TWO FACTORS INFLUENCING DOSE RECONSTRUCTION IN LOW DOSE RANGE: THE VARIABILITY OF BKG INTENSITY ON ONE INDIVIDUAL AND WATER CONTENT

2015 ◽  
pp. ncv382 ◽  
Author(s):  
Tengda Zhang ◽  
Wenyi Zhang ◽  
Zhixin Zhao ◽  
Haiying Zhang ◽  
Shuzhou Ruan ◽  
...  
1984 ◽  
Vol 52 (03) ◽  
pp. 347-349 ◽  
Author(s):  
Daan W Traas ◽  
Bep Hoegee-de Nobel ◽  
Willem Nieuwenhuizen

SummaryNative human plasminogen, the proenzyme of plasmin (E. C. 3.4.21.7) occurs in blood in two well defined forms, affinity forms I and II. In this paper, the feasibility of separating these forms of human native plasminogen by affinity chromatography, is shown to be dependent on two factors: 1) the ionic composition of the buffer containing the displacing agent: buffers of varying contents of sodium, Tris, phosphate and chloride ions were compared, and 2) the type of adsorbent. Two adsorbents were compared: Sepharose-lysine and Sepharose-bisoxirane-lysine. Only in the phosphate containing buffers, irrespective of the type of adsorbent, the affinity forms can be separated. The influence of the adsorbent can be accounted for by a large difference in dissociation constants of the complex between plasminogen and the immobilized lysine.


1960 ◽  
Vol XXXV (II) ◽  
pp. 245-252 ◽  
Author(s):  
G. P. van Rees ◽  
F. J. A. Paesi

ABSTRACT In the experiments reported in this paper the hypothesis that the decrease in the pituitary I. C. S. H.-content, which occurs after administration of steroid sex hormones in gonadectomized animals, is counteracted by a reflex stimulation of the hypophysis initiated by the operation has been investigated. If treatment with a low dose of testosterone propionate (100 μg) was started immediately after castration, the resulting decrease in the pituitary I. C. S. H.-content became more marked if the reflex stimulation of the hypophysis had been prevented. If, however, two months were allowed to elapse before the beginning of treatment, the presence or absence of this reflex was no longer of importance for the effect of testosterone propionate on the pituitary I. C. S. H.-content. And yet, in this case too, the decrease in the pituitary I. C. S. H.-content by testosterone propionate was less than in intact animals (see preceding paper). Hence this decrease appears to be counteracted by two factors: one rapidly occurring and short lasting, resulting from a reflex elicited by gonadectomy; the other gradually increasing in potency and possibly a direct consequence of the continued absence of pituitary inhibiting sex steroids.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Gertraud Eylert ◽  
Reinhard Dolp ◽  
Alexandra Parousis ◽  
Richard Cheng ◽  
Christopher Auger ◽  
...  

Abstract Background Multipotent mesenchymal stromal/stem cell (MSC) therapy is under investigation in promising (pre-)clinical trials for wound healing, which is crucial for survival; however, the optimal cell dosage remains unknown. The aim was to investigate the efficacy of different low-to-high MSC dosages incorporated in a biodegradable collagen-based dermal regeneration template (DRT) Integra®. Methods We conducted a porcine study (N = 8 Yorkshire pigs) and seeded between 200 and 2,000,000 cells/cm2 of umbilical cord mesenchymal stromal/stem cells on the DRT and grafted it onto full-thickness burn excised wounds. On day 28, comparisons were made between the different low-to-high cell dose groups, the acellular control, a burn wound, and healthy skin. Result We found that the low dose range between 200 and 40,000 cells/cm2 regenerates the full-thickness burn excised wounds most efficaciously, followed by the middle dose range of 200,000–400,000 cells/cm2 and a high dose of 2,000,000 cells/cm2. The low dose of 40,000 cells/cm2 accelerated reepithelialization, reduced scarring, regenerated epidermal thickness superiorly, enhanced neovascularization, reduced fibrosis, and reduced type 1 and type 2 macrophages compared to other cell dosages and the acellular control. Conclusion This regenerative cell therapy study using MSCs shows efficacy toward a low dose, which changes the paradigm that more cells lead to better wound healing outcome.


1989 ◽  
Vol 50 (C6) ◽  
pp. C6-174-C6-174
Author(s):  
M. VALENZA ◽  
P. GIRARD ◽  
B. PISTOULET
Keyword(s):  
Low Dose ◽  

2016 ◽  
Vol 8 (1) ◽  
pp. 24-28
Author(s):  
Maya Indra Rasyid

(Chemical and Organoleptic Characteristics of Mung Bean Flakes with The Addition of Fillers and Water) ABSTRACT. The objective of this research was to determine the chemical and organoleptic characteristics of mung bean flakes with the addition of fillers and water. The study was conducted using completely randomized design with two factors namely the addition of fillers and water. The results showed that the addition of fillers and water has significant (P≤0,01) effect on the water absorption ratio and protein levels of mung bean flakes. The best treatment was obtained by the mung bean flour without the addition of fillers with 150% of addition water with water absorption ratio of 204%, water content of 5,7%, protein of 22,01%, starch levels of 61,76%, organoleptic values of aroma of 2,61, color of 2,42, crispness of 2,72 and flavor of 2,83.


