scholarly journals Activity of Vitamin K1 and Menadione Sodium Bisulfite Complex When Measured by Mortality of Chicks with Cecal Coccidiosis

1962 ◽  
Vol 41 (6) ◽  
pp. 1836-1839 ◽  
Author(s):  
R.H. Harms ◽  
P.W. Waldroup ◽  
D.D. Cox
Keyword(s):  
Sodium Bisulfite ◽  
Vitamin K1 ◽  
Menadione Sodium Bisulfite

scholarly journals Comparison of Vitamin K Activities of Vitamin K1 and Klotogen (Menadione Sodium Bisulfite Complex)

1957 ◽  
Vol 36 (3) ◽  
pp. 633-635 ◽  
Author(s):  
Henry S. Perdue ◽  
Henry C. Spruth ◽  
Douglas V. Frost
Keyword(s):  
Vitamin K ◽  
Sodium Bisulfite ◽  
Vitamin K1 ◽  
Menadione Sodium Bisulfite

Menadione sodium bisulfite inhibits the toxic aggregation of amyloid-β(1–42)

2018 ◽  
Vol 1862 (10) ◽  
pp. 2226-2235 ◽  
Author(s):  
Yu Zhang ◽  
Yudan Zhao ◽  
Zhuoyi Wang ◽  
Hao Gong ◽  
Liang Ma ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Sodium Bisulfite ◽  
Menadione Sodium Bisulfite

scholarly journals Combined Effect of Bortezomib and Menadione Sodium Bisulfite on Proteasomes of Tumor Cells: The Dramatic Decrease of Bortezomib Toxicity in a Preclinical Trial

Cancers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 351 ◽  
Author(s):  
Tatiana Astakhova ◽  
Alexey Morozov ◽  
Pavel Erokhov ◽  
Maria Mikhailovskaya ◽  
Sergey Akopov ◽  
...  
Keyword(s):  
High Efficiency ◽  
Sodium Bisulfite ◽  
Proteasome Activity ◽  
26S Proteasome ◽  
Mammary Adenocarcinoma ◽  
Antitumor Drugs ◽  
Antitumor Effects ◽  
Preclinical Trial ◽  
Menadione Sodium Bisulfite

Tumor growth is associated with elevated proteasome expression and activity. This makes proteasomes a promising target for antitumor drugs. Current antitumor drugs such as bortezomib that inhibit proteasome activity have significant side effects. The purpose of the present study was to develop effective low-toxic antitumor compositions with combined effects on proteasomes. For compositions, we used bortezomib in amounts four and ten times lower than its clinical dose, and chose menadione sodium bisulfite (MSB) as the second component. MSB is known to promote oxidation of NADH, generate superoxide radicals, and as a result damage proteasome function in cells that ensure the relevance of MSB use for the composition development. The proteasome pool was investigated by the original native gel electrophoresis method, proteasome chymotrypsin-like activity—by Suc-LLVY-AMC-hydrolysis. For the compositions, we detected 10 and 20 μM MSB doses showing stronger proteasome-suppressing and cytotoxic in cellulo effects on malignant cells than on normal ones. MSB indirectly suppressed 26S-proteasome activity in cellulo, but not in vitro. At the same time, MSB together with bortezomib displayed synergetic action on the activity of all proteasome forms in vitro as well as synergetic antitumor effects in cellulo. These findings determine the properties of the developed compositions in vivo: antitumor efficiency, higher (against hepatocellular carcinoma and mammary adenocarcinoma) or comparable to bortezomib (against Lewis lung carcinoma), and drastically reduced toxicity (LD50) relative to bortezomib. Thus, the developed compositions represent a novel generation of bortezomib-based anticancer drugs combining high efficiency, low general toxicity, and a potentially expanded range of target tumors.

Comparison of Gas Chromatographic Calibration Methods for Analysis of Menadione and Menadione Sodium Bisulfite Content of Pharmaceutical Products

1972 ◽  
Vol 55 (3) ◽  
pp. 660-661
Author(s):  
A J Shepparid ◽  
W D Hubbard ◽  
A R Prosser
Keyword(s):  
Comparative Study ◽  
Internal Standard ◽  
Pharmaceutical Products ◽  
Sodium Bisulfite ◽  
Butylated Hydroxyanisole ◽  
Menadione Sodium Bisulfite ◽  
Calibration Methods ◽  
Significant Difference ◽  
External Standard

Abstract A comparative study was made of 2 GLC calibration methods for determining the menadione and menadione sodium bisulfite content of pharmaceuticals. One method utilizes an external standard and the second method makes use of butylated hydroxyanisole as an internal standard. Measurements were made on 8 pure solutions of known concentration of menadione and on 5 pharmaceuticals containing menadione or menadione sodium bisulfite. No significant difference was found between the results obtained by the 2 methods.

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