scholarly journals Functional Genetic Variation in NFKBIA and Susceptibility to Childhood Asthma, Bronchiolitis, and Bronchopulmonary Dysplasia

2013 ◽  
Vol 190 (8) ◽  
pp. 3949-3958 ◽  
Author(s):  
Salman Ali ◽  
Aaron F. Hirschfeld ◽  
Matthew L. Mayer ◽  
Edgardo S. Fortuno ◽  
Nathan Corbett ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Bronchopulmonary Dysplasia ◽  
Childhood Asthma ◽  
Functional Genetic Variation

scholarly journals Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma

2009 ◽  
Vol 10 (1) ◽  
Author(s):  
Benjamin A Raby ◽  
Kristel Van Steen ◽  
Jessica Lasky-Su ◽  
Kelan Tantisira ◽  
Feige Kaplan ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Childhood Asthma ◽  
Airway Responsiveness

scholarly journals Functional genetic variation in the Rev-Erbαpathway and lithium response in the treatment of bipolar disorder

2011 ◽  
Vol 10 (8) ◽  
pp. 852-861 ◽  
Author(s):  
M. J. McCarthy ◽  
C. M. Nievergelt ◽  
T. Shekhtman ◽  
D. F. Kripke ◽  
D. K. Welsh ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Genetic Variation ◽  
Functional Genetic Variation ◽  
Lithium Response

scholarly journals Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma

2007 ◽  
Vol 120 (2) ◽  
pp. 322-328 ◽  
Author(s):  
Hao Wu ◽  
Isabelle Romieu ◽  
Juan-Jose Sienra-Monge ◽  
Blanca Estela del Rio-Navarro ◽  
Daniel M. Anderson ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Childhood Asthma

scholarly journals The crucial role of genome-wide genetic variation in conservation

2021 ◽  
Vol 118 (48) ◽  
pp. e2104642118
Author(s):  
Marty Kardos ◽  
Ellie E. Armstrong ◽  
Sarah W. Fitzpatrick ◽  
Samantha Hauser ◽  
Philip W. Hedrick ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Environmental Changes ◽  
Population Viability ◽  
Adaptive Potential ◽  
Biodiversity Crisis ◽  
Genome Wide ◽  
Simulation Based ◽  
Functional Genetic Variation

The unprecedented rate of extinction calls for efficient use of genetics to help conserve biodiversity. Several recent genomic and simulation-based studies have argued that the field of conservation biology has placed too much focus on conserving genome-wide genetic variation, and that the field should instead focus on managing the subset of functional genetic variation that is thought to affect fitness. Here, we critically evaluate the feasibility and likely benefits of this approach in conservation. We find that population genetics theory and empirical results show that conserving genome-wide genetic variation is generally the best approach to prevent inbreeding depression and loss of adaptive potential from driving populations toward extinction. Focusing conservation efforts on presumably functional genetic variation will only be feasible occasionally, often misleading, and counterproductive when prioritized over genome-wide genetic variation. Given the increasing rate of habitat loss and other environmental changes, failure to recognize the detrimental effects of lost genome-wide genetic variation on long-term population viability will only worsen the biodiversity crisis.

scholarly journals Natural selection and functional genetic variation in the p53 pathway

2011 ◽  
Vol 20 (8) ◽  
pp. 1502-1508 ◽  
Author(s):  
Lara Sucheston ◽  
David B. Witonsky ◽  
Darcie Hastings ◽  
Ozlem Yildiz ◽  
Vanessa J. Clark ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Natural Selection ◽  
P53 Pathway ◽  
Functional Genetic Variation

scholarly journals Neural correlates of inhibitory control and functional genetic variation in the dopamine D4 receptor gene

2014 ◽  
Vol 62 ◽  
pp. 306-318 ◽  
Author(s):  
Richard C. Mulligan ◽  
Sean D. Kristjansson ◽  
Angela M. Reiersen ◽  
Andres S. Parra ◽  
Andrey P. Anokhin
Keyword(s):  
Genetic Variation ◽  
Inhibitory Control ◽  
Receptor Gene ◽  
Neural Correlates ◽  
Dopamine D4 Receptor ◽  
Functional Genetic Variation ◽  
D4 Receptor

Genetic variation in uncontrolled childhood asthma despite ICS treatment

2015 ◽  
Vol 16 (2) ◽  
pp. 158-163 ◽  
Author(s):  
M Leusink ◽  
S J H Vijverberg ◽  
L Koenderman ◽  
J A M Raaijmakers ◽  
J C de Jongste ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Childhood Asthma
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