scholarly journals Clonal analysis reveals common lineage relationships between head muscles and second heart field derivatives in the mouse embryo

Development ◽  
2010 ◽  
Vol 137 (19) ◽  
pp. 3269-3279 ◽  
Author(s):  
F. Lescroart ◽  
R. G. Kelly ◽  
J.-F. Le Garrec ◽  
J.-F. Nicolas ◽  
S. M. Meilhac ◽  
...  
Keyword(s):  
Mouse Embryo ◽  
Clonal Analysis ◽  
Second Heart Field ◽  
Heart Field ◽  
Head Muscles

scholarly journals An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time

2017 ◽  
Author(s):  
Florian Razy-Krajka ◽  
Basile Gravez ◽  
Nicole Kaplan ◽  
Claudia Racioppi ◽  
Wei Wang ◽  
...  
Keyword(s):  
Cell Types ◽  
Mapk Signaling ◽  
Full Potential ◽  
Pharyngeal Muscle ◽  
Feed Forward ◽  
Second Heart Field ◽  
Cell Divisions ◽  
Multipotent Progenitors ◽  
Heart Field ◽  
Head Muscles

AbstractIn embryos, multipotent progenitors divide to produce distinct progeny and express their full potential. In vertebrates, multipotent cardiopharyngeal progenitors produce second-heart-field-derived cardiomyocytes, and branchiomeric skeletal head muscles. However, the mechanisms underlying these early fate choices remain largely elusive. The tunicate Ciona emerged as an attractive model to study early cardiopharyngeal development at high resolution: through two asymmetric and oriented divisions, defined cardiopharyngeal progenitors produce distinct first and second heart precursors, and pharyngeal muscle (aka atrial siphon muscle, ASM) precursors. Here, we demonstrate that differential FGF-MAPK signaling distinguishes between heart and ASM precursors. We characterize a feed-forward circuit that promotes the successive activations of essential ASM determinants, Hand-related, Tbx1/10 and Ebf. Finally, we show that coupling FGF-MAPK restriction and cardiopharyngeal network deployment with cell divisions defines the timing of gene expression and permits the emergence of diverse cell types from multipotent progenitors.

scholarly journals Second heart field cardiac progenitor cells in the early mouse embryo

2013 ◽  
Vol 1833 (4) ◽  
pp. 795-798 ◽  
Author(s):  
Alexandre Francou ◽  
Edouard Saint-Michel ◽  
Karim Mesbah ◽  
Magali Théveniau-Ruissy ◽  
M. Sameer Rana ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Mouse Embryo ◽  
Cardiac Progenitor Cells ◽  
Early Mouse Embryo ◽  
Second Heart Field ◽  
Heart Field ◽  
Early Mouse

scholarly journals Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo

2014 ◽  
Vol 23 (19) ◽  
pp. 5087-5101 ◽  
Author(s):  
Stéphane D. Vincent ◽  
Alicia Mayeuf-Louchart ◽  
Yusuke Watanabe ◽  
Joseph A. Brzezinski ◽  
Sachiko Miyagawa-Tomita ◽  
...  
Keyword(s):  
Mouse Embryo ◽  
Outflow Tract ◽  
Second Heart Field ◽  
Heart Field

scholarly journals An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Florian Razy-Krajka ◽  
Basile Gravez ◽  
Nicole Kaplan ◽  
Claudia Racioppi ◽  
Wei Wang ◽  
...  
Keyword(s):  
Cell Types ◽  
Mapk Signaling ◽  
Full Potential ◽  
Pharyngeal Muscle ◽  
Feed Forward ◽  
Second Heart Field ◽  
Cell Divisions ◽  
Multipotent Progenitors ◽  
Heart Field ◽  
Head Muscles

In embryos, multipotent progenitors divide to produce distinct progeny and express their full potential. In vertebrates, multipotent cardiopharyngeal progenitors produce second-heart-field-derived cardiomyocytes, and branchiomeric skeletal head muscles. However, the mechanisms underlying these early fate choices remain largely elusive. The tunicate Ciona emerged as an attractive model to study early cardiopharyngeal development at high resolution: through two asymmetric and oriented divisions, defined cardiopharyngeal progenitors produce distinct first and second heart precursors, and pharyngeal muscle (aka atrial siphon muscle, ASM) precursors. Here, we demonstrate that differential FGF-MAPK signaling distinguishes between heart and ASM precursors. We characterize a feed-forward circuit that promotes the successive activations of essential ASM determinants, Hand-related, Tbx1/10 and Ebf. Finally, we show that coupling FGF-MAPK restriction and cardiopharyngeal network deployment with cell divisions defines the timing of gene expression and permits the emergence of diverse cell types from multipotent progenitors.

