scholarly journals Interaction Between Functional Genetic Variation of DRD2 and Cannabis Use on Risk of Psychosis

2015 ◽  
Vol 41 (5) ◽  
pp. 1171-1182 ◽  
Author(s):  
Marco Colizzi ◽  
Conrad Iyegbe ◽  
John Powell ◽  
Gianluca Ursini ◽  
Annamaria Porcelli ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Cannabis Use ◽  
Functional Genetic Variation

scholarly journals Functional Genetic Variation of the Cannabinoid Receptor 1 and Cannabis Use Interact on Prefrontal Connectivity and Related Working Memory Behavior

2014 ◽  
Vol 40 (3) ◽  
pp. 640-649 ◽  
Author(s):  
Marco Colizzi ◽  
Leonardo Fazio ◽  
Laura Ferranti ◽  
Annamaria Porcelli ◽  
Rita Masellis ◽  
...  
Keyword(s):  
Working Memory ◽  
Genetic Variation ◽  
Cannabinoid Receptor ◽  
Cannabis Use ◽  
Cannabinoid Receptor 1 ◽  
Functional Genetic Variation

scholarly journals Functional genetic variation in the Rev-Erbαpathway and lithium response in the treatment of bipolar disorder

2011 ◽  
Vol 10 (8) ◽  
pp. 852-861 ◽  
Author(s):  
M. J. McCarthy ◽  
C. M. Nievergelt ◽  
T. Shekhtman ◽  
D. F. Kripke ◽  
D. K. Welsh ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Genetic Variation ◽  
Functional Genetic Variation ◽  
Lithium Response

scholarly journals The crucial role of genome-wide genetic variation in conservation

2021 ◽  
Vol 118 (48) ◽  
pp. e2104642118
Author(s):  
Marty Kardos ◽  
Ellie E. Armstrong ◽  
Sarah W. Fitzpatrick ◽  
Samantha Hauser ◽  
Philip W. Hedrick ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Environmental Changes ◽  
Population Viability ◽  
Adaptive Potential ◽  
Biodiversity Crisis ◽  
Genome Wide ◽  
Simulation Based ◽  
Functional Genetic Variation

The unprecedented rate of extinction calls for efficient use of genetics to help conserve biodiversity. Several recent genomic and simulation-based studies have argued that the field of conservation biology has placed too much focus on conserving genome-wide genetic variation, and that the field should instead focus on managing the subset of functional genetic variation that is thought to affect fitness. Here, we critically evaluate the feasibility and likely benefits of this approach in conservation. We find that population genetics theory and empirical results show that conserving genome-wide genetic variation is generally the best approach to prevent inbreeding depression and loss of adaptive potential from driving populations toward extinction. Focusing conservation efforts on presumably functional genetic variation will only be feasible occasionally, often misleading, and counterproductive when prioritized over genome-wide genetic variation. Given the increasing rate of habitat loss and other environmental changes, failure to recognize the detrimental effects of lost genome-wide genetic variation on long-term population viability will only worsen the biodiversity crisis.

scholarly journals Functional Genetic Variation in NFKBIA and Susceptibility to Childhood Asthma, Bronchiolitis, and Bronchopulmonary Dysplasia

2013 ◽  
Vol 190 (8) ◽  
pp. 3949-3958 ◽  
Author(s):  
Salman Ali ◽  
Aaron F. Hirschfeld ◽  
Matthew L. Mayer ◽  
Edgardo S. Fortuno ◽  
Nathan Corbett ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Bronchopulmonary Dysplasia ◽  
Childhood Asthma ◽  
Functional Genetic Variation

scholarly journals Natural selection and functional genetic variation in the p53 pathway

2011 ◽  
Vol 20 (8) ◽  
pp. 1502-1508 ◽  
Author(s):  
Lara Sucheston ◽  
David B. Witonsky ◽  
Darcie Hastings ◽  
Ozlem Yildiz ◽  
Vanessa J. Clark ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Natural Selection ◽  
P53 Pathway ◽  
Functional Genetic Variation

scholarly journals Neural correlates of inhibitory control and functional genetic variation in the dopamine D4 receptor gene

2014 ◽  
Vol 62 ◽  
pp. 306-318 ◽  
Author(s):  
Richard C. Mulligan ◽  
Sean D. Kristjansson ◽  
Angela M. Reiersen ◽  
Andres S. Parra ◽  
Andrey P. Anokhin
Keyword(s):  
Genetic Variation ◽  
Inhibitory Control ◽  
Receptor Gene ◽  
Neural Correlates ◽  
Dopamine D4 Receptor ◽  
Functional Genetic Variation ◽  
D4 Receptor

Influence of adaptive evolution of cadmium tolerance on neutral and functional genetic variation in Orchesella cincta

Ecotoxicology ◽  
2012 ◽  
Vol 21 (7) ◽  
pp. 2078-2087 ◽  
Author(s):  
Dalila Costa ◽  
Janine Mariën ◽  
Thierry K. S. Janssens ◽  
Cornelis A. M. van Gestel ◽  
Gerard Driessen ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Adaptive Evolution ◽  
Cadmium Tolerance ◽  
Orchesella Cincta ◽  
Functional Genetic Variation

scholarly journals Identification of functional genetic variation in exome sequence analysis

2011 ◽  
Vol 5 (S9) ◽  
Author(s):  
Andrew Jaffe ◽  
Genevieve Wojcik ◽  
Audrey Chu ◽  
Asieh Golozar ◽  
Ankit Maroo ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Sequence Analysis ◽  
Functional Genetic Variation ◽  
Exome Sequence
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