scholarly journals Marginal Zinc Deficiency Exacerbates Bone Lead Accumulation and High Dietary Zinc Attenuates Lead Accumulation at the Expense of Bone Density in Growing Rats

2006 ◽  
Vol 92 (1) ◽  
pp. 286-294 ◽  
Author(s):  
Jennifer A. Jamieson ◽  
Carla G. Taylor ◽  
Hope A. Weiler
Keyword(s):  
Bone Density ◽  
Zinc Deficiency ◽  
Dietary Zinc ◽  
Lead Accumulation ◽  
Growing Rats ◽  
Bone Lead ◽  
Marginal Zinc Deficiency

scholarly journals Relationship between abnormal sperm morphology induced by dietary zinc deficiency and lipid composition in testis of growing rats

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Miyoung Suh ◽  
Krystal Merrells ◽  
Heather Hosea ◽  
Jennifer Jamieson ◽  
Carla Taylor
Keyword(s):  
Zinc Deficiency ◽  
Lipid Composition ◽  
Sperm Morphology ◽  
Dietary Zinc ◽  
Growing Rats ◽  
Abnormal Sperm

scholarly journals Zinc Nutritional Status in Patients with Cystic Fibrosis

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 150 ◽  
Author(s):  
Marlene Fabiola Escobedo Monge ◽  
Enrique Barrado ◽  
Carmen Alonso Vicente ◽  
María Paz Redondo del Río ◽  
José Manuel Marugán de Miguelsanz
Keyword(s):  
Cystic Fibrosis ◽  
Nutritional Status ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Dietary Reference Intake ◽  
Human Beings ◽  
Z Score ◽  
Dietary Zinc ◽  
Zinc Intake ◽  
Marginal Zinc Deficiency

Background: Zinc is an essential nutrient for all forms of life and its deficiency affects the normal growth and development of human beings. Objective: The main aim was to investigate zinc nutritional status by serum zinc concentration (SZC) and dietary zinc intake and their association in cystic fibrosis (CF) patients. Methods: A cross-sectional study was conducted in CF patients. Anthropometric measurements and respiratory and pancreatic tests were conducted. Hypozincemia was determined by SZC while using atomic absorption spectrophotometry and dietary zinc deficiency by prospective 72-h dietary surveys. Results: Mean SZC (87.2 ± 16.7 μg/dL) and dietary zinc intake (97 ± 26.9% Dietary Reference Intake) were normal. Three of 17 patients with CF (17.6%) had hypozincemia and four (23.5%) had a dietary zinc deficiency. No patient with dietary zinc deficiency had hypozincemia. A positive and significant association was observed between SZC and Z-score of BMI-for-age (p = 0.048) and weight-for-height (p = 0.012) and between dietary zinc intake and energy intake (EI, p = 0.036) and Z-score of weight-for-high (p = 0.029). Conclusion: SZC was associated with the nutritional status, expressed as BMI (Body Mass Index) and weight-for-height Z score, and dietary zinc intake with EI and weight-for-height Z-score. No patient with hypozincemia had dietary zinc deficiency. This situation should alert us to a marginal zinc deficiency and it may explain why there were no overlapping cases between the two groups. We suggest that probably 41% of the cases in this study would be at elevated risk of zinc deficiency and a zinc supplementation may be considered.

scholarly journals Marginal Zinc Deficiency and Changes in Behavioral Salt Taste Threshold and Salt Preference in Mice.

1991 ◽  
Vol 37 (2) ◽  
pp. 185-199 ◽  
Author(s):  
Xing-Wang LIU ◽  
Yasushi DEJIMA ◽  
Tsuguyoshi SUZUKI ◽  
Sei-ichiro HIMENO ◽  
Yoichi OKAZAKI
Keyword(s):  
Zinc Deficiency ◽  
Taste Threshold ◽  
Salt Taste ◽  
Marginal Zinc Deficiency

Effects of maternal marginal zinc deficiency on myelin protein profiles in the suckling rat and infant rhesus monkey

1992 ◽  
Vol 34 (1) ◽  
pp. 55-66 ◽  
Author(s):  
Hueyjiuan Liu ◽  
Patricia I. Oteiza ◽  
M. Eric Gershwin ◽  
Mari S. Golub ◽  
Carl L. Keen
Keyword(s):  
Rhesus Monkey ◽  
Zinc Deficiency ◽  
Myelin Protein ◽  
Protein Profiles ◽  
Marginal Zinc Deficiency ◽  
Infant Rhesus

The Effects of Dietary Zinc Deficiency on Voluntary Alcohol Drinking in Rats

1984 ◽  
Vol 8 (6) ◽  
pp. 556-559 ◽  
Author(s):  
P. J. Collipp ◽  
V. K. Kris ◽  
M. Castro-Magana ◽  
A. Shih ◽  
S. Y. Chen ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Alcohol Drinking ◽  
Dietary Zinc

scholarly journals Supplementation with Bovine Milk or Soy Beverages Recovers Bone Mineralization in Young Growing Rats Fed an Insufficient Diet, in Contrast to an Almond Beverage

