scholarly journals A Multi-Parameter Analysis of Cellular Coordination of Major Transcriptome Regulation Mechanisms

2017 ◽  
Author(s):  
Wen Jiang ◽  
Zhanyong Guo ◽  
Nuno Lages ◽  
W. Jim Zheng ◽  
Denis Feliers ◽  
...  
Keyword(s):  
Mrna Stability ◽  
Regulatory Mechanism ◽  
Negative Relationship ◽  
Parameter Analysis ◽  
Regulatory Mechanisms ◽  
Statistical Features ◽  
Transcriptome Regulation ◽  
Coordination Process ◽  
Regulation Mechanisms ◽  
The Relationship

AbstractTo understand cellular coordination of multiple transcriptome regulation mechanisms, we simultaneously measured transcription rate (TR), mRNA abundance (RA) and translation activity (TA). This revealed multiple quantitative insights. First, the genomic profiles of the three parameters are systematically different in key statistical features. Sequentially more genes exhibit extreme low or high expression values from TR to RA, then to TA. That is, because of cellular coordination of these regulatory mechanisms, sequentially higher levels of gene expression selectivity are achieved as genetic information flow from the genome to the proteome. Second, the contribution of the stabilization-by-translation regulatory mechanism to the cellular coordination process was assessed. The data enabled an estimation of mRNA stability, revealing a moderate but significant positive correlation between the estimated mRNA stability and translation activity. Third, the proportion of a mRNA occupied by un-translated regions (UTR) exhibits a negative relationship with the level of this correlation, and is thus a major determinant of the mode of regulation of the mRNA. High-UTR-proportion mRNAs tend to defy the stabilization-by-translation regulatory mechanism, staying out of the polysome but remaining stable; mRNAs with little UTRs largely follow this regulation. In summary, we quantitatively delineated the relationship among multiple transcriptome regulation parameters, i.e., cellular coordination of corresponding regulatory mechanisms.

scholarly journals A Multi-Parameter Analysis of Cellular Coordination of Major Transcriptome Regulation Mechanisms

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Wen Jiang ◽  
Zhanyong Guo ◽  
Nuno Lages ◽  
W. Jim Zheng ◽  
Denis Feliers ◽  
...  
Keyword(s):  
Parameter Analysis ◽  
Transcriptome Regulation ◽  
Regulation Mechanisms

Risk Attitude and Corporate Investment under Output Market Uncertainty: Evidence from The Mekong River Delta, Vietnam

2016 ◽  
pp. 59-70
Author(s):  
Ninh Le Khuong ◽  
Nghiem Le Tan ◽  
Tho Huynh Huu
Keyword(s):  
Negative Relationship ◽  
Risk Attitude ◽  
Business Strategies ◽  
Risk Averse ◽  
Market Uncertainty ◽  
Firm Investment ◽  
Output Market ◽  
The Impact ◽  
The Relationship

This paper aims to detect the impact of firm managers’ risk attitude on the relationship between the degree of output market uncertainty and firm investment. The findings show that there is a negative relationship between these two aspects for risk-averse managers while there is a positive relationship for risk-loving ones, since they have different utility functions. Based on the findings, this paper proposes recommendations for firm managers to take into account when making investment decisions and long-term business strategies as well.

Relationship of Organizational Citizenship Behavior and Production Deviance: Role of Perceived Organizational Politics

2019 ◽  
Vol 34 (2) ◽  
pp. 367-382
Author(s):  
Irsa Fatima Makhdoom ◽  
Mohsin Atta ◽  
Najma Iqbal Malik
Keyword(s):  
Organizational Citizenship ◽  
Organizational Citizenship Behavior ◽  
Negative Relationship ◽  
Civic Virtue ◽  
Organizational Politics ◽  
Work Behavior ◽  
Citizenship Behavior ◽  
Production Deviance ◽  
Relationship Of ◽  
The Relationship

The present study was an endeavor to extend the literature of perceived organizational politics by examining its moderating role between the relationship of organizational citizenship behavior and production deviance. Organizational Citizenship Behavior Scale (Mackenzie, Podsakoff, & Paine, 1999), Production Deviance sub-scale of Counterproductive Work Behavior Checklist-32 (Spector et al., 2006), and Perception of Organizational Politics Scale (Kacmar & Carlson, 1997) were used in present study. Hierarchical regression analyses revealed that low levels of perceived organizational politics moderated the relationship between courtesy and production deviance by strengthening the negative relationship of these behaviors while perceived organizational politics did not act as a moderator for the relationship of civic virtue and conscientiousness with production deviance. High level of go-along-to-get-ahead as a moderator strengthened the relationship of civic virtue and conscientiousness with production deviance and its low level was found to be moderating the relationship between courtesy and production deviance. Future implications of the study were also discussed.

