in Pakistan, only limited work has been done in this area. Majority of the studies are based exclusively on reporting of clinical data. Pakistan has not been able to even gather sufficient data to proceed research based on association of molecular aspects of tumor with clinical characteristics. On the contrary, researchers, scientists and clinicians from other parts of the world are already working on association studies, prediction of prognosis, treatment selection and improving the survival of their population. It is an immense need of the situation that molecular based studies are carried out on Pakistani pancreatic cancer population so that diagnosis, prognosis, treatment and survival of these patients can be made better.

Case Study E-Tailing Health Services in India

2016 ◽  
pp. 292-308
Author(s):  
Bobby Kurian
Keyword(s):  
Health Care ◽  
Health Services ◽  
Health Professionals ◽  
Health Care Services ◽  
Information Dissemination ◽  
Health Providers ◽  
The Public ◽  
Care Services ◽  
The World

This case study has been developed to promote understanding the e-tailing of health services. E-health web portal provides a new medium for information dissemination, interaction and collaboration among institutions, health professionals, health providers and the public. This case study provides a founders perspective in setting up and running a medical website that offers online health care services to customers across the world. The case study discusses the challenges and issues faced by the founders and also the promoter's perspective on the lucrativeness of offering e-tailing services. Using this case study an attempt is made to stress the importance of a flexible e-tailing business model specific to the services offered and need of periodic assessments to ensure that the business runs profitable.

scholarly journals Public Health Literacy for Lawyers

2003 ◽  
Vol 31 (4) ◽  
pp. 701-713 ◽  
Author(s):  
Wendy E. Parmet ◽  
Anthony Robbins
Keyword(s):  
Public Health ◽  
Health Professionals ◽  
Critical Role ◽  
The Public ◽  
Health Measures ◽  
Public Health Professionals ◽  
The World ◽  
Key Issues ◽  
Public Health Literacy

Public health professionals recognize the critical role the law plays in determining the success of public health measures. Even before September 11, 2001, public health experience with tobacco use, HIV, industrial pollution and other potent threats to the health of the public demonstrated that laws can assist or thwart public health efforts. The new focus on infectious threats and bioterrorism, starting with the anthrax attacks through the mail and continuing with SARS, has highlighted the important role of law.For lawyers to serve as effective partners in public health, they should have a basic familiarity with public health: how public health professionals see the world and the key issues they tackle. A practical grasp of public health can be acquired, and often is acquired, “on the job.”

scholarly journals Clinical trial search portal launched

2007 ◽  
Vol 12 (19) ◽  
Author(s):  
Collective Editorial team
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
World Health Organisation ◽  
Target Audience ◽  
World Health ◽  
The Public ◽  
Health Practitioners ◽  
The World ◽  
Search For Information ◽  
International Initiative

On 4 May 2007, the Clinical Trial Search Portal (http://www.who.int/trialsearch) was launched. An international initiative led by the World Health Organisation (WHO), the portal aims to ease the rapid search for information about clinical trials worldwide. It is open to the public, but its target audience is health practitioners and researchers.

scholarly journals Analysing the Launch of COVID-19 Vaccine National Rollouts: Nine Case Studies

Epidemiologia ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 519-539
Author(s):  
John Gannon ◽  
Razieh Azari ◽  
Marta Lomazzi ◽  
Bettina Borisch
Keyword(s):  
United States ◽  
Clinical Trials ◽  
United Kingdom ◽  
Case Studies ◽  
Regulatory Approval ◽  
Immunization Programs ◽  
The Public ◽  
News Reports ◽  
Government Documents ◽  
The World

In late 2020 and early 2021, with the eagerly anticipated regulatory approval of vaccines against SARS-CoV-2, the urgent global effort to inoculate populations against this devastating virus was underway. These case studies examine the early stages of COVID-19 vaccine rollouts across nine regions from around the world (Brazil, India, Indonesia, Ireland, Israel, Nigeria, Taiwan, United Kingdom and United States). By evaluating and comparing different approaches used to immunize against a novel pathogen, it is possible to learn a great deal about which methods were successful, and in which areas strategies can be improved. This information is applicable to the ongoing global vaccination against this virus, as well as in the event of future pandemics. Research was conducted by following and tracking the progress of vaccine rollouts in the nine regions, using published clinical trials, government documents and news reports as sources of data. Results relate to the proportion of populations that had received at least one COVID-19 dose by 28 February 2021. Outcomes are discussed in the context of three key pillars integral to all immunization programs: procurement of vaccines, communication with the public and distribution of doses to individuals.

scholarly journals Favipiravir: A Critical Review of Pharmacology, Pre-Clinical Data, and Emerging Clinical Uses in COVID-19

2021 ◽  
Vol 9 (8) ◽  
pp. 2521-2527
Author(s):  
Anuja S. Motule
Keyword(s):  
Clinical Trials ◽  
Drug Treatment ◽  
Viral Infection ◽  
Clinical Data ◽  
Critical Review ◽  
Virus Disease ◽  
Antiviral Drug ◽  
Veterinary Drugs ◽  
Evidence Based ◽  
The World

