scholarly journals Contribution of Human Herpesvirus 8 and Herpes Simplex Type 2 to Progression of Carotid Intima-Media Thickness in People Living With HIV

2019 ◽  
Vol 6 (2) ◽  
Author(s):  
Fernando Lidón ◽  
Sergio Padilla ◽  
Jose A García ◽  
Marta Fernández ◽  
Javier García ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Human Herpesvirus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Human Herpesvirus 8 ◽  
People Living With Hiv ◽  
Herpesvirus 8 ◽  
Factors Associated ◽  
Framingham Risk ◽  
Living With Hiv

Abstract Background Human herpesvirus 8 (HHV-8) is a lymphotropic and vasculotropic herpesvirus with potential pro-atherogenic effects. We explored the influence of coinfection with HHV-8 and other herpesviruses on the rate of progression of carotid intima-media thickness (cIMT) in virologically suppressed people living with HIV (PLWH). Methods Prospective cohort study including men who have sex with men (MSM) infected with HIV. At the baseline visit, IgG antibodies against HHV-8 and other herpesviruses, highly sensitive C-reactive protein (hsCRP) levels, and Framingham risk scores were measured. To evaluate the progression of cIMT, successive measurements with high-resolution carotid artery ultrasound were performed over an 8-year period. Adjusted general linear mixed models were used to assess factors associated with faster cIMT progression. Results One hundred forty-one participants with suppressed HIV-RNA (<200 copies/mL) at cIMT measurement during the study period were included. Forty-six (31.3%) were coinfected with HHV-8 and 76 (54%) with herpes simplex virus 2 (HSV-2). Factors associated with faster cIMT progression adjusting for CD4 cell counts, time between cIMT measurements, hepatitis C, varicella zoster virus, and cytomegalovirus coinfection were seropositivity for HHV-8 (P = .059), HSV-2+HHV-8 coinfection (P = .027), Framingham risk score (P = .057), and hsCRP (P = .027). Coinfection with HHV-8 was independently associated with higher levels of hsCRP (odds ratio, 1.09; 95% confidence interval, 1.02 to 1.17; P = .016). When hsCRP and HHV-8 were simultaneously included in the adjusted model, the relationship of HHV-8 with cIMT progression was attenuated. Conclusions HHV-8 might contribute to progression of cIMT with a more prominent role when it coinfects with HHV-2 in virologically suppressed PLWH, and this effect could be driven by systemic inflammation.

scholarly journals Seroprevalence and molecular diversity of Human Herpesvirus 8 among people living with HIV in Brazzaville, Congo

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Gervillien Arnold Malonga ◽  
Aude Jary ◽  
Valentin Leducq ◽  
Dimitry Moudiongui Mboungou Malanda ◽  
Anicet Luc Magloire Boumba ◽  
...  
Keyword(s):  
Whole Blood ◽  
Highly Active Antiretroviral Therapy ◽  
Horizontal Transmission ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Nuclear Antigen ◽  
People Living With Hiv ◽  
Subtype C ◽  
Herpesvirus 8 ◽  
Living With Hiv

AbstractHuman herpesvirus 8 (HHV8) is endemic in Africa, although studies of this infection are rare in Congo. We evaluated seroprevalence and HHV-8 diversity among people living with HIV. We included 353 patients receiving highly active antiretroviral therapy. Antibodies against HHV-8 latency-associated nuclear antigen were detected by indirect immunofluorescence. In HHV-8 positive patients, we performed HHV-8 quantification in blood and saliva by real-time PCR and typing by Sanger sequencing of K1 open reading frame. HHV-8 seroprevalence was 19%, being male (odd ratio [OR] = 1.741, [95% Confidence interval {CI}, 0.97–3.07]; p = 0.0581) and having multiple sex partners before HIV diagnosis (OR = 1.682, [CI 95%, 0.97–2.92]; p = 0.0629) tended to be associated with HHV-8 seropositivity. Of the 64 HHV-8 seropositive patients, HHV-8 DNA was detected in 10 (16%) in saliva, 6 (9%) in whole-blood and in 2 (3%) in both whole-blood and saliva. Three out of 6 HHV-8 strains were subtypes A5, 2 subtype B1 and 1 subtype C. HHV-8 seroprevalence was relatively low with more frequent carriage in men, associated with asymptomatic oral excretion and a predominance of subtype A5. These data tend to support the hypothesis of horizontal transmission in people living with HIV in Brazzaville.

