scholarly journals NEW MUTATIONS AND A 7-CHROMOSOME LINKAGE MAP OF SCHIZOPHYLLUM COMMUNE

Genetics ◽  
1977 ◽  
Vol 85 (3) ◽  
pp. 417-425
Author(s):  
Carl Frankel ◽  
Albert H Ellingboe
Keyword(s):  
Linkage Group ◽  
Linkage Map ◽  
Group Analysis ◽  
Schizophyllum Commune ◽  
Somatic Recombination ◽  
Linkage Relationships ◽  
New Mutations

ABSTRACT Forty-eight useful new mutations of S. commune were obtained by mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine. Their requirements and meiotic linkage relationships to each other and previously mapped areas were investigated. Several of these new mutations were incorporated into diploid strains so that the diploids contained at least one marker on every linkage group. Analysis of somatic recombination in these diploids indicated that each meiotic linkage group corresponded to an independent chromosome.

scholarly journals Half-tetrad analysis in zebrafish: mapping the ros mutation and the centromere of linkage group I.

Genetics ◽  
1995 ◽  
Vol 139 (4) ◽  
pp. 1727-1735 ◽  
Author(s):  
S L Johnson ◽  
D Africa ◽  
S Horne ◽  
J H Postlethwait
Keyword(s):  
Linkage Group ◽  
Genetic Linkage ◽  
Dna Polymorphisms ◽  
Tetrad Analysis ◽  
Significant Excess ◽  
Group I ◽  
Gynogenetic Diploid ◽  
Polymerase Chain ◽  
Linkage Relationships ◽  
New Mutations

Abstract Analysis of meiotic tetrads is routinely used to determine genetic linkage in various fungi. Here we apply tetrad analysis to the study of genetic linkage in a vertebrate. The half-tetrad genotypes of gynogenetic diploid zebrafish produced by early-pressure (EP) treatment were used to investigate the linkage relationships of two recessive pigment pattern mutations, leopard (leo) and rose (ros). The results showed that ros is tightly linked to its centromere and leo maps 31 cM from its centromere. Analysis of half-tetrads segregating for ros and leo in repulsion revealed no homozygous ros individuals among 32 homozygous leo half-tetrads--i.e., a parental ditype (PD) to nonparental ditype (NPD) ratio of 32:0. This result shows that ros is linked to leo, a mutation previously mapped to Linkage Group I. Investigation of PCR-based DNA polymorphisms on Linkage Group I confirmed the location of ros near the centromere of this linkage group. We propose an efficient, generally useful method to assign new mutations to a linkage group in zebrafish by determining which of 25 polymerase chain reaction (PCR)-based centromere markers shows a significant excess of PD to NPD in half-tetrad fish.

THE BLOB MUTANT OF TRIBOLIUM CASTANEUM

1971 ◽  
Vol 13 (4) ◽  
pp. 801-810 ◽  
Author(s):  
Peter S. Dawson
Keyword(s):  
Linkage Group ◽  
Linkage Map ◽  
Tribolium Castaneum ◽  
X Chromosome ◽  
Dosage Compensation ◽  
Incomplete Penetrance ◽  
Far Right ◽  
Flour Beetle ◽  
Variable Expressivity ◽  
Linkage Relationships

A new sex-linked mutation in the flour beetle Tribolium castaneum is described and illustrated. Blob (bb), an antennal mutant, is located near the far right end of the known linkage map of the X chromosome. It is recessive, with incomplete penetrance and variable expressivity, and fails to exhibit dosage compensation. The expression of bb is discussed in relationship to models of antennal development in this species. Apparent rediscovery of the pegleg mutation has confirmed a previous report on the linkage relationships of pearl and pegleg in linkage group II.

Linkage group analysis in Aspergillus niger

1993 ◽  
Vol 38 (6) ◽  
pp. 742-745 ◽  
Author(s):  
C. J. Bos ◽  
S. M. Slakhorst ◽  
A. J. M. Debets ◽  
K. Swart
Keyword(s):  
Aspergillus Niger ◽  
Linkage Group ◽  
Group Analysis

Two new mutations and a linkage map of Anopheles stephensi

1985 ◽  
Vol 76 (3) ◽  
pp. 205-207 ◽  
Author(s):  
S. D. Parvez ◽  
K. Akhtar ◽  
R. K. Sakal
Keyword(s):  
Linkage Map ◽  
Anopheles Stephensi ◽  
New Mutations

scholarly journals Centromere-Linkage Analysis and Consolidation of the Zebrafish Genetic Map

Genetics ◽  
1996 ◽  
Vol 142 (4) ◽  
pp. 1277-1288
Author(s):  
Stephen L Johnson ◽  
Michael A Gates ◽  
Michele Johnson ◽  
William S Talbot ◽  
Sally Horne ◽  
...  
Keyword(s):  
Linkage Group ◽  
Linkage Analysis ◽  
Genetic Analysis ◽  
Linkage Map ◽  
Rapid Method ◽  
Genetic Map ◽  
Dna Polymorphisms ◽  
Linkage Groups

