Prevalence of human herpesvirus 8 infection in people living with HIV/AIDS in Pernambuco, Brazil

2016 ◽  
Vol 88 (11) ◽  
pp. 2016-2020 ◽  
Author(s):  
Georgea Gertrudes de Oliveira Mendes Cahú ◽  
Viviane Martha Santos Morais ◽  
Thaisa Regina Rocha Lopes ◽  
Dayvson Maurício da Silva ◽  
Tania Regina Tozetto-Mendoza ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
People Living With Hiv ◽  
Herpesvirus 8 ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals Seroprevalence and molecular diversity of Human Herpesvirus 8 among people living with HIV in Brazzaville, Congo

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Gervillien Arnold Malonga ◽  
Aude Jary ◽  
Valentin Leducq ◽  
Dimitry Moudiongui Mboungou Malanda ◽  
Anicet Luc Magloire Boumba ◽  
...  
Keyword(s):  
Whole Blood ◽  
Highly Active Antiretroviral Therapy ◽  
Horizontal Transmission ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Nuclear Antigen ◽  
People Living With Hiv ◽  
Subtype C ◽  
Herpesvirus 8 ◽  
Living With Hiv

AbstractHuman herpesvirus 8 (HHV8) is endemic in Africa, although studies of this infection are rare in Congo. We evaluated seroprevalence and HHV-8 diversity among people living with HIV. We included 353 patients receiving highly active antiretroviral therapy. Antibodies against HHV-8 latency-associated nuclear antigen were detected by indirect immunofluorescence. In HHV-8 positive patients, we performed HHV-8 quantification in blood and saliva by real-time PCR and typing by Sanger sequencing of K1 open reading frame. HHV-8 seroprevalence was 19%, being male (odd ratio [OR] = 1.741, [95% Confidence interval {CI}, 0.97–3.07]; p = 0.0581) and having multiple sex partners before HIV diagnosis (OR = 1.682, [CI 95%, 0.97–2.92]; p = 0.0629) tended to be associated with HHV-8 seropositivity. Of the 64 HHV-8 seropositive patients, HHV-8 DNA was detected in 10 (16%) in saliva, 6 (9%) in whole-blood and in 2 (3%) in both whole-blood and saliva. Three out of 6 HHV-8 strains were subtypes A5, 2 subtype B1 and 1 subtype C. HHV-8 seroprevalence was relatively low with more frequent carriage in men, associated with asymptomatic oral excretion and a predominance of subtype A5. These data tend to support the hypothesis of horizontal transmission in people living with HIV in Brazzaville.

scholarly journals Contribution of Human Herpesvirus 8 and Herpes Simplex Type 2 to Progression of Carotid Intima-Media Thickness in People Living With HIV

2019 ◽  
Vol 6 (2) ◽  
Author(s):  
Fernando Lidón ◽  
Sergio Padilla ◽  
Jose A García ◽  
Marta Fernández ◽  
Javier García ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Human Herpesvirus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Human Herpesvirus 8 ◽  
People Living With Hiv ◽  
Herpesvirus 8 ◽  
Factors Associated ◽  
Framingham Risk ◽  
Living With Hiv

Abstract Background Human herpesvirus 8 (HHV-8) is a lymphotropic and vasculotropic herpesvirus with potential pro-atherogenic effects. We explored the influence of coinfection with HHV-8 and other herpesviruses on the rate of progression of carotid intima-media thickness (cIMT) in virologically suppressed people living with HIV (PLWH). Methods Prospective cohort study including men who have sex with men (MSM) infected with HIV. At the baseline visit, IgG antibodies against HHV-8 and other herpesviruses, highly sensitive C-reactive protein (hsCRP) levels, and Framingham risk scores were measured. To evaluate the progression of cIMT, successive measurements with high-resolution carotid artery ultrasound were performed over an 8-year period. Adjusted general linear mixed models were used to assess factors associated with faster cIMT progression. Results One hundred forty-one participants with suppressed HIV-RNA (<200 copies/mL) at cIMT measurement during the study period were included. Forty-six (31.3%) were coinfected with HHV-8 and 76 (54%) with herpes simplex virus 2 (HSV-2). Factors associated with faster cIMT progression adjusting for CD4 cell counts, time between cIMT measurements, hepatitis C, varicella zoster virus, and cytomegalovirus coinfection were seropositivity for HHV-8 (P = .059), HSV-2+HHV-8 coinfection (P = .027), Framingham risk score (P = .057), and hsCRP (P = .027). Coinfection with HHV-8 was independently associated with higher levels of hsCRP (odds ratio, 1.09; 95% confidence interval, 1.02 to 1.17; P = .016). When hsCRP and HHV-8 were simultaneously included in the adjusted model, the relationship of HHV-8 with cIMT progression was attenuated. Conclusions HHV-8 might contribute to progression of cIMT with a more prominent role when it coinfects with HHV-2 in virologically suppressed PLWH, and this effect could be driven by systemic inflammation.

scholarly journals The unholy trinity of human herpesvirus 8-associated malignancy in a person living with HIV-1

AIDS ◽  
2018 ◽  
Vol 32 (3) ◽  
pp. 404-406
Author(s):  
Christopher J.A. Duncan ◽  
Fraser G. Charlton ◽  
Mark Bower ◽  
David A. Price
Keyword(s):  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Associated Malignancy ◽  
Living With Hiv ◽  
Hiv 1

Human Herpesvirus 8 (HHV-8) Infection in HIV/AIDS Patients From Santos, Brazil: Seroprevalence and Associated Factors

2005 ◽  
Vol 32 (1) ◽  
pp. 57-63 ◽  
Author(s):  
L??gia Camera Pierrotti ◽  
Arnaldo Etzel ◽  
Laura Masami Sumita ◽  
Patr??cia Emilia Braga ◽  
Jos?? Eluf-Neto ◽  
...  
Keyword(s):  
Associated Factors ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Aids Patients ◽  
Herpesvirus 8 ◽  
Hiv Aids
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