Abstract: Since last two years, whole world is going through the pandemic situation of Corona Virus Disease-19 (COVID-19). It caused more than 43 lakhs deaths worldwide. COVID-19 outbreak all over the world has led the researchers and Scientists to develop drugs or vaccines to prevent the spreading of this virus. Due to the unavailabity of proper drug treatment, various veterinary drugs are trying in humans. It is one of such type of antiviral drug which was previously used in treatment of viral infection in animals and birds. In this article, we have tried to provide a comprehensive, evidence-based review of this drug in the context of the present pandemic to elucidate its role in the management of COVID-19. Keywords: Favipiravir; Pharmacology; COVID-19; Antiviral; Clinical trials.

scholarly journals Japanese pharmaceutical and regulatory environment

2002 ◽  
Vol 4 (4) ◽  
pp. 470-474 ◽  
Keyword(s):  
Clinical Trials ◽  
Drug Development ◽  
Clinical Data ◽  
Regulatory Authority ◽  
Regulatory Environment ◽  
International Guidelines ◽  
Regulatory Authorities ◽  
Regulatory Changes ◽  
The World ◽  
Considerable Impact

Drastic regulatory changes in Japan since 1997 have had a considerable impact on the way new medicines are developed. The regulatory authority itself has been transformed. Clinical trials are now performed according to international guidelines. Clinical data generated in one area are acceptable in the rest of the world in some cases through a bridging process that is viewed as only temporary. The future of drug development lies in multinational clinical trials and simultaneous submission to the major regulatory authorities.

scholarly journals A Glossary in Support of Physicians' Continuing Professional Development Across the World

2018 ◽  
Vol 104 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Amy L. Smith ◽  
Kate Regnier ◽  
Mindi K. McKenna ◽  
Mark L. Staz ◽  
Mya A. Warken
Keyword(s):  
Professional Development ◽  
Health Professionals ◽  
Continuing Professional Development ◽  
Common Language ◽  
The Public ◽  
Practice Performance ◽  
The World ◽  
Physician Learning ◽  
International Academy

ABSTRACT As the physician learning environment becomes more global, the importance of a common language for CME/CPD is becoming increasingly important in order that physicians, the regulatory community, and the public may grasp the meaning of particular terms and understand the context in which they are being used. Establishment of a common language for continuing professional development is essential for developing substantive equivalency agreements among regulatory jurisdictions and improving the quality of CME/CPD systems worldwide. The International Academy for CPD Accreditation (IACPDA) developed a glossary of commonly used terms and consensus-based definitions of those terms. There is not an expectation that accrediting bodies must change their terminology to conform to the glossary. Rather, the intent is for the glossary to facilitate greater understanding and potential for harmonization of standards among CME/CPD accreditors, certifying boards, medical regulatory authorities and other stakeholders, thus enabling improvement worldwide in the quality of CME/CPD activities in which health professionals participate, and therefore improvement in their competence and practice performance. This article highlights synergies created by a standardization in CME/CPD terminology and summarizes the methodology used, and design of, the new glossary of terminology by the IACPDA. While the IACPDA has identified modifications and enhancements to be incorporated into future updates, the current glossary is already publicly accessible. The IACPDA welcomes comments from all stakeholders, including the medical regulatory community.

scholarly journals Modeling the Population Health Impact of Introducing a Modified Risk Tobacco Product into the U.S. Market

2018 ◽  
Author(s):  
Smilja Djurdjevic ◽  
Peter N. Lee ◽  
Rolf Weitkunat ◽  
Zheng Sponsiello-Wang ◽  
Frank Lüdicke ◽  
...  
Keyword(s):  
Population Health ◽  
Epidemiological Data ◽  
Health Impact ◽  
Tobacco Product ◽  
World Health ◽  
The Public ◽  
Philip Morris ◽  
The World ◽  
Health Organization ◽  
The U.S

Philip Morris International (PMI) has developed the Population Health Impact Model (PHIM) to quantify, in the absence of epidemiological data, the effects of marketing a candidate modified risk tobacco product (cMRTP) on the public health of a whole population. Various simulations were performed to understand the harm reduction impact on the U.S. population over a 20-year period under various scenarios. The overall reduction in smoking attributable deaths (SAD) over the 20-year period was estimated as 934,947 if smoking completely went away and between 516,944 and 780,433 if cMRTP use completely replaces smoking. The reduction in SADs was estimated as 172,458 for the World Health Organization (WHO) 2025 Target and between 70,274 and 90,155 for the gradual cMRTP uptake. Combining the scenarios (WHO 2025 Target and cMRTP uptake), the reductions were between 256,453 and 268,796, depending on the cMRTP effective dose. These results show how a cMRTP can reduce overall population harm additionally to existing tobacco control efforts.

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