scholarly journals A study of teratogenicity of hydrosalpinx fluid using a whole rat embryo culture model

2003 ◽  
Vol 18 (5) ◽  
pp. 955-958 ◽  
Author(s):  
L.Y. Chan
Keyword(s):  
Embryo Culture ◽  
Rat Embryo ◽  
Culture Model ◽  
Rat Embryo Culture

scholarly journals A study of diclofenac-induced teratogenicity during organogenesis using a whole rat embryo culture model

2001 ◽  
Vol 16 (11) ◽  
pp. 2390-2393 ◽  
Author(s):  
L.Y. Chan ◽  
P.Y. Chiu ◽  
S.S.N. Siu ◽  
T.K. Lau
Keyword(s):  
Embryo Culture ◽  
Rat Embryo ◽  
Culture Model ◽  
Rat Embryo Culture

Study of embryotoxicity of Fusarium mycotoxin butenolide using a whole rat embryo culture model

2011 ◽  
Vol 25 (8) ◽  
pp. 1727-1732 ◽  
Author(s):  
Jun Guo ◽  
Li-Shi Zhang ◽  
Yi-Mei Wang ◽  
Chang-Hui Yan ◽  
Wen-Peng Huang ◽  
...  
Keyword(s):  
Embryo Culture ◽  
Rat Embryo ◽  
Fusarium Mycotoxin ◽  
Culture Model ◽  
Rat Embryo Culture

An Interlaboratory Evaluation of Five Pairs of Teratogens and Non-teratogens in Post-implantation Rat Embryo Culture

1996 ◽  
Vol 24 (2) ◽  
pp. 201-209
Author(s):  
Aldert H. Piersma ◽  
Rudolf Bechter ◽  
Nathalie Krafft ◽  
Beat P. Schmid ◽  
Jeanne Stadler ◽  
...  
Keyword(s):  
Embryo Culture ◽  
Developmental Toxicity ◽  
Culture Method ◽  
Rat Embryo ◽  
Good Correspondence ◽  
Substituted Pyridines ◽  
Phthalic Ester ◽  
Rat Embryo Culture ◽  
Post Implantation

The usefulness of the post-implantation rat embryo culture method in screening xenobiotic compounds for developmental toxicity was validated in four laboratories with five pairs of compounds. This approach was chosen to provide information on the interlaboratory reproducibility of the results and to compare the effects of chemical analogues in embryo culture. By testing analogous compounds which are known to have different embryotoxic potencies in vivo, the discriminating power of the embryo culture method for the compound classes under study could be optimally assessed. The classes selected for testing were triazole antifungals, phthalic ester metabolites, substituted pyridines, sulphonamides and methylated xanthines. In summary, it was possible to distinguish between the compounds in three of the pairs, it was not possible to discriminate between the compounds of one pair, and it was possible to discriminate between the compounds of the other pair at two out of the four laboratories. The embryo culture results generally show a good correspondence with the embryotoxic properties of the compounds tested in vivo, although the embryo culture method appeared to be able to discriminate between only some of the pairs of chemical analogues. Some discrepancies may have arisen among the laboratories, because of methodological differences. These results suggest that the post-implantation rat embryo culture method may be a useful tool for screening xenobiotics within classes of compounds known to interfere with embryogenesis during the period of development represented in culture.

Whole rat embryo culture in serum of insulin-dependent (type-1) diabetic women

1989 ◽  
Vol 3 (3) ◽  
pp. 221-226 ◽  
Author(s):  
E.J.H. Mulder ◽  
L.J. Brader ◽  
A. Verhoef ◽  
A.H. Piersma ◽  
G.H.A. Visser ◽  
...  
Keyword(s):  
Embryo Culture ◽  
Rat Embryo ◽  
Insulin Dependent ◽  
Rat Embryo Culture ◽  
Dependent Type
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