scholarly journals Lamb1a regulates atrial growth by limiting excessive, contractility-dependent second heart field addition during zebrafish heart development

2021 ◽  
Author(s):  
Christopher J. Derrick ◽  
Eric J. G. Pollitt ◽  
Ashley Sanchez Sevilla Uruchurtu ◽  
Farah Hussein ◽  
Emily S. Noёl
Keyword(s):  
Heart Development ◽  
Cardiac Development ◽  
Basement Membranes ◽  
Atrioventricular Canal ◽  
Cardiac Morphogenesis ◽  
Heart Morphogenesis ◽  
Second Heart Field ◽  
Heart Field ◽  
Heart Size ◽  
Zebrafish Heart

AbstractDuring early vertebrate heart development, the heart transitions from a linear tube to a complex asymmetric structure. This process includes looping of the tube and ballooning of the emerging cardiac chambers, which occur simultaneously with growth of the heart. A key driver of cardiac growth is deployment of cells from the Second Heart Field (SHF) into both poles of the heart, with cardiac morphogenesis and growth intimately linked in heart development. Laminin is a core component of extracellular matrix (ECM) basement membranes, and although mutations in specific laminin subunits are linked with a variety of cardiac abnormalities, including congenital heart disease and dilated cardiomyopathy, no role for laminin has been identified in early vertebrate heart morphogenesis. We identified dynamic, tissue-specific expression of laminin subunit genes in the developing zebrafish heart, supporting a role for laminins in heart morphogenesis.lamb1amutants exhibit cardiomegaly from 2dpf onwards, with subsequent progressive defects in cardiac morphogenesis characterised by a failure of the chambers to compact around the developing atrioventricular canal. We show that loss oflamb1aresults in excess addition of SHF cells to the atrium, revealing that Lamb1a functions to limit heart size during cardiac development by restricting SHF addition to the venous pole.lamb1amutants exhibit hallmarks of altered haemodynamics, and specifically blocking cardiac contractility inlamb1amutants rescues heart size and atrial SHF addition. Furthermore, we identify that FGF and RA signalling, two conserved pathways promoting SHF addition, are regulated by heart contractility and are dysregulated inlamb1amutants, suggesting that laminin mediates interactions between SHF deployment, heart biomechanics, and biochemical signalling during heart development. Together, this describes the first requirement for laminins in early vertebrate heart morphogenesis, reinforcing the importance of specialised ECM composition in cardiac development.

scholarly journals Expression of the BMP Receptor Alk3 in the Second Heart Field Is Essential for Development of the Dorsal Mesenchymal Protrusion and Atrioventricular Septation

2013 ◽  
Vol 112 (11) ◽  
pp. 1420-1432 ◽  
Author(s):  
Laura E. Briggs ◽  
Aimee L. Phelps ◽  
Elizabeth Brown ◽  
Jayant Kakarla ◽  
Robert H. Anderson ◽  
...  
Keyword(s):  
Second Heart Field ◽  
Bmp Receptor ◽  
Heart Field ◽  
Dorsal Mesenchymal Protrusion ◽  
Atrioventricular Septation

scholarly journals Temporally Distinct Six2 -Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease

Cell Reports ◽  
2017 ◽  
Vol 18 (4) ◽  
pp. 1019-1032 ◽  
Author(s):  
Zhengfang Zhou ◽  
Jingying Wang ◽  
Chaoshe Guo ◽  
Weiting Chang ◽  
Jian Zhuang ◽  
...  
Keyword(s):  
Heart Development ◽  
Second Heart Field ◽  
Mammalian Heart ◽  
Heart Field

scholarly journals Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndrome

2014 ◽  
Vol 24 (6) ◽  
pp. 1704-1716 ◽  
Author(s):  
Tanvi Sinha ◽  
Ding Li ◽  
Magali Théveniau-Ruissy ◽  
Mary R. Hutson ◽  
Robert G. Kelly ◽  
...  
Keyword(s):  
Digeorge Syndrome ◽  
Second Heart Field ◽  
Heart Field

scholarly journals A Boolean Model of the Cardiac Gene Regulatory Network Determining First and Second Heart Field Identity

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e46798 ◽  
Author(s):  
Franziska Herrmann ◽  
Alexander Groß ◽  
Dao Zhou ◽  
Hans A. Kestler ◽  
Michael Kühl
Keyword(s):  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Boolean Model ◽  
Second Heart Field ◽  
Cardiac Gene ◽  
Heart Field ◽  
Gene Regulatory
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