scholarly journals Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release

2014 ◽  
Vol 1 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Teng-Teng Cai ◽  
Qi Lei ◽  
Bin Yang ◽  
Hui-Zhen Jia ◽  
Hong Cheng ◽  
...  
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Ph Responsive ◽  
Bond Interaction ◽  
Loading Efficiency

scholarly journals A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release

2018 ◽  
Vol 9 (29) ◽  
pp. 4063-4072 ◽  
Author(s):  
Yan Chen ◽  
Yuting Gao ◽  
Lucília P. da Silva ◽  
Rogério P. Pirraco ◽  
Mengdi Ma ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Drug Release ◽  
Sustained Release ◽  
Small Molecule ◽  
Drug Carrier ◽  
Ph Responsive ◽  
General Drug ◽  
Model Drug ◽  
Molecule Model ◽  
Responsive Hydrogels

The aim of this research was to develop thermo- and pH-responsive hydrogels based on H-bonds for the sustained release of the small-molecule model drug Methylene Blue (MB).

pH-responsive cancer-targeted selenium nanoparticles: a transformable drug carrier with enhanced theranostic effects

2014 ◽  
Vol 2 (33) ◽  
pp. 5409-5418 ◽  
Author(s):  
Bo Yu ◽  
Xiaoling Li ◽  
Wenjie Zheng ◽  
Yanxian Feng ◽  
Yum-Shing Wong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Cell Organelles ◽  
Shape Transformation ◽  
Anticancer Efficacy

A cancer-targeted and structure-transformable drug delivery system has been constructed, which displays enhanced anticancer efficacy and exhibits the characteristics of shape transformation and pH-controlled drug release under acidifying cell organelles.

Aggregates of silicon quantum dots as a drug carrier: selective intracellular drug release based on pH-responsive aggregation/dispersion

2015 ◽  
Vol 51 (29) ◽  
pp. 6422-6425 ◽  
Author(s):  
Seiichi Ohta ◽  
Kentaro Yamura ◽  
Susumu Inasawa ◽  
Yukio Yamaguchi
Keyword(s):  
Quantum Dots ◽  
Drug Release ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Silicon Quantum Dots ◽  
Release System ◽  
Drug Release System

A novel, controlled drug-release system was developed based on aggregation/dispersion of silicon quantum dots (Si-QDs) in response to a change in the pH environment.

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy

Biomaterials ◽  
2018 ◽  
Vol 154 ◽  
pp. 169-181 ◽  
Author(s):  
Yanan Tan ◽  
Yun Zhu ◽  
Yue Zhao ◽  
Lijuan Wen ◽  
Tingting Meng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Alkaline Ph ◽  
Ph Responsive

Preparation of pH ‐responsive cellulose nanofibril/sodium alginate based hydrogels for drug release

2021 ◽  
pp. 51647
Author(s):  
Yuhang Li ◽  
Cong Wang ◽  
Yunhao Luan ◽  
Wanyi Liu ◽  
Tiantian Chen ◽  
...  
Keyword(s):  
Drug Release ◽  
Sodium Alginate ◽  
Cellulose Nanofibril ◽  
Ph Responsive

Dual pH-responsive micelles with both charge-conversional property and hydrophobic–hydrophilic transition for effective cellular uptake and intracellular drug release

2016 ◽  
Vol 7 (12) ◽  
pp. 2202-2208 ◽  
Author(s):  
Shuai Li ◽  
Zhouxiang Zhao ◽  
Wei Wu ◽  
Chunmei Ding ◽  
Jianshu Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cellular Uptake ◽  
Diblock Copolymers ◽  
Effective Drug ◽  
Ph Responsive ◽  
A Charge

Two types of diblock copolymers are synthesized to construct dual pH-responsive micelles with a charge-conversional property for effective drug delivery.

pH-Responsive Nanoscale Covalent Organic Polymers as a Biodegradable Drug Carrier for Combined Photodynamic Chemotherapy of Cancer

2018 ◽  
Vol 10 (17) ◽  
pp. 14475-14482 ◽  
Author(s):  
Hairong Wang ◽  
Wenwen Zhu ◽  
Jingjing Liu ◽  
Ziliang Dong ◽  
Zhuang Liu
Keyword(s):  
Drug Carrier ◽  
Organic Polymers ◽  
Ph Responsive
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