Cdk5 Phosphorylation of ErbB4 is Required for Tangential Migration of Cortical Interneurons

Sonja Rakić; Shigeaki Kanatani; David Hunt; Clare Faux; Anna Cariboni; Francesca Chiara; Shabana Khan; Olivia Wansbury; Beatrice Howard; Kazunori Nakajima; Margareta Nikolić; John G. Parnavelas

doi:10.1093/cercor/bht290

Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice

Neural Development ◽

10.1186/1749-8104-7-2 ◽

2012 ◽

Vol 7 (1) ◽

pp. 2 ◽

Cited By ~ 28

Author(s):

Konstantinos Zarbalis ◽

Youngshik Choe ◽

Julie A Siegenthaler ◽

Lori A Orosco ◽

Samuel J Pleasure

Keyword(s):

Tangential Migration ◽

Cortical Interneurons

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N-Cadherin Sustains Motility and Polarity of Future Cortical Interneurons during Tangential Migration

Journal of Neuroscience ◽

10.1523/jneurosci.0593-13.2013 ◽

2013 ◽

Vol 33 (46) ◽

pp. 18149-18160 ◽

Cited By ~ 39

Author(s):

C. Luccardini ◽

L. Hennekinne ◽

L. Viou ◽

M. Yanagida ◽

F. Murakami ◽

...

Keyword(s):

Tangential Migration ◽

Cortical Interneurons

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JNK signaling is required for proper tangential migration and laminar allocation of cortical interneurons

Development ◽

10.1242/dev.180646 ◽

2020 ◽

Vol 147 (2) ◽

pp. dev180646 ◽

Cited By ~ 3

Author(s):

Abigail K. Myers ◽

Jessica G. Cunningham ◽

Skye E. Smith ◽

John P. Snow ◽

Catherine A. Smoot ◽

...

Keyword(s):

Jnk Signaling ◽

Tangential Migration ◽

Cortical Interneurons

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Developmental Characterization of Zswim5 Expression in the Progenitor Domains and Tangential Migration Pathways of Cortical Interneurons in the Mouse Forebrain

10.1101/728097 ◽

2019 ◽

Author(s):

Chuan-Chie Chang ◽

Hsiao-Ying Kuo ◽

Shih-Yun Chen ◽

Kuan-Ming Lu ◽

Weng Lam Fong ◽

...

Keyword(s):

Cell Fate ◽

Expression Pattern ◽

Ganglionic Eminence ◽

Double Labeling ◽

Tangential Migration ◽

Cortical Interneurons ◽

Low Levels ◽

Migration Pathways

ABSTRACTGABAergic interneurons play an essential role in modulating cortical networks. The progenitor domains of cortical interneurons are localized in developing ventral forebrain, including the medial ganglionic eminence (MGE), caudal ganglionic eminence (CGE), preoptic area (POA) and preoptic hypothalamic border domain (POH). Here, we characterized the expression pattern of Zswim5, an MGE-enriched gene in the mouse forebrain. At E11.5 to E13.5, prominent Zswim5 expression was detected in the subventricular zone (SVZ) of MGE, CGE, POA and POH of ventral telencephalon in which progenitors of cortical interneurons resided. At E15.5 and E17.5, Zswim5 remained detectable in the SVZ of pallidal primordium (MGE). Zswim5 mRNA was markedly decreased after birth and was absent in the adult forebrain. Interestingly, Zswim5 expression pattern resembled the tangential migration pathways of cortical interneurons. Zswim5-positive cells in the MGE appeared to migrate from the MGE through the SVZ of LGE to overlying neocortex. Indeed, Zswim5 was co-localized with Nkx2.1 and Lhx6, markers of progenitos and migratory cortical interneurons. Double labeling showed that Mash1/Ascl1-positive cells did not express Zswim5. Zswim5 expressing cells showed none or at most low levels of Ki67 but co-expressed Tuj1 in the SVZ of MGE. These results suggest that Zswim5 is immediately upregulated as progenitors exiting cell cycle to become postmitotic. Given that recent studies have elucidated that the cell fate of cortical interneurons is determined shortly after postmitotic, the timing of Zswim5 expression in early postmitotic cortical interneurons suggests a potential role of Zswim5 in regulation of neurogenesis and tangential migration of cortical interneurons.

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Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and maturation

eLife ◽

10.7554/elife.56063 ◽

2021 ◽

Vol 10 ◽

Author(s):

Matthieu Genestine ◽

Daisy Ambriz ◽

Gregg W Crabtree ◽

Patrick Dummer ◽

Anna Molotkova ◽

...

Keyword(s):

Critical Role ◽

Mouse Development ◽

Paracrine Factors ◽

Embryonic Mouse ◽

Tangential Migration ◽

Mouse Cortex ◽

Neuropsychiatric Diseases ◽

Cortical Interneurons ◽

Progenitor Domain ◽

Pre Treatment

Cortical interneurons establish inhibitory microcircuits throughout the neocortex and their dysfunction has been implicated in epilepsy and neuropsychiatric diseases. Developmentally, interneurons migrate from a distal progenitor domain in order to populate the neocortex - a process that occurs at a slower rate in humans than in mice. In this study, we sought to identify factors that regulate the rate of interneuron maturation across the two species. Using embryonic mouse development as a model system, we found that the process of initiating interneuron migration is regulated by blood vessels of the medial ganglionic eminence (MGE), an interneuron progenitor domain. We identified two endothelial cell-derived paracrine factors, SPARC and SerpinE1, that enhance interneuron migration in mouse MGE explants and organotypic cultures. Moreover, pre-treatment of human stem cell-derived interneurons (hSC-interneurons) with SPARC and SerpinE1 prior to transplantation into neonatal mouse cortex enhanced their migration and morphological elaboration in the host cortex. Further, SPARC and SerpinE1-treated hSC-interneurons also exhibited more mature electrophysiological characteristics compared to controls. Overall, our studies suggest a critical role for CNS vasculature in regulating interneuron developmental maturation in both mice and humans.

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