Biomaterial scaffolds for tissue engineering

10.2741/e620 ◽  
2013 ◽  
Vol 5 (1) ◽  
pp. 341-360 ◽  
Author(s):  
Kajal K Mallick
Keyword(s):  
Tissue Engineering ◽  
Biomaterial Scaffolds

scholarly journals Study on antibacterial properties and cytocompatibility of EPL coated 3D printed PCL/HA composite scaffolds

RSC Advances ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 4805-4816 ◽  
Author(s):  
Lijiao Tian ◽  
Zhenting Zhang ◽  
Bin Tian ◽  
Xin Zhang ◽  
Na Wang
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Critical Role ◽  
Antibacterial Properties ◽  
Composite Scaffolds ◽  
Biomaterial Scaffolds ◽  
3D Printed

Biomaterial scaffolds play a critical role in bone tissue engineering.

scholarly journals Liposomes in tissue engineering and regenerative medicine

2014 ◽  
Vol 11 (101) ◽  
pp. 20140459 ◽  
Author(s):  
Nelson Monteiro ◽  
Albino Martins ◽  
Rui L. Reis ◽  
Nuno M. Neves
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Potential Role ◽  
Lipid Membrane ◽  
Cultured Cells ◽  
Cell Types ◽  
Biomaterial Scaffolds ◽  
Bioactive Agents ◽  
The 1960S

Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches.

scholarly journals Applying elastic fibre biology in vascular tissue engineering

2007 ◽  
Vol 362 (1484) ◽  
pp. 1293-1312 ◽  
Author(s):  
Cay M Kielty ◽  
Simon Stephan ◽  
Michael J Sherratt ◽  
Matthew Williamson ◽  
C. Adrian Shuttleworth
Keyword(s):  
Tissue Engineering ◽  
Vascular Graft ◽  
Vascular Tissue ◽  
Small Diameter ◽  
Elastic Fibre ◽  
Vascular Tissue Engineering ◽  
Western Society ◽  
Elastic Recoil ◽  
Vessel Structure ◽  
Biomaterial Scaffolds

For the treatment of vascular disease, the major cause of death in Western society, there is an urgent need for tissue-engineered, biocompatible, small calibre artery substitutes that restore biological function. Vascular tissue engineering of such grafts involves the development of compliant synthetic or biomaterial scaffolds that incorporate vascular cells and extracellular matrix. Elastic fibres are major structural elements of arterial walls that can enhance vascular graft design and patency. In blood vessels, they endow vessels with the critical property of elastic recoil. They also influence vascular cell behaviour through direct interactions and by regulating growth factor activation. This review addresses physiological elastic fibre assembly and contributions to vessel structure and function, and how elastic fibre biology is now being exploited in small diameter vascular graft design.

scholarly journals Hyaluronic acid-based scaffold for central neural tissue engineering

2012 ◽  
Vol 2 (3) ◽  
pp. 278-291 ◽  
Author(s):  
Xiumei Wang ◽  
Jin He ◽  
Ying Wang ◽  
Fu-Zhai Cui
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Neural Tissue ◽  
Biological Properties ◽  
Point Of View ◽  
Neural Tissue Engineering ◽  
Cns Regeneration ◽  
Physico Chemical ◽  
Neuronal Connections ◽  
Biomaterial Scaffolds

Central nervous system (CNS) regeneration with central neuronal connections and restoration of synaptic connections has been a long-standing worldwide problem and, to date, no effective clinical therapies are widely accepted for CNS injuries. The limited regenerative capacity of the CNS results from the growth-inhibitory environment that impedes the regrowth of axons. Central neural tissue engineering has attracted extensive attention from multi-disciplinary scientists in recent years, and many studies have been carried out to develop cell- and regeneration-activating biomaterial scaffolds that create an artificial micro-environment suitable for axonal regeneration. Among all the biomaterials, hyaluronic acid (HA) is a promising candidate for central neural tissue engineering because of its unique physico-chemical and biological properties. This review attempts to outline current biomaterials-based strategies for CNS regeneration from a tissue engineering point of view and discusses the main progresses in research of HA-based scaffolds for central neural tissue engineering in detail.

Fabrication of Single and Multi-Layer Fibrous Biomaterial Scaffolds for Tissue Engineering

2008 ◽  
Author(s):  
Amrinder S. Nain ◽  
Eric Miller ◽  
Metin Sitti ◽  
Phil Campbell ◽  
Cristina Amon
Keyword(s):  
Tissue Engineering ◽  
Fiber Diameter ◽  
Living Cells ◽  
Cellular Adhesion ◽  
C2c12 Cells ◽  
Fiber Axis ◽  
Cellular Interactions ◽  
Fiber Spacing ◽  
Biomaterial Scaffolds ◽  
And Migration

For regenerative medicine applications, we need to expand our understanding of the mechanisms by which nature assembles and functionalizes specialized complex tissues to form a complete organism. The first step towards this goal involves understanding the underlying complex mechanisms of highly organized behavior spanning not only diverse scientific fields, but also nano, micro and macro length-scales. For example, an engineered fibrous biomaterial scaffold possessing the hierarchal spatial properties of a native extracellular matrix (ECM) can serve as a building block upon which living cells are seeded for repair or regeneration. The hierarchical nature of ECM along with the inherent topological constraints of fiber diameter, fiber spacing, multi-layer configurations provide different pathways for living cells to adapt and conform to the surrounding environment. Our previously developed Spinneret based Tunable Engineered Parameters (STEP) technique to deposit biomaterial scaffolds in aligned configurations has been used for the first time to deposit single and multi-layer biological scaffolds of fibrinogen. Fibrinogen is a very well established tissue engineering scaffold material, as it improves cellular interactions and allows scaffold remodeling compared to synthetic polymers. Current state-of-the-art fiber deposition techniques lack the ability to fabricate scaffolds of desired fiber dimensions and orientations and in this study we present fabrication and aligned deposition of fibrinogen fiber arrays with diameters ranging from sub-200 nm to sub-microns and several millimeters in length. The fabricated scaffolds are then cultured with pluripotent mouse C2C12 cells for seven days and cells on the scaffolds are observed to elongate resembling myotube morphology along the fiber axis, spread along intersecting layers and fuse into bundles at the macroscale. Additionally, we demonstrate the ability to deposit poly (lactic-co-glycolic acid) (PLGA), Polystyrene (PS) biomaterial scaffolds of different diameters to investigate the effects of topological variations on cellular adhesion, proliferation and migration. Previous studies have indicated cells making right angle transitions upon encountering perpendicular double layer fibers and cellular motion is thwarted in the vicinity of diverging fibers. Current ongoing studies are aimed at determining the effects of fiber diameter and fiber spacing on mouse C2C12 cellular adhesion and migration, which are envisioned to aid in the design of future scaffolds for tissue engineering possessing appropriate material and geometrical properties.

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