Relative Toxicity and Intensity of Synergism of Mixtures of Piperonyl Butoxide with the cis Isomers of Allethrin as House Fly Sprays

1958 ◽  
Vol 51 (5) ◽  
pp. 675-678 ◽  
Author(s):  
W. A. Gersdorff ◽  
P. G. Piquett
Keyword(s):  
House Fly ◽  
Piperonyl Butoxide ◽  
Relative Toxicity

Abbau und Toxizität von Hexachlorbicyclo [2.2.1]-hept-5-en- Derivaten (Cyclodien-Insektizide) / Structural Aspects of Biological Conversion and Toxicity of Hexachloro-norbornene Derivatives (Cyclodiene-Insecticides)

1973 ◽  
Vol 28 (3-4) ◽  
pp. 107-112 ◽  
Author(s):  
W. Rückert ◽  
K. Ballschmiter
Keyword(s):  
Molecular Structure ◽  
Musca Domestica ◽  
Oxidative Metabolism ◽  
House Fly ◽  
Piperonyl Butoxide ◽  
Biological Conversion ◽  
Cyclodiene Insecticides ◽  
Derivatives Of ◽  
Norbornene Derivatives ◽  
Structural Aspects

The aspects of molecular-structure and biological conversion have been studied for 12 derivatives of the endosulfan ether 1 [4, 5, 6, 7, 8, 8- hexachloro- 1, 3, 3a, 4, 7, 7a- hexahydro- 4, 7-methanoisobenzofuran]. Adults of a normal house-fly strain (Musca domestica) have been used in the assay. Derivatives of 1 monosubstituted in position I are found to be converted substantially faster than products disubstituted in position I and 3, respectively. Metabolism is inhibited for all compounds studied after application of piperonyl butoxide as a synergist. Besides proving that on oxidative metabolism has to be discussed and in fact could be proved for some derivatives, the intrinsic toxicity of the compounds studied shows up under these conditions. Some derivatives known to be metabolites of the pesticide Endosulfan® show a high intrinsic toxicity to houseflies if the oxidative metabolism is inhibited.

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