scholarly journals An in-vitro study of ginsenoside Rb1-induced teratogenicity using a whole rat embryo culture model

2003 ◽  
Vol 18 (10) ◽  
pp. 2166-2168 ◽  
Author(s):  
L.Y. Chan
Keyword(s):  
Embryo Culture ◽  
In Vitro Study ◽  
Vitro Study ◽  
Ginsenoside Rb1 ◽  
Rat Embryo ◽  
Culture Model ◽  
Rat Embryo Culture

Comparative embryotoxicity of different antimalarial peroxides: In vitro study using the rat whole embryo culture model (WEC)☆

2010 ◽  
Vol 30 (4) ◽  
pp. 583-590 ◽  
Author(s):  
Monica Longo ◽  
Sara Zanoncelli ◽  
Marco Brughera ◽  
Paolo Colombo ◽  
Sergio Wittlin ◽  
...  
Keyword(s):  
Embryo Culture ◽  
In Vitro Study ◽  
Vitro Study ◽  
Whole Embryo Culture ◽  
Culture Model

Bringing benign ectomesenchymal odontogenic tumours to the lab: an in vitro study using an organotypic culture model

2018 ◽  
Author(s):  
Victor Coutinho Bastos ◽  
Núbia Braga Pereira ◽  
Marina Gonçalves Diniz ◽  
Luciana Oliveira Andrade ◽  
Wagner Henriques Castro ◽  
...  
Keyword(s):  
Organotypic Culture ◽  
In Vitro Study ◽  
Vitro Study ◽  
Odontogenic Tumours ◽  
Culture Model

scholarly journals A study of diclofenac-induced teratogenicity during organogenesis using a whole rat embryo culture model

2001 ◽  
Vol 16 (11) ◽  
pp. 2390-2393 ◽  
Author(s):  
L.Y. Chan ◽  
P.Y. Chiu ◽  
S.S.N. Siu ◽  
T.K. Lau
Keyword(s):  
Embryo Culture ◽  
Rat Embryo ◽  
Culture Model ◽  
Rat Embryo Culture

Evaluation of the rat embryo culture system as a predictive test for human teratogens

1994 ◽  
Vol 72 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Ian Guest ◽  
Harpal S. Buttar ◽  
Susan Smith ◽  
Daya R. Varma
Keyword(s):  
Valproic Acid ◽  
Embryo Culture ◽  
Culture System ◽  
Enzyme Inhibitor ◽  
False Negative ◽  
Predictive Test ◽  
Rat Embryo ◽  
Vitro Assay ◽  
Rat Embryo Culture

Ingestion of the anticonvulsant drag valproic acid and of the angiotensin converting enzyme inhibitor captopril during pregnancy has been associated with abnormal fetal outcome in humans. In contrast, the use of the antiinflammatory drug ibuprofen and the antihistamine diphenhydramine has not been documented to be embryotoxic in humans. We evaluated the rat embryo culture system as a predictive model of teratogenesis, using these four drugs as test agents. Valproic acid, ibuprofen, and diphenhydramine were embryotoxic, inducing concentration-dependent decreases in growth and a significant increase in anomalies. Valproic acid caused an increase in neural tube defects, ibuprofen increased the incidence of abnormal maxillary processes, and diphenhydramine increased the number of embryos with distorted body morphology. These abnormalities were induced at concentrations of valproic acid and diphenhydramine that are used clinically, but ibuprofen only induced toxicity at concentrations greatly exceeding the therapeutic range. Captopril was not embryotoxic up to 5 mM, the highest concentration tested. These results suggest that the rat embryo culture system produces both false positive and false negative data on the teratogenic potential of drugs. Although such an in vitro assay may be suitable to determine the mechanism of teratogenesis, it is not a sensitive indicator of potential human teratogens on its own. These data support the view that in vitro systems can only supplement clinical and epidemiological observations in humans, possibly as a method to determine mechanisms of actions of teratogens.Key words: embryo culture, teratogenesis, valproic acid, captopril, ibuprofen, diphenhydramine.

Study of embryotoxicity of Fusarium mycotoxin butenolide using a whole rat embryo culture model

2011 ◽  
Vol 25 (8) ◽  
pp. 1727-1732 ◽  
Author(s):  
Jun Guo ◽  
Li-Shi Zhang ◽  
Yi-Mei Wang ◽  
Chang-Hui Yan ◽  
Wen-Peng Huang ◽  
...  
Keyword(s):  
Embryo Culture ◽  
Rat Embryo ◽  
Fusarium Mycotoxin ◽  
Culture Model ◽  
Rat Embryo Culture
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