pH-Responsive Nanoscale Covalent Organic Polymers as a Biodegradable Drug Carrier for Combined Photodynamic Chemotherapy of Cancer

2018 ◽  
Vol 10 (17) ◽  
pp. 14475-14482 ◽  
Author(s):  
Hairong Wang ◽  
Wenwen Zhu ◽  
Jingjing Liu ◽  
Ziliang Dong ◽  
Zhuang Liu
Keyword(s):  
Drug Carrier ◽  
Organic Polymers ◽  
Ph Responsive

scholarly journals Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 1797-1805 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

Facile synthesis of Ca2+-crosslinked sodium alginate/graphene oxide hybrids as electro- and pH-responsive drug carrier

2020 ◽  
Vol 108 ◽  
pp. 110380 ◽  
Author(s):  
Yajing Yun ◽  
Hongwei Wu ◽  
Jun Gao ◽  
Wei Dai ◽  
Linhong Deng ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Sodium Alginate ◽  
Drug Carrier ◽  
Ph Responsive ◽  
Facile Synthesis

Cytotoxicity of pH-Responsive Dextrin Nanogels against Human Osteosarcoma 143B Cells

2014 ◽  
Vol 1060 ◽  
pp. 227-230
Author(s):  
Somkamon Manchun ◽  
Crispin R. Dass ◽  
Pornsak Sriamornsak
Keyword(s):  
Inhibition Efficiency ◽  
Treatment Time ◽  
Morphological Changes ◽  
Drug Carrier ◽  
Cross Linking ◽  
Dependent Manner ◽  
Ph Responsive ◽  
Human Osteosarcoma ◽  
Cell Inhibition ◽  
Smart Drug

To overcome major side-effects, that is, cardiotoxicity of doxorubicin (DOX), pH-responsive dextrin nanogels (DNGs) were developed for using as a smart drug carrier. DOX-loaded DNGs were fabricated by emulsion cross-linking technique using glyoxal as a cross-linking agent to form acid-sensitive, acetal bonds. The objective of this study was to investigate the cytotoxicity of DOX-loaded DNGs on the human osteosarcoma 143B cell line. The cytotoxicity assay results showed that DOX-loaded DNGs retained high cell inhibition efficiency in 143B cells in a concentration- and treatment time-dependent manner. The cytotoxicity decreased with increasing ratio of glyoxal to dextrin. Observation of 143B cells by light microscopy showed the morphological changes after treatment with DOX-loaded DNGs. These results suggested that DOX-loaded DNGs with pH-sensitive properties is promising for use as a drug delivery system for cancer therapy.

scholarly journals pH-responsive magnetic micelles gelatin-g-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe3O4 as a hydrophilic drug carrier

RSC Advances ◽  
2017 ◽  
Vol 7 (45) ◽  
pp. 28207-28212 ◽  
Author(s):  
Chao-Ming Su ◽  
Chen-Yu Huang ◽  
Yao-Li Chen ◽  
Tzong-Rong Ger
Keyword(s):  
Controlled Release ◽  
Drug Carrier ◽  
Magnetic Targeting ◽  
Ph Responsive ◽  
Hydrophilic Drug

In the study, pH-selective magnetic targeting micelle, Gelatin-g-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe3O4 (GPDF), has been synthesized for controlled release of a hydrophilic insulin-promoting factor, nicotinamide.

A pH-responsive asymmetric lipid vesicle as drug carrier

2016 ◽  
Vol 33 (7) ◽  
pp. 663-668 ◽  
Author(s):  
Xunan Zhang ◽  
Wei Zong ◽  
Ying Hu ◽  
Nan Luo ◽  
Wenlong Cheng ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Lipid Vesicle ◽  
Ph Responsive
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