scholarly journals A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release

2018 ◽  
Vol 9 (29) ◽  
pp. 4063-4072 ◽  
Author(s):  
Yan Chen ◽  
Yuting Gao ◽  
Lucília P. da Silva ◽  
Rogério P. Pirraco ◽  
Mengdi Ma ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Drug Release ◽  
Sustained Release ◽  
Small Molecule ◽  
Drug Carrier ◽  
Ph Responsive ◽  
General Drug ◽  
Model Drug ◽  
Molecule Model ◽  
Responsive Hydrogels

The aim of this research was to develop thermo- and pH-responsive hydrogels based on H-bonds for the sustained release of the small-molecule model drug Methylene Blue (MB).

scholarly journals Semi-Crystalline Copolymer Hydrogels as Smart Drug Carriers: In Vitro Thermo-Responsive Naproxen Release Study

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 158
Author(s):  
Snežana Ilić-Stojanović ◽  
Ljubiša Nikolić ◽  
Vesna Nikolić ◽  
Slobodan Petrović ◽  
Violeta Oro ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Drug Carriers ◽  
Xrd Analysis ◽  
Hplc Method ◽  
Potential Candidate ◽  
Swelling Kinetic ◽  
Model Drug ◽  
Xrd Techniques ◽  
Responsive Hydrogels

In this study, poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate) hydrogels were synthesized using free radical initiated copolymerization method. Four hydrogels with different cross-linker concentrations were prepared. Semi-crystalline, cross-linked copolymer networks were confirmed by FTIR, SEM and XRD analysis. Variation of swelling behaviour was monitored gravimetrically and thermo-responsiveness has been noticed. An application of synthesized thermo-responsive hydrogels as carriers for the modulated release of anti-inflammatory model drug was investigated. Moreover, naproxen loading into these hydrogels was also determined using FTIR, SEM and XRD techniques and release was analyzed using HPLC method at simulated physiological conditions. Swelling kinetic and mechanism of water transport, as well as diffusion of naproxen through the hydrogels were analyzed. Thus, the aim of this work was to study various compositions of obtained hydrogels and their possibility of application as a thermo-responsive carrier for prolonged naproxen release in order to evaluate as a potential candidate for drug carrier in future pharmaceutical applications.

scholarly journals Highly deformable hydrogels constructed by pH-triggered polyacid nanoparticle disassembly in aqueous dispersions

Soft Matter ◽  
2018 ◽  
Vol 14 (18) ◽  
pp. 3510-3520 ◽  
Author(s):  
Wenkai Wang ◽  
Dongdong Lu ◽  
Mingning Zhu ◽  
Jennifer M. Saunders ◽  
Amir H. Milani ◽  
...  
Keyword(s):  
Small Molecule ◽  
Building Blocks ◽  
Polymer Nanoparticles ◽  
Ph Responsive ◽  
Aqueous Dispersions ◽  
Responsive Hydrogels

We study remarkably deformable and resilient pH-responsive hydrogels constructed using crosslinker-free polymer nanoparticles as the only gel building blocks in the absence of added small molecule monomers.

Thermally Responsive Hydrogel Blends: A General Drug Carrier Model for Controlled Drug Release

2015 ◽  
Vol 54 (25) ◽  
pp. 7376-7380 ◽  
Author(s):  
Chongbo Ma ◽  
Ye Shi ◽  
Danilo A. Pena ◽  
Lele Peng ◽  
Guihua Yu
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Carrier Model ◽  
Thermally Responsive ◽  
General Drug

Photo-cross-linked biodegradable thermo- and pH-responsive hydrogels for controlled drug release

2011 ◽  
Vol 123 (5) ◽  
pp. 2923-2932 ◽  
Author(s):  
Changwen Zhao ◽  
Pan He ◽  
Chunsheng Xiao ◽  
Xiaoye Gao ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Responsive Hydrogels

Thermally Responsive Hydrogel Blends: A General Drug Carrier Model for Controlled Drug Release

2015 ◽  
Vol 127 (25) ◽  
pp. 7484-7488 ◽  
Author(s):  
Chongbo Ma ◽  
Ye Shi ◽  
Danilo A. Pena ◽  
Lele Peng ◽  
Guihua Yu
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Carrier Model ◽  
Thermally Responsive ◽  
General Drug

scholarly journals Fabrication and performance of a spherical cellulose nanocrystal-based hydrophobic drug delivery vehicle using rubber wood

BioResources ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. 7763-7774
Author(s):  
Dingyuan Zheng ◽  
Yating Deng ◽  
Yue Xia ◽  
Yiman Nan ◽  
Meijiao Peng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Carrier ◽  
Raw Material ◽  
Release Mechanism ◽  
Ammonium Bromide ◽  
Hydrophobic Drug ◽  
Rubber Wood ◽  
Model Drug ◽  
And Performance

Cellulose nanocrystals (CNCs) were fabricated using rubber wood (RW) as the raw material via acid hydrolysis followed by ultrasonication. The CNCs samples were then grafted with succinic anhydride to obtain modified CNCs, hereafter called CS. The CS samples were subsequently coated with a cationic surfactant, cetyltrimethyl ammonium bromide, and the obtained samples were named as CC. The morphology, chemical structure, and thermal stability of the RW, CNCs, CS, and CC samples were characterized using transmission electron microscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis, respectively. Finally, the drug release performance was investigated using CC as the drug carrier and hesperidin, a hydrophobic drug, as the model drug. The drug release mechanism was also considered. The results of this study identified a new route for the high-value utilization of RW and also demonstrated that RW could be used as a novel substrate for the construction of cellulose-based hydrophobic drug delivery systems.