Prevalence of human herpesvirus 8 infection in people living with HIV/AIDS in Pernambuco, Brazil

2016 ◽  
Vol 88 (11) ◽  
pp. 2016-2020 ◽  
Author(s):  
Georgea Gertrudes de Oliveira Mendes Cahú ◽  
Viviane Martha Santos Morais ◽  
Thaisa Regina Rocha Lopes ◽  
Dayvson Maurício da Silva ◽  
Tania Regina Tozetto-Mendoza ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
People Living With Hiv ◽  
Herpesvirus 8 ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals Limited Utility of Cardiovascular Risk Scores for People Living with HIV in Malawi

2020 ◽  
Author(s):  
Chia Goh ◽  
Henry Mwandumba ◽  
Alicja Rapala ◽  
Willard Tingao ◽  
Irene Sheha ◽  
...  
Keyword(s):  
Risk Score ◽  
Low Income ◽  
Intima Media Thickness ◽  
Risk Groups ◽  
Carotid Intima Media Thickness ◽  
Endothelial Damage ◽  
Risk Scores ◽  
People Living With Hiv ◽  
Cvd Risk ◽  
Living With Hiv

HIV is associated with increased cardiovascular disease (CVD) risk. Despite the high prevalence of HIV in low income subSaharan Africa, there are few data on the assessment of CVD risk in the region. In this study, we aimed to compare the utility of existing CVD risk scores in a cohort of Malawian adults, and assess to what extent they correlate with established markers of endothelial damage: carotid intima media thickness (IMT) and pulse wave velocity (PWV). WHO/ISH, SCORE, FRS, ASCVD, QRISK2 and D:A:D scores were calculated for 279 Malawian adults presenting with HIV and low CD4. Correlation of the calculated 10year CVD risk score with IMT and PWV was assessed using Spearmans rho. The median (IQR) age of patients was 37 (31 to 43) years and 122 (44%) were female. Median (IQR) blood pressure was 120/73mmHg (108/68 to 128/80) and 88 (32%) study participants had a new diagnosis of hypertension. The FRS and QRISK2 scores included the largest number of participants in this cohort (96% and 100% respectively). D:A:D, a risk score specific for people living with HIV, identified more patients in moderate and high risk groups. Although all scores correlated well with physiological markers of endothelial damage, FRS and QRISK2 correlated most closely with both IMT [r2 0.51, p<0.0001 and r2 0.47, p<0.0001 respectively] and PWV [r2 0.47, p<0.0001 and r2 0.5, p<0.0001 respectively]. Larger cohort studies are required to adapt and validate risk prediction scores in this region, so that limited healthcare resources can be effectively targeted.

scholarly journals The unholy trinity of human herpesvirus 8-associated malignancy in a person living with HIV-1

AIDS ◽  
2018 ◽  
Vol 32 (3) ◽  
pp. 404-406
Author(s):  
Christopher J.A. Duncan ◽  
Fraser G. Charlton ◽  
Mark Bower ◽  
David A. Price
Keyword(s):  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Associated Malignancy ◽  
Living With Hiv ◽  
Hiv 1

scholarly journals Prevalence of Human Herpesvirus-8 Salivary Shedding in HIV Increases with CD4 Count

2004 ◽  
Vol 83 (8) ◽  
pp. 639-643 ◽  
Author(s):  
M. Gandhi ◽  
D.M. Koelle ◽  
N. Ameli ◽  
P. Bacchetti ◽  
J.S. Greenspan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Herpesvirus ◽  
Etiologic Agent ◽  
Cd4 Count ◽  
Human Herpesvirus 8 ◽  
Pcr Analysis ◽  
Herpesvirus 8 ◽  
Cd4 Counts ◽  
Factors Associated ◽  
Immunodeficiency Virus

Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi’s sarcoma (KS), which occurs in epidemic form in human immunodeficiency virus(HIV)-infected individuals. Saliva is the only mucosal fluid in which infectious HHV-8 has been identified, although factors associated with HHV-8 salivary shedding remain unclear. Our study performed PCR analysis for HHV-8 DNA in saliva (and other body fluids) in 66 HIV- and HHV-8-co-infected women without KS so that we could examine predictors for HHV-8 DNA detection. CD4 count was the most significant predictor of HHV-8 salivary shedding, with increased prevalence of HHV-8 salivary DNA at higher CD4 counts. The odds of salivary HHV8 shedding at CD4 counts > = 350 cells/μL was 63 times the odds of shedding at CD4 < 350 (95%CI, 1.3–3078), with an increase in effect size when the analysis was restricted to those with a CD4 nadir > 200. Analysis of these data suggests an increased potential for HHV-8 transmission early in HIV infection, with implications for HHV-8 prevention.

scholarly journals Identification of Herpes Simplex Virus DNA and Lack of Human Herpesvirus-8 DNA in Mycosis Fungoides

2002 ◽  
Vol 82 (3) ◽  
pp. 214-216 ◽  
Author(s):  
Emel Erkek ◽  
Nilgün Sentürk ◽  
Irem Dinçer ◽  
Ali Ilgın Olut ◽  
Tanıl Kocagöz ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Mycosis Fungoides ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Simplex Virus
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