scholarly journals Y chromosome gr/gr deletions are a risk factor for low semen quality

2009 ◽  
Vol 24 (10) ◽  
pp. 2667-2673 ◽  
Author(s):  
L. Visser ◽  
G.H. Westerveld ◽  
C.M. Korver ◽  
S.K.M. van Daalen ◽  
S.E. Hovingh ◽  
...  
Keyword(s):  
Risk Factor ◽  
Y Chromosome ◽  
Semen Quality

scholarly journals Occurrence of Gonadoblastoma in Females with Turner Syndrome and Y Chromosome Material: A Population Study*

2000 ◽  
Vol 85 (9) ◽  
pp. 3199-3202 ◽  
Author(s):  
Claus Højbjerg Gravholt ◽  
Jens Fedder ◽  
Rune Weis Naeraa ◽  
Jørn Müller
Keyword(s):  
Risk Factor ◽  
Turner Syndrome ◽  
Y Chromosome ◽  
Carcinoma In Situ ◽  
Dna Analysis ◽  
Epidemiological Studies ◽  
Histopathological Evaluation ◽  
Primer Sets ◽  
Chromosome Material

Abstract The presence of Y chromosome material in patients with Turner syndrome is a risk factor for the development of gonadoblastoma. However, no cases with gonadoblastoma or other ovarian malignancies have been found in epidemiological studies of cancer, morbidity, or mortality in Turner syndrome. We examined 114 females with Turner syndrome for the presence of Y chromosome material by PCR. Initially, five different primer sets were used. Y Chromosome-positive individuals were further examined with an additional four primer sets. We found 14 (12.2%; 95% confidence interval, 6.9–19.7%) patients who had Y chromosome material. The karyotype in 7 of these patients did not suggest the presence of Y chromosome material. Seven of the patients had been ovariectomized before entering the study due to verified Y chromosome material, whereas three patients were operated upon after the DNA analysis. The histopathological evaluations showed that 1 of the 10 ovariectomized patients actually had a gonadoblastoma. The rest of the patients did not have gonadoblastoma or carcinoma in situ on histopathological evaluation. Three patients (age, >50 yr) positive for Y chromosome material chose not to have ovariectomy performed, and detailed ultrasonographies did not suggest the presence of gonadoblastoma. The frequency of Y chromosome material is high in Turner syndrome (12.2%), but the occurrence of gonadoblastoma among Y-positive patients seems to be low (7–10%), and the risk may have been overestimated in previous studies, perhaps due to problems with selection bias. This study emphasizes the need for prospective unbiased studies.

Partial duplication atAZFcon the Y chromosome is a risk factor for impaired spermatogenesis in Han Chinese in Taiwan

2007 ◽  
Vol 28 (5) ◽  
pp. 486-494 ◽  
Author(s):  
Yi-Wen Lin ◽  
Lea Chia-Ling Hsu ◽  
Pao-Lin Kuo ◽  
William J. Huang ◽  
Han-Sun Chiang ◽  
...  
Keyword(s):  
Risk Factor ◽  
Y Chromosome ◽  
Han Chinese ◽  
Partial Duplication

scholarly journals Is low body mass index a risk factor for semen quality? A PRISMA-compliant meta-analysis

Medicine ◽  
2019 ◽  
Vol 98 (32) ◽  
pp. e16677 ◽  
Author(s):  
Dan Guo ◽  
Min Xu ◽  
Qifan Zhou ◽  
Chunhua Wu ◽  
Rong Ju ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Risk Factor ◽  
Body Mass ◽  
Semen Quality ◽  
Meta Analysis ◽  
Low Body Mass Index

Partial Microdeletions in the Y-Chromosome AZFc Region Are Not a Significant Risk Factor for Spermatogenic Impairment in Tunisian Infertile Men