Abstract The ease of isolating mutations in zebrafish will contribute to an understanding of a variety of processes common to all vertebrates. To facilitate genetic analysis of such mutations, we have identified DNA polymorphisms closely linked to each of the 25 centromeres of zebrafish, placed centromeres on the linkage map, increased the number of mapped PCR-based markers to 652, and consolidated the number of linkage groups to the number of chromosomes. This work makes possible centromere-linkage analysis, a novel, rapid method to assign mutations to a specific linkage group using half-tetrads.

scholarly journals Molecular-marker-based Genetic Analysis of Tepary Bean-derived Common Bacterial Blight Resistance in Different Developmental Stages of Common Bean

1997 ◽  
Vol 122 (3) ◽  
pp. 329-337 ◽  
Author(s):  
Geunhwa Jung ◽  
Paul W. Skroch ◽  
Dermot P. Coyne ◽  
James Nienhuis ◽  
E. Arnaud-Santana ◽  
...  
Keyword(s):  
Linkage Group ◽  
Common Bean ◽  
Linkage Map ◽  
Recombinant Inbred ◽  
Bacterial Blight ◽  
Chromosomal Region ◽  
Bacterial Disease ◽  
Common Bacterial Blight ◽  
Group 5 ◽  
Group 1

Randomly amplified polymorphic DNA (RAPD) molecular markers were used to construct a partial genetic linkage map in a recombinant inbred population derived from the common bean (Phaseolus vulgaris L.) cross PC-50 × XAN-159 for studying the genetics of bacterial disease resistance in common bean. The linkage map spanned 426 cM and included 168 RAPD markers and 2 classical markers with 11 unassigned markers. The seventy recombinant inbred lines were evaluated for resistance to two strains of common bacterial blight [Xanthomonas campestris pv. phaseoli (Smith) Dye] (Xcp). Common bacterial blight (CBB) resistance was evaluated for Xcp strain EK-11 in later-developed trifoliolate leaves and for Xcp strains, DR-7 and EK-11, in first trifoliolate leaves, seeds, and pods. One to four quantitative trait loci (QTLs) accounted for 18% to 53% of the phenotypic variation for traits. Most significant effects for CBB resistance were associated with one chromosomal region on linkage group 5 and with two regions on linkage group 1, of the partial linkage map. The chromosomal region (a 13-cM interval) in linkage group 5 was significantly associated with resistance to Xcp strains DR-7 and EK-11 in leaves, pods, and seeds. The regions in linkage group 1 were also significantly associated with resistance to both Xcp strains in more than one plant organ. In addition, a seedcoat pattern gene (C) and a flower color gene (vlae) were mapped in linkage groups 1 and 5, respectively, of the partial linkage map. The V locus was found to be linked to a QTL with a major effect on CBB resistance.

scholarly journals Tipsy, a new mutant in linkage group VII of the mouse

1961 ◽  
Vol 2 (1) ◽  
pp. 122-126 ◽  
Author(s):  
A. G. Searle
Keyword(s):  
Linkage Group ◽  
The Body ◽  
Marked Variation ◽  
Recessive Mutant ◽  
Linkage Relationships

Tipsy (symbol ti) is a fully penetrant recessive mutant in linkage group VII of the mouse. Homozygotes have a peculiar rabbit-like gait from the age of a week, followed soon after by a tendency for the fore-part of the body to sway from side to side, leading to a reeling locomotion with falling over in severely affected mice. There is marked variation in manifestation and some amelioration in older animals; both sexes are fertile.Linkage relationships in group VII are discussed and tipsy is compared with other mutants showing locomotor instability.

CAENORHABDITIS ELEGANS DEFICIENCY MAPPING

Genetics ◽  
1984 ◽  
Vol 108 (2) ◽  
pp. 331-345
Author(s):  
D Christine Sigurdson ◽  
Gail J Spanier ◽  
Robert K Herman
Keyword(s):  
Caenorhabditis Elegans ◽  
Linkage Group ◽  
Ethyl Methanesulfonate ◽  
Single Site ◽  
Crossing Over ◽  
Wild Type ◽  
Nematode Caenorhabditis Elegans ◽  
Recessive Lethal ◽  
X Ray ◽  
New Mutations

ABSTRACT Six schemes were used to identify 80 independent recessive lethal deficiencies of linkage group (LG) II following X-ray treatment of the nematode Caenorhabditis elegans. Complementation tests between the deficiencies and ethyl methanesulfonate-induced recessive visible, lethal and sterile mutations and between different deficiencies were used to characterize the extents of the deficiencies. Deficiency endpoints thus helped to order 36 sites within a region representing about half of the loci on LG II and extending over about 5 map units. New mutations occurring in this region can be assigned to particular segments of the map by complementation tests against a small number of deficiencies; this facilitates the assignment of single-site mutations to particular genes, as we illustrate. Five sperm-defective and five oocyte-defective LG II sterile mutants were identified and mapped. Certain deficiency-by-deficiency complementation tests allowed us to suggest that the phenotypes of null mutations at two loci represented by visible alleles are wild type and that null mutations at a third locus confer a visible phenotype. A segment of LG II that is about 12 map units long and largely devoid of identified loci seems to be greatly favored for crossing over.

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