scholarly journals Transcriptional profiling of the developmentally important signalling pathways in human embryonic stem cells

2005 ◽  
Vol 21 (2) ◽  
pp. 405-412 ◽  
Author(s):  
Jeung-Yon Rho ◽  
Kweon Yu ◽  
Jee-Soo Han ◽  
Jung-Il Chae ◽  
Deog-Bon Koo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Transcriptional Profiling ◽  
Embryonic Stem ◽  
Signalling Pathways

Transcriptional profiling of initial differentiation events in human embryonic stem cells

2004 ◽  
Vol 323 (2) ◽  
pp. 453-464 ◽  
Author(s):  
John D. Calhoun ◽  
Raj R. Rao ◽  
Susanne Warrenfeltz ◽  
Romdhane Rekaya ◽  
Stephen Dalton ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Transcriptional Profiling ◽  
Embryonic Stem

Genome-Wide Transcriptional Profiling of Human Embryonic Stem Cells Differentiating to Cardiomyocytes

Stem Cells ◽  
2006 ◽  
Vol 24 (8) ◽  
pp. 1956-1967 ◽  
Author(s):  
Abdelaziz Beqqali ◽  
Jantine Kloots ◽  
Dorien Ward-van Oostwaard ◽  
Christine Mummery ◽  
Robert Passier
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Transcriptional Profiling ◽  
Embryonic Stem ◽  
Genome Wide

scholarly journals Early Cell Fate Decisions of Human Embryonic Stem Cells and Mouse Epiblast Stem Cells Are Controlled by the Same Signalling Pathways

PLoS ONE ◽  
2009 ◽  
Vol 4 (6) ◽  
pp. e6082 ◽  
Author(s):  
Ludovic Vallier ◽  
Thomas Touboul ◽  
Zhenzhi Chng ◽  
Minodora Brimpari ◽  
Nicholas Hannan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cell Fate ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Signalling Pathways ◽  
Cell Fate Decisions ◽  
Epiblast Stem Cells

scholarly journals Transcriptional Profiling of Ectoderm Specification to Keratinocyte Fate in Human Embryonic Stem Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0122493 ◽  
Author(s):  
Ana Mafalda Baptista Tadeu ◽  
Samantha Lin ◽  
Lin Hou ◽  
Lisa Chung ◽  
Mei Zhong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Transcriptional Profiling ◽  
Embryonic Stem

Isolation and Transcriptional Profiling of Purified Hepatic Cells Derived from Human Embryonic Stem Cells

Stem Cells ◽  
2008 ◽  
Vol 26 (8) ◽  
pp. 2032-2041 ◽  
Author(s):  
Eric Chiao ◽  
Menashe Elazar ◽  
Yi Xing ◽  
Anming Xiong ◽  
Muriel Kmet ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Transcriptional Profiling ◽  
Embryonic Stem ◽  
Hepatic Cells

APELIN promotes hematopoiesis from human embryonic stem cells

Blood ◽  
2012 ◽  
Vol 119 (26) ◽  
pp. 6243-6254 ◽  
Author(s):  
Qing C. Yu ◽  
Claire E. Hirst ◽  
Magdaline Costa ◽  
Elizabeth S. Ng ◽  
Jacqueline V. Schiesser ◽  
...  
Keyword(s):  
Stem Cells ◽  
Endothelial Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Transcriptional Profiling ◽  
Embryonic Stem ◽  
Embryoid Bodies ◽  
Peptide Ligand ◽  
The Media ◽  
Apelin Receptor

Abstract Transcriptional profiling of differentiating human embryonic stem cells (hESCs) revealed that MIXL1-positive mesodermal precursors were enriched for transcripts encoding the G-protein–coupled APELIN receptor (APLNR). APLNR-positive cells, identified by binding of the fluoresceinated peptide ligand, APELIN (APLN), or an anti-APLNR mAb, were found in both posterior mesoderm and anterior mesendoderm populations and were enriched in hemangioblast colony-forming cells (Bl-CFC). The addition of APLN peptide to the media enhanced the growth of embryoid bodies (EBs), increased the expression of hematoendothelial genes in differentiating hESCs, and increased the frequency of Bl-CFCs by up to 10-fold. Furthermore, APLN peptide also synergized with VEGF to promote the growth of hESC-derived endothelial cells. These studies identified APLN as a novel growth factor for hESC-derived hematopoietic and endothelial cells.

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