Effects of maternal marginal zinc deficiency on myelin protein profiles in the suckling rat and infant rhesus monkey

1992 ◽  
Vol 34 (1) ◽  
pp. 55-66 ◽  
Author(s):  
Hueyjiuan Liu ◽  
Patricia I. Oteiza ◽  
M. Eric Gershwin ◽  
Mari S. Golub ◽  
Carl L. Keen
Keyword(s):  
Rhesus Monkey ◽  
Zinc Deficiency ◽  
Myelin Protein ◽  
Protein Profiles ◽  
Marginal Zinc Deficiency ◽  
Infant Rhesus

scholarly journals Marginal Zinc Deficiency and Changes in Behavioral Salt Taste Threshold and Salt Preference in Mice.

1991 ◽  
Vol 37 (2) ◽  
pp. 185-199 ◽  
Author(s):  
Xing-Wang LIU ◽  
Yasushi DEJIMA ◽  
Tsuguyoshi SUZUKI ◽  
Sei-ichiro HIMENO ◽  
Yoichi OKAZAKI
Keyword(s):  
Zinc Deficiency ◽  
Taste Threshold ◽  
Salt Taste ◽  
Marginal Zinc Deficiency

scholarly journals Secondary Zinc Deficiency via Exposure to the Environmental Toxicant Di-2-ethylhexyl phthalate Affects Neurogenesis at Embryonic Day 19

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1220-1220
Author(s):  
Xiuzhen Liu ◽  
Patricia Oteiza
Keyword(s):  
Brain Development ◽  
Zinc Deficiency ◽  
Zinc Concentration ◽  
Fetal Brain ◽  
Adult Brain ◽  
Acid Decarboxylase ◽  
Environmental Toxicants ◽  
Gestational Exposure ◽  
Marginal Zinc Deficiency ◽  
Ethylhexyl Phthalate

Abstract Objectives Zinc deficiency can affect early brain development. We previously found that developmental marginal zinc deficiency affected neurogenesis leading to a lower number of neurons and altered neural specification in the adult rat brain. Zinc deficiency can occur as low dietary zinc intake and secondary to diseases, infections, and exposure to environmental toxicants such as phthalates. This work investigated if gestational exposure to toxicant Di-2-ethylhexyl phthalate (DEHP) could decrease zinc availability to the fetus and altered neurogenesis. Methods Rats were fed an adequate (25 µg zinc/g diet) (C) or a marginal zinc deficient (MZD) (10 µg zinc/g diet), without or with DEHP (300 mg/kg BW) (C + DEHP, MZD + DEHP) from gestational day zero until embryonic day 19 (E19). Zinc concentration was analyzed by atomic absorption spectrometry (AAS). Neurogenesis was evaluated in the offspring at E19 measuring parameters of neural progenitor cells (NPC) proliferation and differentiation by Western blot and/or immunofluorescence. Results Fetal brain zinc concentration was significantly decreased in MZD, C + DEHP and MZD + DEHP than in C. Protein Markers of neurogenesis (NeuN, PAX6, SOX2, TBR2) were lower in MZD and C + DEHP than C, and lowest in MZD + DEHP. The excitatory neuron marker vesicular glutamate transporter 1 (VGLUT1) was lower in C + DEHP, MZD and MZD + DEHP than in C, while the marker of inhibitory neurons glutamic acid decarboxylase (GAD65) level were similar among groups. The ERK1/2 pathway, crucial to neurogenesis, was affected by MZD and DEHP. ERK1/2 activation was lower, and at a similar extent in C + DEHP and MZD groups than in C, while it was markedly lower in the MZD + DEHP group compared to all other groups. Lower ERK1/2 activation could be due to activation of the ERK1/2 phosphatase 2A (PP2A). We found that PP2A activation was higher, in MZD and DEHP than in C, being highest in the MZD + DEHP group. Conclusions Gestational exposure to DEHP in rats causes a secondary zinc deficiency in the fetal brain and altered neurogenesis. This can be due to the inhibition of the ERK1/2 signaling pathway. DEHP exposure can adversely affect the offspring's brain development and result in irreversible consequences to adult brain structure and function. Funding Sources Supported by grants from NIFA CA-D-XXX-7244-H, Packer-Wentz foundation, NIEHS T 32 training grant (T32 ES 0,07059).

Marginal Zinc Deficiency Negatively Affects Recovery from Muscle Injury in Mice

2014 ◽  
Vol 158 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Nobuko Jinno ◽  
Masashi Nagata ◽  
Takeshi Takahashi
Keyword(s):  
Zinc Deficiency ◽  
Muscle Injury ◽  
Marginal Zinc Deficiency

scholarly journals Challenges to maternal wellbeing during pregnancy impact temperament, attention, and neuromotor responses in the infant rhesus monkey

2010 ◽  
Vol 52 (7) ◽  
pp. 625-637 ◽  
Author(s):  
Christopher L. Coe ◽  
Gabriele R. Lubach ◽  
Heather R. Crispen ◽  
Elizabeth A. Shirtcliff ◽  
Mary L. Schneider
Keyword(s):  
Rhesus Monkey ◽  
Maternal Wellbeing ◽  
Infant Rhesus
Sign in / Sign up

Export Citation Format

Share Document