scholarly journals Neural crest cell and second heart field interactions orchestrate cardiac outflow tract development

2017 ◽  
Vol 145 ◽  
pp. S154-S155 ◽  
Author(s):  
Sophie Wiszniak ◽  
Quenten Schwarz
Keyword(s):  
Neural Crest ◽  
Neural Crest Cell ◽  
Outflow Tract ◽  
Second Heart Field ◽  
Heart Field ◽  
Crest Cell ◽  
Cardiac Outflow

scholarly journals Sonic hedgehog is required for cardiac outflow tract and neural crest cell development

2005 ◽  
Vol 283 (2) ◽  
pp. 357-372 ◽  
Author(s):  
I. Washington Smoak ◽  
N.A. Byrd ◽  
R. Abu-Issa ◽  
M.M. Goddeeris ◽  
R. Anderson ◽  
...  
Keyword(s):  
Neural Crest ◽  
Sonic Hedgehog ◽  
Neural Crest Cell ◽  
Cell Development ◽  
Outflow Tract ◽  
Crest Cell ◽  
Cardiac Outflow

scholarly journals Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion

2018 ◽  
Vol 247 (12) ◽  
pp. 1286-1296 ◽  
Author(s):  
Kimberly E. Inman ◽  
Carlo Donato Caiaffa ◽  
Kristin R. Melton ◽  
Lisa L. Sandell ◽  
Annita Achilleos ◽  
...  
Keyword(s):  
Cell Migration ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Outflow Tract ◽  
Cardiac Neural Crest ◽  
Neural Crest Cell Migration ◽  
Crest Cell

scholarly journals Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Kazuki Kodo ◽  
Shinsuke Shibata ◽  
Sachiko Miyagawa-Tomita ◽  
Sang-Ging Ong ◽  
Hiroshi Takahashi ◽  
...  
Keyword(s):  
Neural Crest ◽  
Outflow Tract ◽  
Cardiac Neural Crest ◽  
Second Heart Field ◽  
Heart Field

scholarly journals Early Embryonic Expression of AP-2α Is Critical for Cardiovascular Development

2020 ◽  
Vol 7 (3) ◽  
pp. 27
Author(s):  
Amy-Leigh Johnson ◽  
Jürgen E. Schneider ◽  
Timothy J. Mohun ◽  
Trevor Williams ◽  
Shoumo Bhattacharya ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Crest Cell ◽  
Outflow Tract ◽  
Cardiovascular Development ◽  
Surface Ectoderm ◽  
Cardiovascular Malformation ◽  
Conditional Allele ◽  
Neural Crest Cell Migration ◽  
Heart Field ◽  
Aortic Arch Arteries

Congenital cardiovascular malformation is a common birth defect incorporating abnormalities of the outflow tract and aortic arch arteries, and mice deficient in the transcription factor AP-2α (Tcfap2a) present with complex defects affecting these structures. AP-2α is expressed in the pharyngeal surface ectoderm and neural crest at mid-embryogenesis in the mouse, but the precise tissue compartment in which AP-2α is required for cardiovascular development has not been identified. In this study we describe the fully penetrant AP-2α deficient cardiovascular phenotype on a C57Bl/6J genetic background and show that this is associated with increased apoptosis in the pharyngeal ectoderm. Neural crest cell migration into the pharyngeal arches was not affected. Cre-expressing transgenic mice were used in conjunction with an AP-2α conditional allele to examine the effect of deleting AP-2α from the pharyngeal surface ectoderm and the neural crest, either individually or in combination, as well as the second heart field. This, surprisingly, was unable to fully recapitulate the global AP-2α deficient cardiovascular phenotype. The outflow tract and arch artery phenotype was, however, recapitulated through early embryonic Cre-mediated recombination. These findings indicate that AP-2α has a complex influence on cardiovascular development either being required very early in embryogenesis and/or having a redundant function in many tissue layers.

scholarly journals The FGF-BMP Signaling Axis Regulates Outflow Tract Valve Primordium Formation by Promoting Cushion Neural Crest Cell Differentiation

2010 ◽  
Vol 107 (10) ◽  
pp. 1209-1219 ◽  
Author(s):  
Jue Zhang ◽  
Julia Y.F. Chang ◽  
Yanqing Huang ◽  
Xiang Lin ◽  
Yongde Luo ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Outflow Tract ◽  
Bmp Signaling ◽  
Signaling Axis ◽  
Crest Cell
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