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Julie A Cakebread ◽  
Olivia A M Wallace ◽  
Marlena C Kruger ◽  
Mark H Vickers ◽  
Alison J Hodgkinson
Keyword(s):  
Amino Acids ◽  
Bone Density ◽  
Bone Mineralization ◽  
Bovine Milk ◽  
Biomechanical Properties ◽  
Intact Protein ◽  
Sprague Dawley ◽  
Uht Milk ◽  
Growing Rats ◽  
Sustainable Products

ABSTRACT Background Nondairy beverages, produced from soy, rice, oat, almond, or coconut, are increasingly being used as alternatives to dairy milk, with the perception that they are healthier and/or more sustainable products than dairy products. Objective The aim of this study was to compare the effects of supplementing either bovine milk, soy, or almond-based beverages to young, growing rats fed an intact-protein diet or a diet that had protein substituted with amino acids (AA-diet). Methods Three-week-old male Sprague-Dawley rats were randomly assigned to 5 groups (n = 10/group) and fed ad libitum for 4 wk. Two control groups were fed either standard AIN-93G food [20% casein (CN) protein] or AIN-93G with amino acids (AAs) equivalent to CN protein, and water to drink. Three treatment groups were fed AIN-93G AA and supplemented with either bovine ultra-heat treatment (UHT) milk or soy or almond UHT beverages. Rat weight gain and food intakes were recorded. During week 4, body composition was assessed using DEXA to determine lean soft tissue, fat, and bone mass. At trial end, bone biomechanical properties and blood plasma mineral concentrations were measured. Results At the end of the trial, animals supplemented with almond beverage were lightest (P > 0.05), with higher plasma calcium concentrations (P > 0.05) and lower bone mineral content (BMC) and bone density (P > 0.05) than animals supplemented with milk or soy beverage. Soy-supplemented animals had similar BMC and bone density compared with milk-supplemented animals, although the soy group gained most weight (P > 0.05) and had the highest fat:lean ratio (P > 0.05) compared with other groups. Conclusions In the model tested, supplementing rats with bovine UHT milk and soy UHT beverage provided favorable bone health outcomes. Conversely, almond UHT beverage was not an effective supplement and could be detrimental to bone mineralization and strength outcomes.

scholarly journals Secondary Zinc Deficiency via Exposure to the Environmental Toxicant Di-2-ethylhexyl phthalate Affects Neurogenesis at Embryonic Day 19

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1220-1220
Author(s):  
Xiuzhen Liu ◽  
Patricia Oteiza
Keyword(s):  
Brain Development ◽  
Zinc Deficiency ◽  
Zinc Concentration ◽  
Fetal Brain ◽  
Adult Brain ◽  
Acid Decarboxylase ◽  
Environmental Toxicants ◽  
Gestational Exposure ◽  
Marginal Zinc Deficiency ◽  
Ethylhexyl Phthalate

Abstract Objectives Zinc deficiency can affect early brain development. We previously found that developmental marginal zinc deficiency affected neurogenesis leading to a lower number of neurons and altered neural specification in the adult rat brain. Zinc deficiency can occur as low dietary zinc intake and secondary to diseases, infections, and exposure to environmental toxicants such as phthalates. This work investigated if gestational exposure to toxicant Di-2-ethylhexyl phthalate (DEHP) could decrease zinc availability to the fetus and altered neurogenesis. Methods Rats were fed an adequate (25 µg zinc/g diet) (C) or a marginal zinc deficient (MZD) (10 µg zinc/g diet), without or with DEHP (300 mg/kg BW) (C + DEHP, MZD + DEHP) from gestational day zero until embryonic day 19 (E19). Zinc concentration was analyzed by atomic absorption spectrometry (AAS). Neurogenesis was evaluated in the offspring at E19 measuring parameters of neural progenitor cells (NPC) proliferation and differentiation by Western blot and/or immunofluorescence. Results Fetal brain zinc concentration was significantly decreased in MZD, C + DEHP and MZD + DEHP than in C. Protein Markers of neurogenesis (NeuN, PAX6, SOX2, TBR2) were lower in MZD and C + DEHP than C, and lowest in MZD + DEHP. The excitatory neuron marker vesicular glutamate transporter 1 (VGLUT1) was lower in C + DEHP, MZD and MZD + DEHP than in C, while the marker of inhibitory neurons glutamic acid decarboxylase (GAD65) level were similar among groups. The ERK1/2 pathway, crucial to neurogenesis, was affected by MZD and DEHP. ERK1/2 activation was lower, and at a similar extent in C + DEHP and MZD groups than in C, while it was markedly lower in the MZD + DEHP group compared to all other groups. Lower ERK1/2 activation could be due to activation of the ERK1/2 phosphatase 2A (PP2A). We found that PP2A activation was higher, in MZD and DEHP than in C, being highest in the MZD + DEHP group. Conclusions Gestational exposure to DEHP in rats causes a secondary zinc deficiency in the fetal brain and altered neurogenesis. This can be due to the inhibition of the ERK1/2 signaling pathway. DEHP exposure can adversely affect the offspring's brain development and result in irreversible consequences to adult brain structure and function. Funding Sources Supported by grants from NIFA CA-D-XXX-7244-H, Packer-Wentz foundation, NIEHS T 32 training grant (T32 ES 0,07059).

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