Work Stress and Organisational Citizenship Behaviours (OCBs) in Call Centers Employees

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Sunita ◽  
Urvashi Singh ◽  
Shalini Singh ◽  
Rajnee Sharma
Keyword(s):  
Negative Impact ◽  
Call Centers ◽  
Negative Relationship ◽  
Married Couples ◽  
Call Centre ◽  
Simple Correlation ◽  
Nuclear Families ◽  
Set Up ◽  
Stress At Work ◽  
The Relationship

The present study was conducted to examine the relationship between organisational stress and organisational citizenship behaviours (OCBs) in employees of call centers. The study also further explored as how stress at work set-up has negative impact on OCBs. A sample of 250 employees working in call centre of Gurgaon belonging to an age group of 25-30 years were selected on availability basis. All were working married couples living in nuclear families. Job stress survey (Spielberger & Vagg, 1999) and Organisational Citizenship Behaviour (Bateman & Organ, 1983) were administered. Data was analysed by using simple correlation and multiple regression. Results showed the negative relationship between organisational stress and OCBs. Results of regression analysis also exhibited the negative impact of stress on OCBs. The implications for the employees are discussed.

The Relationship Among Job Satisfaction, Oreganizational Commitiment and Employees’ Turnover at Unilever Corporation in Nigeria

2017 ◽  
Vol 5 (1) ◽  
pp. 370
Author(s):  
Chiemeke Kingsley Chiedu ◽  
Choi Sang Long ◽  
Hapriza BT Ashar
Keyword(s):  
Job Satisfaction ◽  
Organizational Commitment ◽  
Organizational Performance ◽  
Employee Turnover ◽  
Turnover Intentions ◽  
Pearson Correlation ◽  
Negative Relationship ◽  
Survey Method ◽  
Employee Turnover Intentions ◽  
The Relationship

Employee turnover has become a key performance indicator for many organizations as they struggle to retain talented employees. The negative impact of turnover on organizational performance has continually forced organizational leaders to seek better ways of retaining valuable employees. The relationship between man and work has always attracted the attention of philosophers. A major part of men’s life is spent at work. Work is social reality and social expectation to which men seem to conform. It not only provides status to the individual but also binds him to the society. An employee who is satisfied with his job would perform his duties well and be committed to his job, and subsequently to his organization. This paper examines relationship among job satisfaction, organizational commitment and employees’ turnover intentions at Unilever Corporation in Nigeria. The data for this study was collected from 117 employees currently working at Unilever Nigeria PLC using the survey method via the questionnaire. Pearson Correlation and the multiple regression analysis techniques using the SPSS version 22.0 was used for the data analysis. The findings of the study revealed that both job satisfaction and organizational commitment have significant negative relationship with employee turnover intentions. In addition, organizational commitment was revealed to have a more dorminant influence on employee turnover intentions than job satisfaction. Based on these findings, the implications, recommendations, practice, and theory were discussed.

Is NPA and Stock Return Related: An Empirical Study of Back Testing Model

2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Madhvi . ◽  
Amit Gautam ◽  
Amit Srivastava
Keyword(s):  
Data Analysis ◽  
Panel Data ◽  
Stock Price ◽  
Panel Data Analysis ◽  
Negative Relationship ◽  
Share Price ◽  
Correlation Studies ◽  
Back Testing ◽  
Trading Model ◽  
The Relationship

This paper examines the relationship between NPA announcements by banks and the impulsive movement in stock price brought out by these announcements. Primary focus of this study is to determine whether we can create a swing trading model based on back testing the data for the banking stocks listed on the Indian bourses.To achieve this objective we created a databasespanning ten years (2006 to 2016) and collected the daily share prices of eight banks listed on Bombay Stock Exchange (BSE). The relationship between share price and changes in NPA is studied on the basis of correlation studies and panel-data analysis. Although correlation studies does not establish any significant relationship, but the result of panel-data analysis clearly shows a negative relationship between the two. The result is further utilized to develop swing trading model and get benefit out of it. The novelty of the present study is that it clearly guides the swing traders as to how to earn benefit because of fluctuations in share price due to announce of NPA result.