2021 ◽  
Author(s):  
Kathryn Harper

The present research investigated the role of perceived threat to freedom of choice in children’s development of preference for scarcity. In two experiments, 5- to 7-year-olds assisted a fictional agent in choosing between relatively scarce versus abundant toys in a “virtual shop.” Experiment 1 investigated the role of extremity of scarcity in children’s preference for scarcity, while Experiment 2 investigated the role of the presence of competition. These two factors were anticipated to activate perceived threat to freedom to choose the scarce objects, resulting in motivational arousal to choose the scarce objects. Overall, a preference for scarcity increased with age. When threat to freedom of choice was induced, 7-year-olds showed a robust preference for scarcity in both experiments. The findings are discussed in the context of reactance theory and other factors influencing children’s patterns of responses, including prosociality. This research contributes to our understanding of children’s use of statistical information. Key words: scarcity, threat to freedom of choice, psychological reactance


2018 ◽  
Vol 69 (04) ◽  
pp. 338-344
Author(s):  
SIMION CEZAR-PETRE ◽  
ALEXANDRU ADRIANA ◽  
CEPTUREANU SEBASTIAN ION ◽  
CEPTUREANU EDUARD GABRIEL

In this paper the main factors that influence the innovative projects in the field of textiles, wearing apparel, leather and related products were identified and analyzed. Eleven potential factors influencing innovative projects have been considered and the correlation analysis has identified the two factors that have a major influence on innovative projects in the field: volume index of production in European Union for NACE codes 13-15 and exports value for textiles, wearing apparel, leather and related products. The research has shown that the scale of innovative projects in textiles, clothing, leather and related products depends on European Union production and on global demand.


2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Rosdalina Bukido

The research on "PARADIGM AND REALITY OF LAW ENFORCEMENT IN INDONESIA" is a library research, which aims to investigate about the factors influencing failed law enforcement in Indonesia. The good law enforcement is one of the criterions success nation to increase the dignity specially in law. Law should protect all societies living anywhere. So, it can create stability and safety life of our societies. There are many functions of law. Law can make the good thing for all sectors, for example economic, politic, trade, etc. Paradigm and reality of law enforcement in Indonesia is not carried out well yet. It is caused by two factors. They are officers of law enforcement (judge, police, advocate, and public prosecutor). If they have the good morality and integrity, law enforcement can run well. The second is Indonesian legislative assembly as the makers of law. Although the makers of law are not socialization with societies directly, but the result of them can reach and cover all problems in Indonesian societies. 


2021 ◽  
Vol 9 (2) ◽  
pp. 73-82
Author(s):  
Anisa Leksono ◽  
◽  
Erni Sofia Murtini ◽  

Aquilaria is one of the plant genus-producing agarwood. Aquilaria leaves have pharmacological effects which the potential to be processed into black tea. The aim of this study is to determine the effect of fermentation duration on physicochemical and organoleptic characteristics of Aquilaria leaves tea. This study employed a Completely Randomized Design with two factors; the plant species (A. crassna, A. malaccensis, and A. subintegra) and fermentation duration (0 minutes, 70 minutes, and 90 minutes). Parameters analyzed including water content, total phenol, and antioxidant activity. Organoleptic tests were performed on the color, taste, and aroma of the brewed tea. The results summarized that A. subintegra had the highest total phenol and antioxidant activity, but the taste of the tea was not favored. A. crassna fermented 70 minutes and A. malaccensis fermented 0 minutes were the most preferred, but both have lower total phenol and antioxidant activity than A. subintegra.


2009 ◽  
Vol 23 (1) ◽  
pp. 97-118 ◽  
Author(s):  
Diane Janvrin ◽  
James Bierstaker ◽  
D. Jordan Lowe

ABSTRACT: We provide data on the extent to which computer-related audit procedures are used and whether two factors, control risk assessment and audit firm size, influence computer-related audit procedures use. We used a field-based questionnaire to collect data from 181 auditors representing Big 4, national, regional, and local firms. Results indicate that computer-related audit procedures are generally used when obtaining an understanding of the client system and business processes and testing computer controls. Furthermore, 42.9 percent of participants indicate that they relied on internal controls; however, this percentage increases significantly for auditors at Big 4 firms. Finally, our results raise questions for future research regarding computer-related audit procedure use.


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