scholarly journals EFFECTS ON SPERM MORPHOLOGY BY ALLELES AT THE PINK-EYED DILUTION LOCUS IN MICE

Genetics ◽  
1977 ◽  
Vol 85 (2) ◽  
pp. 303-308
Author(s):  
H Glenn Wolfe ◽  
Robert P Erickson ◽  
Linda C Schmidt
Keyword(s):  
Gene Expression ◽  
Sperm Morphology ◽  
Sperm Head ◽  
Male Sterile ◽  
Abnormal Sperm ◽  
Radiation Induced ◽  
Allelic Interaction ◽  
Head Morphology ◽  
Pink Eyed Dilution ◽  
Dark Pink

ABSTRACT Sperm head morphology was analyzed in all genotypic combinations for alleles dark pink-eye (pd) and p-sterile alleles, p  6H, pbs (p-black-eyed sterile) and p  25H. Three of these, p  6H, pbs and p  25H, were radiation induced; homozygotes and heterozygotes of these three alleles are male sterile, whereas pd/— genotypes are fertile. Sperm heads were examined by light microscopy and assigned to one of five classes: A. normal and near-normal, B. triangulate and oblate, C. spatulate, D. elongate, and E. filamentous. Males of each sterile genotype had grossly abnormal sperm and each sterile genotype differed from all other sterile genotypes and from fertile genotypes in at least one class, except p  6H/p  6H compared to pbs/pbs. Frequency distribution profiles (1) revealed a complex pattern of allelic interaction and do not support a deletion-complementation hypothesis, (2) do not show simple bimodality, which might suggest post-meiotic (haploid) gene expression, and (3) together with unpublished breeding data, show that p  25H is not a remutation of p  6H.

scholarly journals Effect of abnormal sperm head morphology on the outcome of intracytoplasmic sperm injection in humans

1997 ◽  
Vol 12 (6) ◽  
pp. 1214-1217 ◽  
Author(s):  
I. Tasdemir ◽  
M. Tasdemir ◽  
S. Tavukcuoglu ◽  
S. Kahraman ◽  
K. Biberoglu
Keyword(s):  
Intracytoplasmic Sperm Injection ◽  
Sperm Head ◽  
Abnormal Sperm ◽  
Head Morphology

scholarly journals Association of mutations in the zona pellucida binding protein 1 (ZPBP1) gene with abnormal sperm head morphology in infertile men

2011 ◽  
Vol 18 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Alexander N. Yatsenko ◽  
Derek S. O'Neil ◽  
Angshumoy Roy ◽  
Paola A. Arias-Mendoza ◽  
Ruihong Chen ◽  
...  
Keyword(s):  
Zona Pellucida ◽  
Binding Protein ◽  
Sperm Head ◽  
Infertile Men ◽  
Abnormal Sperm ◽  
Head Morphology

CFAP43-mediated intra-manchette transport is required for sperm head shaping and flagella formation

Zygote ◽  
2020 ◽  
pp. 1-7
Author(s):  
Yi Yu ◽  
Jiaxiong Wang ◽  
Liming Zhou ◽  
Haibo Li ◽  
Bo Zheng ◽  
...  
Keyword(s):  
Sperm Head ◽  
Cellular Mechanisms ◽  
Morphological Abnormalities ◽  
Sperm Flagellum ◽  
Abnormal Sperm ◽  
Sperm Head Abnormality ◽  
Head Morphology ◽  
Human And Mouse ◽  
Deficient Mice ◽  
Ectoplasmic Specialization

Summary Mutation in CFAP43 leads to severe asthenozoospermia and multiple morphological abnormalities of the sperm flagellum (MMAF) in both human and mouse. Previous studies have shown that disruption of intra-manchette transport (IMT) caused failure of flagellum assembly and sperm head shaping. In a previous study, therefore, we postulated that disruption of IMT may contribute to the failure of sperm flagellum formation and result in MMAF, however the mechanisms underlying these defects are still poorly understood. Cfap43-deficient mice were studied here to reveal the cellular mechanisms of abnormal sperm head morphology and MMAF. Depletion of Cfap43 led to abnormal spermiogenesis and caused MMAF, sperm head abnormality and oligozoospermia. Furthermore, both abnormal manchette and disorganized ectoplasmic specialization (ES) could be observed at the elongated spermatids in Cfap43-deficient mice. Therefore, our findings demonstrated that, in mice, CFAP43-mediated IMT is essential for sperm head shaping and sperm flagellum formation.