Corporate Social Responsibility and Financial Reporting Quality:Evidence from Restatements

2020 ◽  
Author(s):  
Yi-Hung Lin ◽  
Hua-Wei (Solomon) Huang ◽  
Mark E. Riley ◽  
Chih-Chen Lee
Keyword(s):  
Financial Reporting ◽  
Negative Relationship ◽  
Reporting Quality ◽  
Financial Statements ◽  
Financial Statement ◽  
Financial Reporting Quality ◽  
Csr Reporting ◽  
Corporate Social ◽  
Reporting Environment ◽  
The Relationship

We find a negative relationship between aggregate CSR scores and the probability that firms restated financial statements over the period 1991-2012. We then break that period into three sub-periods in order to determine whether the relationship holds for all three sub-periods. During the sub-periods of 1991-2001 and 2002-2005, the negative CSR score - restatement probability relationship holds. The negative relationship disappears in the 2006-2012 sub-period. Additional analyses indicate CSR scores are significantly higher in the 2006-2012 sub-period, suggesting the disappearance of the relationship between aggregate CSR scores and financial statement quality may relate to changes in CSR assessments and the CSR reporting environment. Our findings update the literature linking CSR scores and financial reporting quality and identify the need for further research as to the reasons the link between these constructs disappeared.

Attachment to God and Quest as Moderators of the Relationship between Religious Doubt and Mental Health

2021 ◽  
pp. 009164712199240
Author(s):  
Noah S. Love ◽  
Cassidy A. Merlo ◽  
M. Elizabeth Lewis Hall ◽  
Peter C. Hill
Keyword(s):  
Mental Health ◽  
Positive Relationship ◽  
Mental Health Problems ◽  
Negative Relationship ◽  
Health Problems ◽  
Positive Mental Health ◽  
Attachment To God ◽  
Religious Doubt ◽  
Avoidant Attachment ◽  
The Relationship

The present study examined attachment to God and quest as potential moderators of the relationship between religious doubt and mental health. A sample of Christian participants ( N = 235) completed a survey which included measures of attachment to God, quest, religious doubt, and mental health. As hypothesized, attachment to God and quest significantly moderated an individual’s experience of religious doubt. Low avoidant attachment to God (i.e., a more secure attachment) was associated with a more negative relationship between cognitive religious doubt and positive mental health than high avoidant attachment. In contrast, low avoidant attachment to God also ameliorated the positive relationship between affective religious doubt and mental health problems. Low anxious attachment was associated with a stronger negative relationship between both measures of religious doubt (i.e., cognitive and affective) and positive mental health. In addition, high soft quest weakened all four of the relationships between measures of religious doubt and mental health. High hard quest ameliorated the positive relationship between both measures of religious doubt and mental health problems. These results indicate that an individual’s attachment to God and the way an individual is oriented toward religion each play a role in the mental health outcomes associated with religious doubt.

scholarly journals Role of interleukins in the pathogenesis of pulmonary fibrosis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yi Xin She ◽  
Qing Yang Yu ◽  
Xiao Xiao Tang
Keyword(s):  
Pulmonary Fibrosis ◽  
Therapeutic Strategy ◽  
Future Directions ◽  
Regulation Mechanisms ◽  
Underlying Mechanisms ◽  
Multiple Cells ◽  
The Relationship

AbstractInterleukins, a group of cytokines participating in inflammation and immune response, are proved to be involved in the formation and development of pulmonary fibrosis. In this article, we reviewed the relationship between interleukins and pulmonary fibrosis from the clinical, animal, as well as cellular levels, and discussed the underlying mechanisms in vivo and in vitro. Despite the effects of interleukin-targeted treatment on experimental pulmonary fibrosis, clinical applications are lacking and unsatisfactory. We conclude that intervening in one type of interleukins with similar functions in IPF may not be enough to stop the development of fibrosis as it involves a complex network of regulation mechanisms. Intervening interleukins combined with other existing therapy or targeting interleukins affecting multiple cells/with different functions at the same time may be one of the future directions. Furthermore, the intervention time is critical as some interleukins play different roles at different stages. Further elucidation on these aspects would provide new perspectives on both the pathogenesis mechanism, as well as the therapeutic strategy and drug development.

Hours of Paid Work and Volunteering: Evidence From Danish Panel Data

2021 ◽  
pp. 089976402199166
Author(s):  
Hans-Peter Y. Qvist
Keyword(s):  
Panel Data ◽  
Social Integration ◽  
Negative Relationship ◽  
Time Constraint ◽  
Integration Theory ◽  
Paid Work ◽  
Constraint Theory ◽  
The Social ◽  
Negative Effect ◽  
The Relationship

The nature of the relationship between the time people spend on paid work and volunteering remains debated in the social sciences. Time constraint theory suggests a negative relationship because people can allocate only as much time to volunteering as their work responsibilities permit. However, social integration theory suggests a more complex inverse U-shaped relationship because paid work not only limits people’s free time but also plays a key role in their social integration. Departing from these competing theories, this study uses two-wave panel data from Denmark to examine the relationship between hours of paid work and volunteering. In support of time constraint theory, the results suggest that hours of paid work have a significant negative effect on the total number of hours that people spend volunteering, not mainly because paid work hours affect people’s propensity to volunteer but because they affect the number of hours that volunteers contribute.

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