Effect of low concentrations of clavulanic acid on the in-vitro activity of amoxycillin against β-lactamase-producing Branhamella catarrhalis and Haemophilus influenzae

1990 ◽  
Vol 26 (3) ◽  
pp. 371-380 ◽  
Author(s):  
Christine E. Cooper ◽  
Brian Slocombe ◽  
Anthony R. White
Keyword(s):  
Haemophilus Influenzae ◽  
Clavulanic Acid ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Low Concentrations ◽  
Branhamella Catarrhalis

scholarly journals In Vitro Activity of the Ketolide ABT-773

2001 ◽  
Vol 45 (10) ◽  
pp. 2922-2924 ◽  
Author(s):  
Arthur L. Barry ◽  
Peter C. Fuchs ◽  
Steven D. Brown
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
In Vitro Activity ◽  
Low Concentrations ◽  
Resistant Strains

ABSTRACT The in vitro activities of ABT-773, azithromycin, erythromycin, and clindamycin were compared by testing 1,223 clinical isolates selected to represent different species and phenotypes. ABT-773 was particularly potent against staphylococci (the MIC at which 90% of the strains tested were inhibited [MIC90] was ≤0.06 μg/ml), including all strains that were macrolide resistant but clindamycin susceptible.Streptococcus pneumoniae and other streptococci were inhibited by low concentrations of ABT-773, and that included most erythromycin-resistant strains. Against Haemophilus influenzae, ABT-773 and azithromycin were similar in their antibacterial potency (MIC90, 4.0 and 2.0 μg/ml, respectively).

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