Vitamin K Activity of Menadione Sodium Bisulfite in Chickens

1956 ◽  
Vol 59 (2) ◽  
pp. 181-196 ◽  
Author(s):  
Douglas V. Frost ◽  
Henry S. Perdue ◽  
Henry C. Spruth
Keyword(s):  
Vitamin K ◽  
Sodium Bisulfite ◽  
Menadione Sodium Bisulfite ◽  
K Activity

scholarly journals Comparison of Vitamin K Activities of Vitamin K1 and Klotogen (Menadione Sodium Bisulfite Complex)

1957 ◽  
Vol 36 (3) ◽  
pp. 633-635 ◽  
Author(s):  
Henry S. Perdue ◽  
Henry C. Spruth ◽  
Douglas V. Frost
Keyword(s):  
Vitamin K ◽  
Sodium Bisulfite ◽  
Vitamin K1 ◽  
Menadione Sodium Bisulfite

Injections of a Vitamin-K Compound in Mothers and Hyperbilirubinemia in the Newborn

PEDIATRICS ◽  
1958 ◽  
Vol 22 (3) ◽  
pp. 605-606
Author(s):  
JEROLD F. LUCEY ◽  
ROBERT G. DOLAN
Keyword(s):  
Premature Infants ◽  
Vitamin K ◽  
Exchange Transfusion ◽  
Sodium Bisulfite ◽  
Menadione Sodium Bisulfite

Recently we became aware of an association between the administration of a large amount, 72 mg, of a vitamin-K analogue (menadione sodium bisulfite, Hykinone®) intravenously to mothers in labor and the occurrence of marked, early hyperbilirubinemia in newborn premature infants. We have encountered seven such cases, the details of which are listed in the Table. These infants were first noted to have markedly elevated levels of bilirubin in the serum between 40 and 72 hours of age. All but one were treated with exchange transfusion in an effort to prevent neurologic damage (kernicterus) from hyperbilirubinemia.

scholarly journals VITAMIN K ACTIVITY IN THE BENZOQUINONE SERIES

1939 ◽  
Vol 131 (1) ◽  
pp. 399-400
Author(s):  
S. Ansbaciier ◽  
Erhard Fernkolz
Keyword(s):  
Vitamin K ◽  
K Activity

scholarly journals Bioavailability and Chemical/Functional Aspects of Synthetic MK-7 vs Fermentation-Derived MK-7 in Randomised Controlled Trials

2017 ◽  
Vol 87 (5-6) ◽  
pp. 1-15 ◽  
Author(s):  
Mona Møller ◽  
Ingrid M. Fange Gjelstad ◽  
Ingebjørg Baksaas ◽  
Tone Grande ◽  
Inger Reidun Aukrust ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Vitamin K ◽  
Healthy Subjects ◽  
Biological Effects ◽  
Daily Intake ◽  
Functional Study ◽  
Randomised Controlled ◽  
Double Blinded ◽  
Synthetic Form ◽  
K Activity

Abstract. We investigated the bioavailability of a synthetic form of the vitamin K2 molecule menaquinone-7 (MK-7) in a randomised single-blinded two-way cross-over study. Healthy subjects (20 – 66 years of age) took a single 180 μg dose of synthetic MK-7 or fermentation-derived MK-7, and serum MK-7 concentrations were monitored for 72 hours to calculate AUC(0 – 72 h) and Cmax. We also compared the biological effects of placebo, fermentation-derived MK-7 (90 μg) and 3 doses of synthetic MK-7(45, 90 and 180 μg) in a randomised double-blinded parallel study. Healthy subjects (20 – 60 years of age) took one of the supplements daily for 43 days, and the fraction of carboxylated osteocalcin (OC) was compared between day 1 and day 43 as a marker for vitamin K activity. In the bioavailability study, the 90 % confidence interval for the ratio of the AUC(0-72 h) values for synthetic and fermentationderived MK-7 was 83 – 111, indicating bioequivalence. The 90 % confidence interval for the Cmax ratio was 83 – 131. The serum concentrations of carboxylated OC and undercarboxylated OC were increased (p = 0.01) and reduced (p = 0.02), respectively, after daily intake of 180 μg of synthetic MK-7 for 43 days, indicating increased vitamin K activity. Across both studies, only 1 participant reported an adverse event (dry mouth; 180 μg synthetic MK-7 group, functional study) that was considered possibly related to synthetic MK-7 supplementation. Our findings provide evidence that the tested synthetic form of MK-7 is bioequivalent to fermentation-derived MK-7, exhibits vitamin K activity and is well tolerated in healthy subjects.

Sign in / Sign up

Export Citation Format

Share Document