scholarly journals Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo

2014 ◽  
Vol 23 (19) ◽  
pp. 5087-5101 ◽  
Author(s):  
Stéphane D. Vincent ◽  
Alicia Mayeuf-Louchart ◽  
Yusuke Watanabe ◽  
Joseph A. Brzezinski ◽  
Sachiko Miyagawa-Tomita ◽  
...  
Keyword(s):  
Mouse Embryo ◽  
Outflow Tract ◽  
Second Heart Field ◽  
Heart Field

scholarly journals Tbx1 regulates extracellular matrix-cell interactions in the second heart field

2019 ◽  
Vol 28 (14) ◽  
pp. 2295-2308 ◽  
Author(s):  
Daniela Alfano ◽  
Alessandra Altomonte ◽  
Claudio Cortes ◽  
Marchesa Bilio ◽  
Robert G Kelly ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cultured Cells ◽  
Time Window ◽  
Outflow Tract ◽  
Mouse Embryos ◽  
Cell Interactions ◽  
Deletion Syndrome ◽  
Cardiac Progenitors ◽  
Second Heart Field ◽  
Heart Field

Abstract Tbx1, the major candidate gene for DiGeorge or 22q11.2 deletion syndrome, is required for efficient incorporation of cardiac progenitors of the second heart field (SHF) into the heart. However, the mechanisms by which TBX1 regulates this process are still unclear. Here, we have used two independent models, mouse embryos and cultured cells, to define the role of TBX1 in establishing morphological and dynamic characteristics of SHF in the mouse. We found that loss of TBX1 impairs extracellular matrix (ECM)-integrin-focal adhesion (FA) signaling in both models. Mosaic analysis in embryos suggested that this function is non-cell autonomous, and, in cultured cells, loss of TBX1 impairs cell migration and FAs. Additionally, we found that ECM-mediated integrin signaling is disrupted upon loss of TBX1. Finally, we show that interfering with the ECM-integrin-FA axis between E8.5 and E9.5 in mouse embryos, corresponding to the time window within which TBX1 is required in the SHF, causes outflow tract dysmorphogenesis. Our results demonstrate that TBX1 is required to maintain the integrity of ECM-cell interactions in the SHF and that this interaction is critical for cardiac outflow tract development. More broadly, our data identifies a novel TBX1 downstream pathway as an important player in SHF tissue architecture and cardiac morphogenesis.

scholarly journals Hes1 Is Expressed in the Second Heart Field and Is Required for Outflow Tract Development

PLoS ONE ◽  
2009 ◽  
Vol 4 (7) ◽  
pp. e6267 ◽  
Author(s):  
Francesca Rochais ◽  
Mathieu Dandonneau ◽  
Karim Mesbah ◽  
Thérèse Jarry ◽  
Marie-Geneviève Mattei ◽  
...  
Keyword(s):  
Outflow Tract ◽  
Second Heart Field ◽  
Heart Field

scholarly journals Myocardium at the base of the aorta and pulmonary trunk is prefigured in the outflow tract of the heart and in subdomains of the second heart field

2008 ◽  
Vol 313 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Fanny Bajolle ◽  
Stéphane Zaffran ◽  
Sigolène M. Meilhac ◽  
Mathieu Dandonneau ◽  
Ted Chang ◽  
...  
Keyword(s):  
Outflow Tract ◽  
Pulmonary Trunk ◽  
Second Heart Field ◽  
Heart Field

scholarly journals Clonal analysis reveals common lineage relationships between head muscles and second heart field derivatives in the mouse embryo

Development ◽  
2010 ◽  
Vol 137 (19) ◽  
pp. 3269-3279 ◽  
Author(s):  
F. Lescroart ◽  
R. G. Kelly ◽  
J.-F. Le Garrec ◽  
J.-F. Nicolas ◽  
S. M. Meilhac ◽  
...  
Keyword(s):  
Mouse Embryo ◽  
Clonal Analysis ◽  
Second Heart Field ◽  
Heart Field ◽  
Head Muscles

scholarly journals Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development

PLoS Genetics ◽  
2014 ◽  
Vol 10 (12) ◽  
pp. e1004871 ◽  
Author(s):  
Simon A. Ramsbottom ◽  
Vipul Sharma ◽  
Hong Jun Rhee ◽  
Lorraine Eley ◽  
Helen M. Phillips ◽  
...  
Keyword(s):  
Cardiac Development ◽  
Outflow Tract ◽  
Second Heart Field ◽  
Heart Field

scholarly journals Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Kazuki Kodo ◽  
Shinsuke Shibata ◽  
Sachiko Miyagawa-Tomita ◽  
Sang-Ging Ong ◽  
Hiroshi Takahashi ◽  
...  
Keyword(s):  
Neural Crest ◽  
Outflow Tract ◽  
Cardiac Neural Crest ◽  
Second Heart Field ◽  
Heart Field

scholarly journals Second heart field cardiac progenitor cells in the early mouse embryo

2013 ◽  
Vol 1833 (4) ◽  
pp. 795-798 ◽  
Author(s):  
Alexandre Francou ◽  
Edouard Saint-Michel ◽  
Karim Mesbah ◽  
Magali Théveniau-Ruissy ◽  
M. Sameer Rana ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Mouse Embryo ◽  
Cardiac Progenitor Cells ◽  
Early Mouse Embryo ◽  
Second Heart Field ◽  
Heart Field ◽  
Early Mouse
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