Sperm Morphology of Murid Rodents From New-Guinea and the Solomon-Islands - Phylogenetic Implications

1995 ◽  
Vol 43 (1) ◽  
pp. 17 ◽  
Author(s):  
WG Breed ◽  
KP Aplin
Keyword(s):  
Sperm Morphology ◽  
Solomon Islands ◽  
New Guinea ◽  
Sperm Head ◽  
Lateral Face ◽  
Apical Process ◽  
Transmission Electron ◽  
Phylogenetic Implications ◽  
Murid Rodents ◽  
Head Morphology

Observations on sperm morphology from most species of murid rodents from New Guinea and the Solomon Islands, based on light microscopy, are presented. Transmission electron microscopy of spermatozoa for three species in two genera are also given. All Rattus species, Melomys lanosus, M. rattoides, Lorentzimys nouhuysi and Coccymys ruemmleri have sickle-shaped sperm heads and long sperm tails. In contrast, most of the other species have sperm with a broader lateral face and three ventral processes. These processes vary somewhat in size and shape, and in two Pogonomys and one Chiruromys species there is an extension of the nucleus into the most caudal of the three processes. Species of Anisomys and Hyomys have a sperm head with a broad lateral face but with only a single apical process. Abeomelomys sevia and Solomys salebrosus each have a distinct sperm head morphology unlike that of any other Australian murid; the latter species also has an extremely short sperm tail. Taxonomic and phylogenetic inferences are drawn from these data. Some of the phylogenetic conclusions are markedly divergent from traditional views, which are based on craniodental anatomy.

scholarly journals The Morphological Effects of Methandienone on Sperm Head in Male Mice

2018 ◽  
Vol 15 (3) ◽  
pp. 643-648
Author(s):  
Marwah Y. Falih ◽  
Abbas A. Mohammed ◽  
Ghassan M. Sulaiman
Keyword(s):  
Body Weight ◽  
Adult Male ◽  
Mus Musculus ◽  
Sperm Morphology ◽  
Sperm Head ◽  
The Other ◽  
Male Mice ◽  
Genetic Damage ◽  
Head Morphology ◽  
And Control

The objective of the present study is to detect the effects of methandienone on sperm head morphology of male (Mus musculus) mice. For this purpose 55 adult male mice were used and divided into five groups: both of the control -ve and control +ve (CFA) have consisted of 5 mice, and the other three treated groups consisted of 15 mice injected orally with three doses (low, medium and high) (0.125, 0.25, 0.5) mgkg body weight methandienone, with periods (7, 21, 35) days. At the end of the treatment periods morphological abnormalities of sperm were examed. The results showed the presence of abnormal change in the form of the sperms head morphology, the effect of methandienone was dose and time dependents. The significant abnormal shapes of sperms head were observed; they were swelling head, head acrosome loss, apical hook, hammerhead, acrosome defective and other abnormalities. From these results, we can conclude Methadinone has the potential to increase the rate of deformity of head sperm morphology when increasing dose and duration of the drug, indicating that may be a genetic damage happened affects the stages of sperm formation and this needs further studies and in spite of methandienone medical uses and advantages, dose and period of treatment must be determined by a doctor.

Inherited sperm head abnormalities in the B10.M mouse strain

2010 ◽  
Vol 22 (7) ◽  
pp. 1066 ◽  
Author(s):  
Hideo Gotoh
Keyword(s):  
Functional Capacity ◽  
High Frequency ◽  
Segregation Analysis ◽  
Inbred Mouse ◽  
Sperm Head ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Abnormal Sperm ◽  
Sperm Abnormality ◽  
Head Morphology

Examination of sperm head morphology is one of the requisite tests of the functional capacity of semen in reproduction. In the present study, genetic effects on morphological sperm head abnormalities in mice were investigated. The frequency of abnormal spermatozoa was determined in 17 inbred mouse strains and it was found that strain B10.M had the highest frequency of abnormal spermatozoa (44.7%). Segregation analysis was then used to show that the abnormal sperm phenotype in B10.M mice was inherited. The results indicated that this sperm abnormality was controlled by two distinct recessive alleles. It is proposed that the high frequency of the heritable abnormal sperm phenotype in the mouse B10.M strain explains the subfertility of this strain, as evidenced by its reduced litter size.

scholarly journals Gene expression profiles among murine strains segregate with distinct differences in the progression of radiation-induced lung disease

2017 ◽  
Vol 10 (4) ◽  
pp. 425-437 ◽  
Author(s):  
Isabel L. Jackson ◽  
Fitsum Baye ◽  
Chirayu P. Goswami ◽  
Barry P. Katz ◽  
Andrew Zodda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Disease ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Radiation Induced

scholarly journals Genetic analysis of radiation-induced changes in human gene expression

Nature ◽  
2009 ◽  
Vol 459 (7246) ◽  
pp. 587-591 ◽  
Author(s):  
Denis A. Smirnov ◽  
Michael Morley ◽  
Eunice Shin ◽  
Richard S. Spielman ◽  
Vivian G. Cheung
Keyword(s):  
Gene Expression ◽  
Genetic Analysis ◽  
Human Gene ◽  
Human Gene Expression ◽  
Radiation Induced ◽  
Induced Changes
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