scholarly journals Functional Genetic Variation of the Cannabinoid Receptor 1 and Cannabis Use Interact on Prefrontal Connectivity and Related Working Memory Behavior

2014 ◽  
Vol 40 (3) ◽  
pp. 640-649 ◽  
Author(s):  
Marco Colizzi ◽  
Leonardo Fazio ◽  
Laura Ferranti ◽  
Annamaria Porcelli ◽  
Rita Masellis ◽  
...  
Keyword(s):  
Working Memory ◽  
Genetic Variation ◽  
Cannabinoid Receptor ◽  
Cannabis Use ◽  
Cannabinoid Receptor 1 ◽  
Functional Genetic Variation

scholarly journals Allele-dosage genetic polymorphisms of cannabinoid receptor 1 predict attention, but not working memory performance in humans

2021 ◽  
Vol 216 ◽  
pp. 103299
Author(s):  
Elsa Ivett Ortega-Mora ◽  
Ulises Caballero-Sánchez ◽  
Talía V. Román-López ◽  
Cintia B. Rosas-Escobar ◽  
Juan Antonio González-Barrios ◽  
...  
Keyword(s):  
Working Memory ◽  
Genetic Polymorphisms ◽  
Cannabinoid Receptor ◽  
Memory Performance ◽  
Cannabinoid Receptor 1 ◽  
Allele Dosage

Association of functional genetic variation in PP2A with prefrontal working memory processing

2017 ◽  
Vol 316 ◽  
pp. 125-130 ◽  
Author(s):  
Antonio Rampino ◽  
Pasquale Di Carlo ◽  
Leonardo Fazio ◽  
Gianluca Ursini ◽  
Giulio Pergola ◽  
...  
Keyword(s):  
Working Memory ◽  
Genetic Variation ◽  
Memory Processing ◽  
Functional Genetic Variation

scholarly journals Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice

2020 ◽  
Vol 6 (7) ◽  
pp. eaay1502 ◽  
Author(s):  
Caitlin E. Burgdorf ◽  
Deqiang Jing ◽  
Ruirong Yang ◽  
Chienchun Huang ◽  
Matthew N. Hill ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Cannabinoid Receptor ◽  
Endocannabinoid System ◽  
Adolescent Female ◽  
Cannabinoid Receptor 1 ◽  
Reward Circuitry ◽  
Female Mice ◽  
Problematic Drug ◽  
Human Polymorphism ◽  
Increased Susceptibility

Adolescence represents a developmental period with the highest risk for initiating cannabis use. Little is known about whether genetic variation in the endocannabinoid system alters mesolimbic reward circuitry to produce vulnerability to the rewarding properties of the exogenous cannabinoid Δ9-tetrahydrocannabinol (THC). Using a genetic knock-in mouse model (FAAHC/A) that biologically recapitulates the human polymorphism associated with problematic drug use, we find that in adolescent female mice, but not male mice, this FAAH polymorphism enhances the mesolimbic dopamine circuitry projecting from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) and alters cannabinoid receptor 1 (CB1R) levels at inhibitory and excitatory terminals in the VTA. These developmental changes collectively increase vulnerability of adolescent female FAAHC/A mice to THC preference that persists into adulthood. Together, these findings suggest that this endocannabinoid genetic variant is a contributing factor for increased susceptibility to cannabis dependence in adolescent females.

scholarly journals Cannabinoid Receptor 1 Gene by Cannabis Use Interaction on CB1 Receptor Density

2017 ◽  
Vol 2 (1) ◽  
pp. 202-209 ◽  
Author(s):  
Ariel Ketcherside ◽  
Lindsey J. Noble ◽  
Christa K. McIntyre ◽  
Francesca M. Filbey
Keyword(s):  
Cannabinoid Receptor ◽  
Cb1 Receptor ◽  
Cannabis Use ◽  
Receptor Density ◽  
Cannabinoid Receptor 1

A variant on promoter of the cannabinoid receptor 1 gene (CNR1) moderates the effect of valence on working memory

Memory ◽  
2017 ◽  
Vol 26 (2) ◽  
pp. 260-268 ◽  
Author(s):  
Beth Fairfield ◽  
Nicola Mammarella ◽  
Marica Franzago ◽  
Alberto Di Domenico ◽  
Liborio Stuppia ◽  
...  
Keyword(s):  
Working Memory ◽  
Cannabinoid Receptor ◽  
Cannabinoid Receptor 1

scholarly journals Interaction Between Functional Genetic Variation of DRD2 and Cannabis Use on Risk of Psychosis

2015 ◽  
Vol 41 (5) ◽  
pp. 1171-1182 ◽  
Author(s):  
Marco Colizzi ◽  
Conrad Iyegbe ◽  
John Powell ◽  
Gianluca Ursini ◽  
Annamaria Porcelli ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Cannabis Use ◽  
Functional Genetic Variation

scholarly journals Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index

2008 ◽  
Vol 9 (11) ◽  
pp. 1647-1656 ◽  
Author(s):  
Tes M Baye ◽  
Yi Zhang ◽  
Edward Smith ◽  
Cecilia J Hillard ◽  
Jennifer Gunnell ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Genetic Variation ◽  
Body Mass ◽  
Cannabinoid Receptor ◽  
Lipid Homeostasis ◽  
Cannabinoid Receptor 1
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