scholarly journals Smart Microneedles with Porous Polymer Coatings for pH-Responsive Drug Delivery

Polymers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1834 ◽  
Author(s):  
Ullah ◽  
Khan ◽  
Choi ◽  
Kim
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Sodium Bicarbonate ◽  
Porous Polymer ◽  
Polymer Layer ◽  
Ph Responsive ◽  
Acidic Microenvironment ◽  
Model Drug

: This work demonstrates a simple approach for coating a porous polymer layer on stainless-steel (SS) microneedles characterized by a pH-responsive formulation for self-regulated drug delivery. For many drug-delivery applications, the release of therapeutic agents in an acidic microenvironment is desirable. Acid-sensitive polymers and hydrogels were extensively explored, but easily prepared polymeric microcarriers that combine acid sensitivity and biodegradability are rare. Here, we describe a simple and robust method of coating a porous polymer layer on SS microneedles (MNs) that release a model drug (lidocaine) in a pH-responsive fashion. It was constructed by packing the model drug and a pH-sensitive component (sodium bicarbonate) into the pores of the polymer layer. When this acid-sensitive formulation was exposed to the acidic microenvironment, the consequent reaction of protons (H+) with sodium bicarbonate (NaHCO3) yielded CO2. This effect generated pressure inside the pores of the coating and ruptured the thin polymer membrane, thereby releasing the encapsulated drug. Scanning electron micrographs showed that the pH-sensitive porous polymer-coated MNs exposed to phosphate-buffered saline (PBS) at pH 7.4 were characterized by closed pores. However, MNs exposed to PBS at pH 5.5 consisted of open pores and the thin membrane burst. The in vitro studies demonstrated the pH sensitivity of the drug release from porous polymer-coated MNs. Negligible release was observed for MNs in receiving media at pH 7.4. In contrast, significant release occurred when the MNs were exposed to acidic conditions (pH 5.5). Additionally, comparable results were obtained for drug release in vitro in porcine skin and in PBS. This revealed that our developed pH-responsive porous polymer-coated MNs could potentially be used for the controlled release of drug formulations in an acidic environment. Moreover, the stimuli-responsive drug carriers will enable on-demand controlled release profiles that may enhance therapeutic effectiveness and reduce systemic toxicity.

Synthesis of Chitosan-Polyvinyl Alcohol Copolymers for Smart Drug Delivery Application

2017 ◽  
Vol 25 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Neha Mulchandani ◽  
Nimish Shah ◽  
Tejal Mehta
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Polyvinyl Alcohol ◽  
Morphological Changes ◽  
Crosslinking Agent ◽  
Ph Responsive ◽  
Thermal Transitions ◽  
Scanning Calorimetry ◽  
Model Drug

Chitosan is a natural polymer obtained from exoskeletons of crustaceans and polyvinyl alcohol (PVA) is a synthetic polymer which has excellent film forming ability along with non-toxic nature. The current work focuses on synthesizing a smart polymer by copolymerization of natural and synthetic polymers and exploring its applications in drug delivery. The copolymers were blended in different ratios and were synthesized using ammonium ceric nitrate as initiator and glutaraldehyde as a crosslinking agent which were converted to films by casting method. Amoxicillin, as a model drug was incorporated to the copolymerized films to study the in-vitro drug release. The films obtained were evaluated by varying the pH to study the pH responsive nature of films. Drug release studies were performed to obtain the release profile of drug; water uptake capacity of the copolymerized film were measured to determine the swelling behaviour of the films. The films were further characterized using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Differential Scanning Calorimetry (DSC) to identify the structural and morphological changes along with thermal transitions. The results indicate that the synthesized copolymers are pH responsive in nature having great potential for application in controlled and targeted drug delivery.

scholarly journals Biodegradable pH-responsive hydrogels for controlled dual-drug release

2018 ◽  
Vol 6 (3) ◽  
pp. 510-517 ◽  
Author(s):  
Liang Xu ◽  
Linzi Qiu ◽  
Yang Sheng ◽  
Yixin Sun ◽  
Linhong Deng ◽  
...  
Keyword(s):  
Drug Release ◽  
Ph Responsive ◽  
Biodegradable Hydrogels ◽  
Responsive Hydrogels ◽  
Dual Drug

pH-Responsive biodegradable hydrogels based on NIPAM/AA and a PLLA/PEG macro-crosslinker demonstrated pH mediated differential release of doxorubicin and tetracycline.

scholarly journals pH-Sensitive N-doped carbon dots–heparin and doxorubicin drug delivery system: preparation and anticancer research

RSC Advances ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 9347-9356 ◽  
Author(s):  
Ming Zhang ◽  
Ping Yuan ◽  
Ninglin Zhou ◽  
Yutian Su ◽  
Maoni Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Triggered Drug Release ◽  
Model Drug ◽  
Doped Carbon Dots

In this study, doxorubicin (DOX) hydrochloride as a model drug, N-doped carbon dots as a drug carrier, and heparin as an auxiliary medicine were selected to design and prepare a multi-functional drug delivery system with pH-triggered drug release.

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