scholarly journals Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments

2011 ◽  
Vol 9 (68) ◽  
pp. 401-419 ◽  
Author(s):  
Viviana Mouriño ◽  
Juan Pablo Cattalini ◽  
Aldo R. Boccaccini
Keyword(s):  
Tissue Engineering ◽  
Future Research ◽  
Biological Applications ◽  
Metallic Ions ◽  
Design Strategies ◽  
Tissue Engineering Scaffolds ◽  
New Developments ◽  
Biomaterial Scaffolds ◽  
Key Variables ◽  
Potential Use

This article provides an overview on the application of metallic ions in the fields of regenerative medicine and tissue engineering, focusing on their therapeutic applications and the need to design strategies for controlling the release of loaded ions from biomaterial scaffolds. A detailed summary of relevant metallic ions with potential use in tissue engineering approaches is presented. Remaining challenges in the field and directions for future research efforts with focus on the key variables needed to be taken into account when considering the controlled release of metallic ions in tissue engineering therapeutics are also highlighted.

scholarly journals Oral Bone Tissue Engineering: Advanced Biomaterials for Cell Adhesion, Proliferation and Differentiation

Materials ◽  
2019 ◽  
Vol 12 (14) ◽  
pp. 2296 ◽  
Author(s):  
Alexandra Roi ◽  
Lavinia Cosmina Ardelean ◽  
Ciprian Ioan Roi ◽  
Eugen-Radu Boia ◽  
Simina Boia ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Adhesion ◽  
Bone Regeneration ◽  
Surface Characteristics ◽  
Future Research ◽  
Biomaterial Scaffold ◽  
Proliferation And Differentiation ◽  
Biomaterial Scaffolds ◽  
Oral Tissue ◽  
Advanced Biomaterials

The advancements made in biomaterials have an important impact on oral tissue engineering, especially on the bone regeneration process. Currently known as the gold standard in bone regeneration, grafting procedures can sometimes be successfully replaced by a biomaterial scaffold with proper characteristics. Whether natural or synthetic polymers, biomaterials can serve as potential scaffolds with major influences on cell adhesion, proliferation and differentiation. Continuous research has enabled the development of scaffolds that can be specifically designed to replace the targeted tissue through changes in their surface characteristics and the addition of growth factors and biomolecules. The progress in tissue engineering is incontestable and research shows promising contributions to the further development of this field. The present review aims to outline the progress in oral tissue engineering, the advantages of biomaterial scaffolds, their direct implication in the osteogenic process and future research directions.

Advances and Trends in Tissue Engineering of Teeth

2010 ◽  
pp. 123-133
Author(s):  
Shital Patel ◽  
Yos Morsi
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Tooth Loss ◽  
Future Research ◽  
Tooth Replacement ◽  
Tissue Engineering Scaffolds ◽  
Dental Origin

Tooth loss due to several reasons affects most people adversely at some time in their lives. A biological tooth substitute, which could not only replace lost teeth but also restore their function, could be achieved by tissue engineering. Scaffolds required for this purpose, can be produced by the use of various techniques. Cells, which are to be seeded onto these scaffolds, can range from differentiated ones to stem cells both of dental and non-dental origin. This chapter deals with overcoming the drawbacks of the currently available tooth replacement techniques by tissue engineering, the success achieved in it at this stage and suggestion on the focus for future research.

scholarly journals Chitosan and Its Potential Use as a Scaffold for Tissue Engineering in Regenerative Medicine

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Martin Rodríguez-Vázquez ◽  
Brenda Vega-Ruiz ◽  
Rodrigo Ramos-Zúñiga ◽  
Daniel Alexander Saldaña-Koppel ◽  
Luis Fernando Quiñones-Olvera
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Biomedical Applications ◽  
Therapeutic Strategy ◽  
Biological Properties ◽  
Natural Polymers ◽  
Tissue Engineering Scaffolds ◽  
Promising Alternative ◽  
Functional Biomaterials ◽  
Potential Use

Tissue engineering is an important therapeutic strategy to be used in regenerative medicine in the present and in the future. Functional biomaterials research is focused on the development and improvement of scaffolding, which can be used to repair or regenerate an organ or tissue. Scaffolds are one of the crucial factors for tissue engineering. Scaffolds consisting of natural polymers have recently been developed more quickly and have gained more popularity. These include chitosan, a copolymer derived from the alkaline deacetylation of chitin. Expectations for use of these scaffolds are increasing as the knowledge regarding their chemical and biological properties expands, and new biomedical applications are investigated. Due to their different biological properties such as being biocompatible, biodegradable, and bioactive, they have given the pattern for use in tissue engineering for repair and/or regeneration of different tissues including skin, bone, cartilage, nerves, liver, and muscle. In this review, we focus on the intrinsic properties offered by chitosan and its use in tissue engineering, considering it as a promising alternative for regenerative medicine as a bioactive polymer.

