Impact of the mutational load on the virological response to a first-line rilpivirine-based regimen

2018 ◽  
Vol 74 (3) ◽  
pp. 718-721
Author(s):  
Chloé Dimeglio ◽  
Stéphanie Raymond ◽  
Florence Nicot ◽  
Nicolas Jeanne ◽  
Romain Carcenac ◽  
...  
Keyword(s):  
Virological Response ◽  
Mutational Load ◽  
First Line

Virological Response and Resistance Profiles After 24 Months of First-Line Antiretroviral Treatment in Adults Living in Bangui, Central African Republic

2012 ◽  
Vol 28 (4) ◽  
pp. 315-323 ◽  
Author(s):  
Hélène Péré ◽  
Charlotte Charpentier ◽  
Pascal Mbelesso ◽  
Marius Dandy ◽  
Mathieu Matta ◽  
...  
Keyword(s):  
Virological Response ◽  
Central African Republic ◽  
Antiretroviral Treatment ◽  
First Line

scholarly journals No impact of HIV-1 protease minority resistant variants on the virological response to a first-line PI-based regimen containing darunavir or atazanavir

2017 ◽  
Vol 73 (1) ◽  
pp. 173-176 ◽  
Author(s):  
Marine Perrier ◽  
Benoit Visseaux ◽  
Roland Landman ◽  
Véronique Joly ◽  
Eve Todesco ◽  
...  
Keyword(s):  
Virological Response ◽  
First Line ◽  
Hiv 1

scholarly journals First-line antiretroviral treatment and virological response among HIV adult patients at an accredited HIV care center, Cameroon

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Juste Patient Mbébi Enoné ◽  
Calixte Ida Penda ◽  
Serge Bruno Ebong ◽  
Madeleine Mbangue ◽  
Samuel Honoré Mandengué ◽  
...  
Keyword(s):  
Virological Response ◽  
Antiretroviral Treatment ◽  
Care Center ◽  
Adult Patients ◽  
Hiv Care ◽  
First Line

scholarly journals HIV multi-drug resistance at first-line antiretroviral failure and subsequent virological response in Asia

2014 ◽  
Vol 17 (1) ◽  
pp. 19053 ◽  
Author(s):  
Awachana Jiamsakul ◽  
Somnuek Sungkanuparph ◽  
Matthew Law ◽  
Rami Kantor ◽  
Jutarat Praparattanapan ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Virological Response ◽  
Multi Drug Resistance ◽  
First Line

scholarly journals Impact of pre-therapy viral load on virological response to modern first-line HAART

2013 ◽  
Vol 18 (7) ◽  
pp. 867-876 ◽  
Author(s):  
Maria Mercedes Santoro ◽  
Daniele Armenia ◽  
Claudia Alteri ◽  
Philippe Flandre ◽  
Andrea Calcagno ◽  
...  
Keyword(s):  
Viral Load ◽  
Virological Response ◽  
First Line

scholarly journals Clinical and virological response to antiretroviral drugs among HIV patients on first-line treatment in Dar-es-Salaam, Tanzania

2014 ◽  
Vol 8 (07) ◽  
pp. 845-852 ◽  
Author(s):  
Fausta Mosha ◽  
Johanna Ledwaba ◽  
Faustine Ndugulile ◽  
Zipora Ng’ang’a ◽  
Peter Nsubuga ◽  
...  
Keyword(s):  
Viral Load ◽  
Clinical Response ◽  
Virological Response ◽  
Dar Es Salaam ◽  
Antiretroviral Drugs ◽  
Resistance Mutations ◽  
First Line ◽  
Hiv Viral Load ◽  
Median Percentage ◽  
Nnrti Resistance

Introduction: In Tanzania, the follow-up on antiretroviral therapy (ART) response is based on clinical outcomes. We investigated virological response and ARV resistance mutations in relation to clinical response in ARV-treated patients. Methodology: A cross-sectional study of a cohort of 150 patients taking first-line ART in Dar-es-Salaam was conducted. Data were collected using standardized questionnaires and patients’ blood samples. HIV viral load testing and genotyping was performed on all viremic samples. Statistical analyses compared clinical responders and non-responders. Results: The median time on ART was 20 months; 71 (47%) patients were ART clinical responders. Clinical non-responders were more likely to have started ART with advanced disease with significantly lower median percentage weight gain (6% versus 20%) with respect to pre-treatment levels. Sixty-one (86%) and 64 (81%) of clinical responders and non-responders, respectively, had undetectable viral loads. Genotyping was successful in 24 (96%) virologically failing patients, among whom 83% had resistance mutations; 67% had dual nucleoside reverse transcriptase inhibitor (NRTI)/non-NRTI (NNRTI) resistance mutations. Seventeen (71%) and 19 (79%) patients had NRTI and NNRTI resistance mutations, respectively, which were related to the ART in use, with no difference between clinical responders and non-responders. The most prevalent subtypes were A and C, found in 9 (38%) and 7 (29%) patients, respectively. Conclusions: The observed virological response was high and did not correlate with clinical response. The prevalence of ARV resistance mutations was high in viraemic patients and was related to the ARV prescribed. We recommend use of viral load monitoring during ART in Tanzania.

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