2012 ◽  
Vol 16 (7) ◽  
pp. 775-779 ◽  
Author(s):  
Myriam Ghorbel ◽  
Siwar Baklouti Gargouri ◽  
Nacira Zribi ◽  
Fatma Ben Abdallah ◽  
Mariem Cherif ◽  
...  
Keyword(s):  
Risk Factor ◽  
Y Chromosome ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Azfc Region ◽  
Infertile Men

Semen quality in men with Y chromosome aberrations

2010 ◽  
Vol 34 (5pt1) ◽  
pp. 453-460 ◽  
Author(s):  
A. Antonelli ◽  
L. Marcucci ◽  
R. Elli ◽  
N. Tanzi ◽  
D. Paoli ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Chromosome Aberrations ◽  
Semen Quality

scholarly journals Is smoking a risk factor for decreased semen quality? A cross-sectional analysis

2006 ◽  
Vol 22 (1) ◽  
pp. 188-196 ◽  
Author(s):  
C.H. Ramlau-Hansen ◽  
A.M. Thulstrup ◽  
A.S. Aggerholm ◽  
M.S. Jensen ◽  
G. Toft ◽  
...  
Keyword(s):  
Risk Factor ◽  
Semen Quality ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

Age of Fathers of Azoospermic Men with Y-Chromosome Deletions: A Genetic Risk Factor?

2000 ◽  
Vol 74 (3) ◽  
pp. S123
Author(s):  
M.J Hyman ◽  
P.T Chan ◽  
M Goldstein ◽  
P.N Schlegel
Keyword(s):  
Risk Factor ◽  
Y Chromosome ◽  
Genetic Risk ◽  
Genetic Risk Factor ◽  
Chromosome Deletions

Is p53 controlling spermatogenesis in male mice with the deletion on the Y chromosome?

Zygote ◽  
2011 ◽  
Vol 21 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Tomasz Lech ◽  
Aniela Golas ◽  
Jozefa Styrna
Keyword(s):  
Y Chromosome ◽  
Semen Quality ◽  
Sperm Quality ◽  
Membrane Integrity ◽  
Quality Parameters ◽  
Quality Parameter ◽  
Sperm Head ◽  
Testis Weight ◽  
Male Mice ◽  
Chromosome Y

SummaryThe aim of the study was to evaluate the influence of the chromosome Y structure and Trp53 genotype on semen quality parameters. Mice with partial deletion of the Y chromosome (B10.BR-Ydel) have severely altered sperm head morphology when compared with males that possess the complete Y chromosome (B10.BR). Control males from B10.BR and B10.BR-Ydel mice, and mutant males from B10.BR-p53−/− and B10.BR-Ydel-p53−/− experimental groups were used. We assessed testis weight, sperm head abnormalities, viability of spermatozoa (eosin test), percentage of motile and immature sperm, and performed a hypo-osmotic test to detect abnormal tail membrane integrity. Sperm morphology and maturation were controlled by the genes within the deleted region of the Y chromosome. Testis weight was higher in the mutants than in the control males, possibly due to cell accumulation in Trp53-deficient males as the concentration of sperm was significantly increased in the mutants. An elevated percentage of abnormal sperm was noted in B10.BR-p53−/− and B10.BR-Ydel-p53−/− male mice. We suggest that, in Trp53-deficient mice, the sperm cells that escape apoptosis are the ones that have abnormal morphology. The only sperm quality parameter affected by the interplay between Trp53 and chromosome Y genes was sperm motility, which was elevated in B10.BR-p53−/− males, but remained unchanged in B10.BR-Ydel-p53−/− males.

Y chromosome TSPY copy numbers and semen quality

2010 ◽  
Vol 94 (5) ◽  
pp. 1744-1747 ◽  
Author(s):  
Bita Nickkholgh ◽  
Michiel J. Noordam ◽  
Suzanne E. Hovingh ◽  
Ans M.M. van Pelt ◽  
Fulco van der Veen ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Semen Quality ◽  
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