Novel tissue engineering scaffolds as wound dressings loaded with Alkannins/Shikonins as active ingredients

2019 ◽  
Author(s):  
AS Arampatzis ◽  
K Theodoridis ◽  
E Aggelidou ◽  
KN Kontogiannopoulos ◽  
I Tsivintzelis ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Dressings ◽  
Active Ingredients ◽  
Tissue Engineering Scaffolds

HYDROXYAPATITE, ALGINATE, AND CHITOSAN FOR BONE SCAFFOLDS: SPECTROSCOPY STUDY

2016 ◽  
Vol 19 (2) ◽  
pp. 93-100
Author(s):  
Lalita El Milla
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Functional Groups ◽  
Bone Growth ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Powder ◽  
Materials Used

Scaffolds is three dimensional structure that serves as a framework for bone growth. Natural materials are often used in synthesis of bone tissue engineering scaffolds with respect to compliance with the content of the human body. Among the materials used to make scafffold was hydroxyapatite, alginate and chitosan. Hydroxyapatite powder obtained by mixing phosphoric acid and calcium hydroxide, alginate powders extracted from brown algae and chitosan powder acetylated from crab. The purpose of this study was to examine the functional groups of hydroxyapatite, alginate and chitosan. The method used in this study was laboratory experimental using Fourier Transform Infrared (FTIR) spectroscopy for hydroxyapatite, alginate and chitosan powders. The results indicated the presence of functional groups PO43-, O-H and CO32- in hydroxyapatite. In alginate there were O-H, C=O, COOH and C-O-C functional groups, whereas in chitosan there were O-H, N-H, C=O, C-N, and C-O-C. It was concluded that the third material containing functional groups as found in humans that correspond to the scaffolds material in bone tissue engineering.

Biomaterial scaffolds for tissue engineering

10.2741/e620 ◽  
2013 ◽  
Vol 5 (1) ◽  
pp. 341-360 ◽  
Author(s):  
Kajal K Mallick
Keyword(s):  
Tissue Engineering ◽  
Biomaterial Scaffolds

Biocompatiblibility analysis of the decellularized bovine pericardium

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
A. Sokol ◽  
◽  
D. Grekov ◽  
G. Yemets ◽  
O. Galkin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Sodium Dodecyl ◽  
Bovine Pericardium ◽  
Surrounding Tissue ◽  
Tissue Samples ◽  
Group I ◽  
Alternative Material ◽  
Decellularized Scaffolds ◽  
Group 2 ◽  
Potential Use

The decellularized bovine pericardium and its potential use as a natural scaffold is a promising approach in the field of tissue engineering and regenerative medicine. The reaction of the host toward decellularized scaffolds depends on their biocompatibility, which should be satisfied being before applied in clinical use. Purpose: to evaluate the biocompatibility of the extracellular matrices, which were decellularized by trypsin enzyme and anionic sodium dodecyl sulfate (SDS) detergent. Material and methods. Pericardial sacs were acquired from 12-18 months’ age bulls. Tissue decellularization was performed by using 0.25 % Trypsin solution and 1 % ionic SDS for group I and 0.1 % SDS for group II samples. The implantation was performed on Wistar rats. The tissue samples were stained with hematoxylin & eosin, Congo red and Masson's Trichrome for histological analysis. Results. In group 1 in 3 months after subcutaneous implantation in rats we noticed the inflammation in surrounding tissue and degradation of the implant. Under the same conditions in animals of group 2 implant replacement with growing immature connective tissue was noted. Bio-implant of this group did not degrade, moreover it's integrated to the tissues of experimental rats. Conclusion. Our results showed that decellularized bovine pericardium by 0.1 % SDS can become an alternative material for tissue engineering and has the potential for further use in human surgery.

Sign in / Sign up

Export Citation Format

Share Document